Interleukin 6 Signalling in Heart Failure With Preserved and Reduced Ejection Fraction.

Aim: Identification of interleukin-6 (IL-6) signaling pathways in patients with chronic heart failure (CHF).

Material And Methods: The diversity of IL-6 effects is due to the presence of classical signaling and trans-signaling pathways. The study included 164 patients with CHF hospitalized for acute decompensated heart failure (ADHF), of which 129 had reduced left ventricular ejection fraction (HFrEF), and 35 had preserved ejection fraction (HFpEF).