Publications by authors named "Yu Nakaji"
Article Synopsis
- - This study aimed to assess the effectiveness of haptic feedback during telesurgery to enhance safety in robotic surgery practices.
- - Experiments involved a surgeon operating from two separate locations, and while no significant impact on task accuracy was found, the remote operations resulted in longer completion times and lower usability ratings.
- - Haptic feedback allowed surgeons to use lighter grasping forces, particularly benefiting experienced surgeons, highlighting its potential as a crucial tool for safe and effective telerobotic surgery.
Article Synopsis
- This study introduces a double-surgeon cockpit system for telesurgery, marking a significant step in developing a clinically applicable telesurgical technique.
- It involved non-specialized surgeons performing surgeries on pigs with remote assistance and evaluated the effect of internet security measures on communication during procedures.
- Results showed promising outcomes, with non-specialized surgeons performing safely and effectively, indicating the feasibility of this system as a foundation for future clinical telesurgery.
Article Synopsis
- - A study developed an AI model to predict the recurrence of colorectal cancer after surgery by analyzing digitized pathological slides from 471 patients.
- - The model showed a strong ability to classify patients' risk for recurrence with an area under the curve of 0.7245, indicating it can differentiate between better and worse survival outcomes.
- - High scores from the model were significantly linked to a worse chance of recurrence, independent of other factors, suggesting it could assist in treatment decisions like the need for adjuvant chemotherapy.
Objective: The aim of this study is to identify biomarkers that predict efficacy of preoperative therapy and survival for esophageal squamous cell carcinoma (ESCC).
Background: It is essential to improve the accuracy of preoperative molecular diagnostics to identify specific patients who will benefit from the treatment; thus, this issue should be resolved with a large-cohort, retrospective observational study.
Methods: A total of 656 patients with ESCC who received surgery after preoperative CDDP + 5-FU therapy, docetaxel + CDDP + 5-FU therapy or chemoradiotherapy (CRT) were enrolled.
Background/aim: Remnant gastric cancer (RGC) after distal gastrectomy occurs in 1-2% of patients, while the biological features of RGC are unknown.
Patients And Methods: A total of 22 consecutive patients with RGC who underwent total gastrectomy were analyzed. Their disease history included either gastric cancer (n=16) or peptic ulcer (n=6).
After publication of the original article [1] the authors noted that the following errors had occurred.
View Article and Find Full Text PDFImmunotherapy is reportedly effective in colorectal cancers (CRCs) with high microsatellite instability (MSI-H); however, the specific cell types that respond to immune checkpoint therapy are unclear. Herein, we aimed to examine the expression of programmed cell death-ligand 1 (PD-L1) and related proteins in MSI-H and microsatellite-stable (MSS) CRCs to investigate the immune microenvironment at the tumor's invasive front. The MSI status was retrospectively assessed in 499 patients undergoing surgical resection of primary CRC; of these, 48 were classified as MSI-H.
View Article and Find Full Text PDFBackground: The incidence of skeletal muscle metastasis from oesophageal cancer is very low, and the treatment strategy has not been established.
Case Report: A 77-year-old man underwent oesophagectomy following neoadjuvant chemotherapy for oesophageal squamous cell carcinoma (CT-pT3 N0 M0, CT-pStage II). Fourteen months after surgery, he became aware of a subcutaneous tumour in his left forearm.
Objectives: Programmed death 1 (PD-1) is an immunoinhibitory receptor and has been identified as a new target for immunotherapy in cancer. Here we report the expression of PD-1 ligand 1 (PD-L1) in surgically resected gastric cancer.
Materials And Methods: We examined formalin-fixed tumor samples from 144 gastric cancer patients with a primary diagnosis of gastric carcinoma.
Background/aim: The aim of this study was to clarify the treatment strategy for synchronous squamous cell carcinoma of the esophagus (ESCC) and head and neck cancer (HNC).
Patients And Methods: Treatment outcomes of 91 patients with synchronous ESCC and HNC were evaluated. Thirty-eight patients received simultaneous definitive chemoradiotherapy (CRT) and 15 patients underwent simultaneous resection.
Background: Perianal Paget's disease (pPD) is uncommon, with only about 180 cases documented in the literature. Anorectal carcinoma with pagetoid spread is even rarer.
Case Presentation: An 81-year-old woman underwent rectal cancer extirpation with a transanal approach 17 years prior.
Article Synopsis
- Chromosomal instability (CIN), marked by aneuploidy, is a key molecular type of gastric cancer, with the deubiquitinase USP44 playing a vital role in regulating proper chromosome separation.
- A study of 207 gastric cancer patients revealed that higher USP44 expression in tumors (39.6%) compared to normal tissue (14.6%) correlates strongly with DNA aneuploidy and poorer overall survival rates.
- Specifically, high USP44 expression serves as a significant poor prognostic factor for patients with aneuploid gastric cancer, influencing progression-free survival and overall survival outcomes.
Anal metastasis of colorectal cancer is very rare and is usually associated with a history of anal disease, including anal fistula, fissure, hemorrhoidectomy, and anastomotic injury. We report a case of rectal cancer with a synchronous anal metastasis consisting of adenocarcinoma of squamous cells without a history of anal disease. A 60-year-old woman had a chief complaint of melena.
View Article and Find Full Text PDFBackground: Polyarteritis nodosa (PAN) is a primary systemic necrotizing vasculitis with diffuse organ involvements, resulting in a high mortality rate due to multiple organ failure. Although the small bowel is the frequently targeted organ of PAN-associated vasculitis, rectal involvement is very rare, and only one case of rectal bleeding has been previously reported. The mortality rate of PAN with gastrointestinal (GI) perforation is reportedly much higher than that of without severe GI involvement.
View Article and Find Full Text PDFBackground: The association between sarcopenia and postoperative outcomes for patients with gastrointestinal malignancies remains controversial. This study aimed to assess the impact of sarcopenia on short- and long-term outcomes after surgery for esophagogastric junction cancer (EGJC) or upper gastric cancer (UGC).
Methods: The study reviewed 148 patients with EGJC or UGC who underwent surgical resection.
Objective: The objective of this study was to elucidate the impact of postoperative complications on long-term survival after curative resection for esophageal squamous cell carcinoma.
Background: The relation between postoperative complications and long-term survival after curative surgery for esophageal squamous cell carcinoma is controversial; thus, this issue should be resolved with a large-scale, well-designed study.
Methods: Clinicopathological features and survival of 580 consecutive patients who received curative resection for esophageal squamous cell carcinoma were investigated according to the development of postoperative pulmonary complications and anastomotic leakage.
Objective: The objectives of this retrospective study were to elucidate the clinicopathological features and recent surgical results of cervical esophageal cancer.
Summary Background Data: Cervical esophageal cancer has been reported to have a dismal prognosis. Accurate knowledge of the clinical characteristics of cervical esophageal cancer is warranted to establish appropriate therapeutic strategies.
Article Synopsis
- - A 62-year-old man was diagnosed with esophageal squamous cell carcinoma showing early invasive characteristics and lymphatic involvement after a surgical examination.
- - He underwent surgery to remove part of his esophagus and received subsequent treatments, including chemotherapy and radiation, which initially reduced his lymph node metastases.
- - However, after several years, the cancer recurred in the left adrenal gland, leading to further surgery and ultimately the patient's death due to cancer progression.
A 65-year-old man with cT3N2M0 stage III cervical esophageal cancer underwent subtotal esophagectomy and gastric tube reconstruction through the retrosternal route after neoadjuvant chemoradiotherapy. The anastomosis was located adjacent to the left side of the trachea, and a circular stapler was used for anastomosis. Postoperative anastomotic leakage occurred, and an esophagotracheal fistula between the esophagogastric anastomotic site and cartilage portion of the trachea was observed on postoperative day 44.
View Article and Find Full Text PDFPurpose: In colorectal cancer (CRC), the BRAF V600E mutation is an important biomarker for poor prognosis, while high microsatellite instability (MSI-H) indicates good prognosis. Using a commercial BRAF V600E-specific antibody, we investigated the BRAF V600E mutation according to immunohistochemistry (IHC) and the MSI status in Japanese patients with CRC.
Methods: In this retrospective study, tissue samples from 472 Japanese patients with CRC, stratified for MSI, were analyzed to determine the prognostic value of BRAF V600E, as assessed using IHC.
The importance of Notch signaling in colorectal cancer (CRC) carcinogenesis and progression has previously been presented. Increased expression of Jagged-1 (JAG1), a Notch ligand, in CRC has been revealed, but the detailed prognostic significance of JAG1 in CRC has not been determined. Protein expression of JAG1 was examined using immunohistochemistry in 158 CRC specimens.
View Article and Find Full Text PDFBackground/aim: Neuroendocrine carcinoma (NEC) of the esophagus is rare and aggressive. We herein report a case of a patient who showed NEC conversion from squamous cell carcinoma (SCC) of the esophagus in the recurrent lesion after definitive chemoradiotherapy.
Case Report: The patient was a 57-year-old Japanese male with mid-thoracic esophageal carcinoma diagnosed as SCC with invasion of the submucosal layer.
Article Synopsis
- FGFR2 genetic alterations contribute to cancer growth, and the study explored the link between FGFR2 amplification and its expression in esophagogastric junction adenocarcinoma.
- The study involved 176 patients and utilized techniques like real-time PCR and immunohistochemical staining to assess FGFR2 levels and their impact on tumor characteristics and patient survival.
- Results showed that while FGFR2 amplification was present in some cases, it was the expression of FGFR2 that significantly correlated with tumor depth and overall survival, suggesting FGFR2 as a potential new treatment target for this type of cancer.
Article Synopsis
- Cardiac tamponade is a rare but serious complication that can occur after esophagectomy for esophageal cancer, potentially resulting in sudden hemodynamic instability and death if not treated quickly.
- A case involving a 76-year-old man highlights how he experienced hypotension and altered consciousness due to bleeding in the pericardial space four days after surgery, requiring emergency drainage surgery.
- The case underscores the importance of recognizing cardiac tamponade as a possible cause of early postoperative complications and the need for prompt intervention.
Surgical treatment of stage IV non-small cell lung cancer.
Interact Cardiovasc Thorac Surg
February 2012
Most stage IV non-small-cell lung cancer (NSCLC) patients are not amenable to curative treatment. The purpose of this study was to analyse our initial experience with an aggressive surgical strategy for stage IV NSCLC, and to define which patients can benefit from this treatment. Forty-six stage IV NSCLC patients who underwent surgical resection of both primary lung cancer and metastatic sites from April 1989 to December 2010 were included in this study.
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