Publications by authors named "Yu Maejima"
Identification of oxytocin expression in human and murine microglia.
Prog Neuropsychopharmacol Biol Psychiatry
December 2022
Background: Oxytocin is a neuropeptide synthesized in the hypothalamus. In addition to its role in parturition and lactation, oxytocin mediates social behavior and pair bonding. The possibility of using oxytocin to modify behavior in neurodevelopmental disorders, such as autism spectrum disorder, is of clinical interest.
View Article and Find Full Text PDFArticle Synopsis
- Microglia respond to stress, such as lipopolysaccharide (LPS) exposure, by secreting cytokines, with the Kv1.3 channel playing a key role in this process.
- Most research has focused on long-term cytokine release, leaving a gap in understanding the rapid (within minutes) responses of microglia to stress.
- This study reveals that LPS increases Kir2.1 current quickly, as Kir2.1 moves to the cell surface, indicating its involvement in the secretion of the inflammatory cytokine IL-1β, suggesting a potential target for regulating cytokine release from microglia.
Article Synopsis
- In 2008, guidelines were established for researching autophagy, which has since gained significant interest and new technologies, necessitating regular updates to monitoring methods across various organisms.
- The new guidelines emphasize selecting appropriate techniques to evaluate autophagy while noting that no single method suits all situations; thus, a combination of methods is encouraged.
- The document highlights that key proteins involved in autophagy also impact other cellular processes, suggesting genetic studies should focus on multiple autophagy-related genes to fully understand these pathways.