Publications by authors named "Yu O Teselkin"
A comparative study of oxidative stress markers (ischemia-modified albumin (IMA) and the blood serum antioxidant capacity) in normal pregnancy and preeclampsia was carried out. The IMA level and blood serum antioxidant capacity increased in the following order: healthy non-pregnant women→healthy pregnant women→patients with moderate preeclampsia→patients with severe preeclampsia (p<0.001).
View Article and Find Full Text PDFThe concentrations of nitric oxide (NO) donors in the plasma of pregnant women with preeclampsia is several times higher than in healthy pregnant women. Antihypertensive drugs acting not through the NO-mediated mechanisms normalized BP in some women with preeclampsia, but did not significantly reduce the levels of NO donors in the plasma. It appears that preeclampsia is associated with insufficient NO availability for the targets, rather than low intensity of NO synthesis.
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- * Newborns with severe asphyxia showed significant changes, including a 1.6 times increase in IMA, a 2.4 times increase in antioxidant capacity, and a 1.5 times decrease in serum albumin on days 1-2.
- * By days 3-4, the indicators indicated a reduction in free-radical reactions in asphyxiated newborns, suggesting improvement with complex therapy.
Article Synopsis
- Researchers examined how well extracts from yerba mate can remove Fe(II) ions from water, finding that the aqueous extracts reduced these ions in a dose-dependent manner.
- The effectiveness is linked to polyphenolic compounds like quercetin and caffeic acid, which can bind to iron and form chelate complexes.
- The study suggests that this binding process may play a role in yerba mate’s antioxidant properties by altering the absorption spectra of the iron complexes.
Combined Effect of TLR2 Ligands on ROS Production by Mouse Peritoneal Macrophages.
Bull Exp Biol Med
November 2018
Article Synopsis
- - The study examined how TLR2 influences the production of reactive oxygen species (ROS) in mouse peritoneal macrophages using a specific chemiluminescence technique when stimulated by different ligands like zymosan and peptidoglycan.
- - It was found that the levels of ROS produced by macrophages were affected by the concentration ratios of these ligands, indicating that their effects were not independent of each other.
- - Three main interactions were identified: the combined stimulating effects of the ligands, competition between the ligands for binding, and how prior exposure to peptidoglycan primed macrophages for better response when zymosan was used.
Article Synopsis
- Dihydroquercetin is a natural flavonoid known for its antioxidant abilities, primarily through its action against free radicals and its interaction with metal ions.
- Research has demonstrated that when dihydroquercetin binds with iron (II) ions, those complexes are inactive, meaning they don't promote the breakdown of hydrogen peroxide.
- This inactivity indicates that dihydroquercetin could potentially prevent harmful reactions, like the Fenton reaction, that would otherwise generate free radicals.
We revealed a relationship between water balance and LPO in the myocardium, liver, and blood plasma during massive blood loss and irradiation with He-Ne laser. Low-intensity laser irradiation of the plasma inhibits LPO and normalizes water balance in rat tissues during massive blood loss.
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