Publications by authors named "Yu Nakano"

In the process of the unfolded protein response (UPR), the Hac1p protein is induced through a complex regulation of the HAC1 mRNA. This includes the mRNA localization on the endoplasmic reticulum (ER) membrane and stress-triggered splicing. In yeast, a specific ribosome ubiquitination process, the monoubiquitination of eS7A by the E3 ligase Not4, facilitates the translation of HAC1, a spliced form of the HAC1 mRNA.

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  • The study investigates the neutrophil-lymphocyte ratio (NLR) as a potential predictor for overall mortality in patients undergoing thoracic endovascular aortic repair (TEVAR) for degenerative thoracic aortic aneurysm (TAA).
  • Researchers analyzed data from 103 patients treated with TEVAR over nine years, finding that higher NLR, alongside age and ischemic heart disease, correlates with increased mortality risk.
  • The optimal NLR cutoff identified for predicting all-cause mortality was 3.48, indicating that elevated NLR can help identify patients at higher risk after the procedure.
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  • Electrocardiogram-gated cardiac CT imaging helps surgeons obtain precise details of a patient's heart anatomy, which is particularly beneficial for planning procedures like transaortic septal myectomy (TASM) in patients with subaortic septal hypertrophy and severe aortic stenosis.
  • In a case involving two elderly patients, surgical aortic valve replacement (SAVR) combined with TASM was performed following careful preoperative planning using cardiac CT, which provided essential measurements for the myectomy.
  • The post-surgery outcomes for both patients were positive, showing no serious complications, indicating that cardiac CT planning is a safe and effective approach for managing heart conditions related to subaortic septal hypertrophy.
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  • A study investigated the effects of simple renal cysts (SRC) on thoracic aortic aneurysm (TAA) treatment outcomes after thoracic endovascular aortic repair (TEVAR).
  • Among 103 patients, those with SRC experienced significantly less shrinkage of aneurysm sacs one year post-surgery compared to those without SRC (23.9% vs 59.6%).
  • The findings suggest that having SRC may be a predictor of poor aneurysm sac shrinkage outcomes after TEVAR, indicating a need for careful monitoring in these patients.
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An 89-year-old man with polycystic liver disease (PCLD) received uncovered self-expandable metallic stent (SEMS) placement above the papilla for malignant biliary obstruction caused by cholangiocarcinoma. He developed cholangitis ten months later due to SEMS occlusion caused by tumor ingrowth, and 2 plastic biliary stents were placed inside the SEMS across the papilla. Fever and right costal pain appeared two weeks after reintervention.

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The occurrence of a type IIIa endoleak after endovascular aortic repair is a rare, but crucial, complication leading to rupture. Treatment of a ruptured abdominal aortic aneurysm caused by a type IIIa endoleak can sometimes be challenging. We have reported the case of a 78-year-old man who had presented with a ruptured abdominal aortic aneurysm caused by a type IIIa endoleak resulting from disconnection of a contralateral limb.

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The patient was a 54-year-old gentleman with sudden chest pain. He suffered from cardiac tamponade and malperfusion of the left carotid artery and the right lower extremity due to acute type A aortic dissection. Rupture of the aortic root and a huge entry from the transverse arch to the proximal descending aorta were found.

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The subject was a man in his late 70s who was seeing a family physician for diabetes and dyslipidemia on an outpatient basis. A routine medical checkup revealed liver dysfunction, prompting an abdominal ultrasound. As a result, a large hepatic tumor was discovered, prompting a thorough examination.

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Background: Type B aortic dissection (TBAD) is treated with thoracic endovascular aortic repair (TEVAR). However, the optimal timing of the surgical intervention remains unclear. We aimed to investigate whether the timing of TEVAR impacts aortic remodeling.

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  • eIF2α phosphorylation helps regulate translation globally during stress conditions, such as the unfolded protein response (UPR), but its effects in yeast had not been clearly demonstrated before.
  • This research focused on how ribosome ubiquitination affects translation during UPR, finding that tunicamycin-induced ER stress increases the ubiquitination of certain ribosomal proteins.
  • Results showed that the monoubiquitination of ribosomal protein eS7A is essential for effective translational regulation during UPR, influencing specific mRNAs related to stress response in yeast.
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Background: The eicosapentaenoic acid to arachidonic acid ratio (EPA/AA) is attracting attention as a risk factor for peripheral artery disease (PAD). However, there have been few studies investigating the relationship between the EPA/AA ratio and atherosclerotic risk factors in patients with PAD. The purpose of the present study was to analyze atherosclerotic risk factors in patients with PAD to identify those factors associated with a low EPA/AA ratio.

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eIF2α phosphorylation-mediated translational regulation is crucial for global repression of translation by various stresses, including the unfolded protein response (UPR) in eukaryotes. Although translational control during UPR has not been extensively investigated in S. cerevisiae, Hac1-mediated production of long transcripts containing uORFs was shown to repress the translation of histidine triad nucleotide-binding 1 (HNT1) mRNA.

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Hematopoietic stem cells (HSCs) have the ability to differentiate into all types of blood cells and can be transplanted to treat blood disorders. However, it is difficult to obtain HSCs in large quantities because of the shortage of donors. Recent efforts have focused on acquiring HSCs by differentiation of pluripotent stem cells.

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We examined the natural organic matter (NOM) adsorption characteristics of super-powdered activated carbon (S-PAC) produced by pulverizing commercially available, normal PAC to a submicron particle size range. The adsorption capacities of S-PAC for NOM and polystyrene sulfonates (PSS) with molecular weights (MWs) of 1.1, 1.

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