Construction of a public health practice teaching quality evaluation system based on the CIPP model using the Analytic Hierarchy Process (AHP) and entropy weight method.

Objective: This study aims to establish a comprehensive evaluation system for assessing public health practice teaching quality, addressing the shortcomings of traditional evaluation methods. The framework integrates the Context, Input, Process, and Product (CIPP) model with the Analytic Hierarchy Process (AHP) and Entropy Weight Method to provide precise and balanced weightings for evaluation indicators. AHP was selected for its ability to incorporate expert judgment with consistency checks, ensuring structured decision-making, while the Entropy Weight Method enhances objectivity by assigning weights based on data variability, reducing potential biases in expert evaluations.

Meta-analysis of risk factors for recurrent gestational diabetes mellitus.

Background: To comprehensively evaluate the risk factors for recurrent gestational diabetes mellitus (GDM) in women with a history of GDM during re-pregnancy.

Methods: Articles about risk factors for recurrent GDM were searched in China National Knowledge Infrastructure, Wanfang Data, VIP Database for Chinese Technical Periodicals, PubMed, EMBASE, the Cochrane Library, and Web of Science from the date of establishment to January 2023. Meta-analysis of risk factors for recurrent GDM was performed using STATA/SE 15.

Harnessing Multi-modal Large Language Models for Measuring and Interpreting Color Differences.

The accurate measurement of perceptual color differences (CDs) between two images plays an important role in modern smartphone photography. Although traditional CD metrics provide numerical scores to quantify color variations, they often lack the ability to offer intuitive insights or explanations that reflect the factors behind these differences in a way that aligns with human perception and reasoning. Here, we present CD-Reasoning, an innovative method designed not merely to compute numerical CD scores but also to provide a detailed rationale for the observed CDs between images.

Exploring the structures and molecular mechanisms of bioactive compounds from marine foods for hyperuricemia prevention: a systematic review.

Hyperuricemia, characterized by an elevation in serum uric acid (UA) levels, stands as a significant metabolic ailment threatening human well-being. Presently, dietary adjustments have become a crucial strategy in managing serum UA levels among individuals grappling with hyperuricemia and gout. Given its unique ecosystem, the ocean hosts a plethora of organisms boasting distinct structures and active components.

Encapsulation of Fatty Acids Using Linear Dextrin from Waxy Potato Starch: Effect of Debranching Time and Degree of Unsaturation.

This study investigates the effects of the debranching time of waxy potato starch using pullulanase and recrystallization on particle morphology, debranching degree, and crystal structure. The results demonstrated that after gelatinization and debranching, the surface of the starch crystals became rough and uneven due to hydrolysis, with most particles showing a fragmented surface. The crystalline state was not significantly changed with debranching time.

Design and screening of novel molecular compounds targeting lactate dehydrogenase of Babesia microti.

Background: Human babesiosis is caused by several species within the Babesia genus, primarily Babesia microti, Babesia duncani, and Babesia divergens, all of which infect human red blood cells (RBCs). Clinically, the disease manifests with symptoms such as fever, anemia, jaundice, and hemoglobinuria, with B. microti being the most prevalent of these species.

The effect of magnetic field-induced orientation of fillers on the performance of starch composite films.

The novel starch-based film with superior gas barrier properties was developed for food packaging applications. Magnetic montmorillonite (MMT) was successfully prepared and achieved an oriented arrangement within the starch composite matrix, creating a highly oriented structure. The addition of MMT led to higher molecular chain entanglement in the starch composite system during the hot process, resulting in increased viscosity.

Lectin-like oxidized low-density lipoprotein receptor-1 reduces 5-FU sensitivity in gastric cancer cells via JAK/STAT/NOX4 axis.

5-Fluorouracil (5-FU) is the primary chemotherapeutic agent for the clinical management of advanced gastric cancer (GC). However, the emergence of drug resistance remains an inescapable challenge. In drug-resistant cancer cells, prior treatments contribute to elevated oxidative stress, resulting in higher level of reactive oxygen species (ROS) compared to treatment-naïve cancer cells.

Customized Controllable Pyrophosphate Nanosensor Based on Lanthanide Metal-Organic Frameworks for Accurate and Sensitive Detection of Nucleic Acids.

Pyrophosphate (PPi) and nucleic acid amplification play a critical role in medical diagnostics, making the development of precise nanosensors essential. Lanthanide metal-organic frameworks (Ln-MOFs) are increasingly recognized for their potential in advanced luminescent biosensing applications. However, research on customized controllable responses in Ln-MOF nanosensors is still lacking, which is critical for the molecular-level modular design.

HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients.

Background: Resistance to treatment is a critical factor contributing to poor prognosis in gastric cancer patients. HSP90 has emerged as a promising therapeutic target; however, its role in regulating tumor metabolic pathways, particularly glycolysis, remains poorly understood, which limits its clinical application.

Methods: We identified proteins that directly interact with HSP90 using immunoprecipitation (IP) followed by mass spectrometry.

Chitosan microporous foam filled 3D printed polylactic acid-pearl macroporous scaffold: Dual-scale porous structure, biological and mechanical properties.

A bone scaffold with well-designed porous structure and material composition is essential for bone regeneration as it supports various biological functions. In this study, a dual-scale porous polylactic acid-pearl/chitosan (PLA-P/CS) scaffold was developed by integrating 3D printing and conventional techniques. An interconnected macroporous PLA-P scaffold with pore sizes ranging from 680-800 μm was fabricated using FDM 3D printing.

Fluorescence-enhanced detection of sulfide ions through tuning the structure-activity relationship of gold nanoclusters.

The concentration of S is a vital environmental indicator for evaluating the quality of source water, surface water, and wastewater, and it has a significant impact on biological systems, particularly human health. Therefore, it is crucial to detect S selectively and sensitively. In this study, we developed a simple and rapid one-pot method to prepare a gold nanocluster (BSA-AuNCs) probe for fluorescence-enhanced detection of S toxemia and analyzed the morphological characteristics of BSA-AuNCs and its complex with S using various characterization techniques.

Targeting tubulin protein to combat fungal disease: Design, synthesis, and its new mechanistic insights of benzimidazole hydrazone derivatives.

As the vital the biomacromolecule in eukaryotic cells, tubulin protein is essential for preserving cell shape, facilitating cell division, and cell viability. Tubulin has been approved as promising target for anticancer, and antifungal therapy. However, there are still many gaps in tubulin-targeted fungicidal discovery.

Three-Dimensional Quantitative Structure-Activity Relationship, Antimicrobial Activity, and Molecular Docking Studies of C-14 Chiral Matrine Derivatives as Potential Antibiotics.

Antibiotic resistance is recognized as one of the top ten global public health threats, posing a significant challenge to human health. The stereochemistry of chiral molecules, alongside their specific interactions with biological targets, provides essential insights for the development of novel antibacterial agents, This study investigated the antibacterial activity of 32 previously synthesized 14-position chiral matrine derivatives. Among these derivatives, compound Q4 exhibited the strongest activity against Propionibacterium acnes, with a minimum inhibitory concentration (MIC) of 0.

Polarity Sensor Based on Multivariate Lanthanide Metal-Organic Framework for Constructing Biosensing Platform.

It is significant but challenging to develop polarity sensors that can measure multiscenario polarity in a modular, customized, sensitive, and accurate manner. In this work, we proposed a polarity sensor based on multivariate lanthanide metal-organic framework (Ln-MOF) nanoclusters through the modular programming design of ligands. This multivariate Ln-MOF combines the advantages of modularity, ease of design, high flexibility and low cost, and can be precisely customized for different polarity systems.

Strategies and Methodologies for Improving Toughness of Starch Films.

Starch films have attracted increasing attention due to their biodegradability, edibility, and potential use as animal feed from post-products. Applications of starch-based films include food packaging, coating, and medicine capsules. However, a major drawback of starch-based films is their brittleness, particularly under dry conditions, caused by starch retrogradation and the instability of plasticizers.

Multi-step optimization with operational scenarios for hull form and propulsor design for pod-driven cruise ships.

With the increasing demand for reducing CO2 emissions by the International Maritime Organization (IMO), controlling a ship's energy consumption at the design stage is crucial for proposing a 'greener' design. Some efforts have been made to consider the Energy Efficiency Design Index (EEDI) and the Energy Efficiency Operational Index (EEOI); however, the latter remains highly complex and contentious. In this study, a multistep optimization analysis method was developed to integrate EEDI and EEOI evaluations during the design stage to meet low emission requirements.

Effect of Cytoskeletal Linker Protein GAS2L1 on Oligodendrocyte and Myelin Development.

Oligodendrocytes (OLs), the myelin-forming cells of the central nervous system (CNS), develop from OL precursor cells (OPCs) through a complex process involving significant morphological changes that are critically dependent on the dynamic interactions between cytoskeletal networks. Growth arrest-specific 2-like protein 1 (GAS2L1) is a cytoskeletal linker protein that mediates the cross-talk between actin filaments and microtubules. However, its role in OL and myelin development remains unknown.

A Synergistic Effect of Remnant Cholesterol and C-Reactive Protein on Predicting the Severity of Coronary Artery Disease.

Background: Increased levels of remnant cholesterol (RC) and inflammation are linked to higher risks of atherosclerotic cardiovascular disease. Whether a combination of C-reactive protein (CRP) and RC improves the predictive ability for evaluating the severity of coronary artery lesions remains unknown.

Methods: A total of 1675 patients with coronary artery disease were stratified according to the Synergy Between Percutaneous Coronary Intervention (SYNTAX) score (SYNTAX score ≤22 versus SYNTAX score >22).

YTHDF2 influences hepatic fibrosis by regulating ferroptosis in hepatic stellate cells by mediating the expression of ACSL4 in an m A-dependent manner.

Hepatic fibrosis (HF) is an abnormal reparative response of the liver to chronic injury and is histologically reversible. In recent years, increasing interest has been given to changes in m A in liver disease. In this study, we explore the role of the m A-modified reading protein YTHDF2 in HF and its regulatory mechanism.

The Arabidopsis heterotrimeric G protein α subunit binds to and inhibits the inward rectifying potassium channel KAT1.

In animal cells, Gα subunit of the heterotrimeric G proteins can bind to both the N-terminal and C-terminal domains of G-protein-activated inwardly rectifying K channels (GIRKs) to inhibit their activities. In Arabidopsis guard cells, the Gα subunit GPA1 mediates multiple stimuli-regulated stomatal movements via inhibiting guard cell inward-rectifying K (K) current, but it remains unclear whether GPA1 directly interacts with and inhibits the activities of K channels. Here, we found that GPA1 interacted with the transmembrane domain rather than the intracellular domain of the Shaker family K channel KAT1.

Time-Resolved Levodopa Cascade Polymerization Tuned by Bimetallic MOF Fluorescent Nanozyme and Boric Acid for Butyrylcholinesterase Activity Dual-Mode Assay.

A ratiometric fluorescence-photothermal dual-mode assay method is constructed for the detection of butyrylcholinesterase (BChE) activity based on time-resolved levodopa (L-DOPA) cascade polymerization. First, a newly designed bimetallic metal-organic framework (MOF), Eu/Co-DPA (DPA: pyridine-2,6-dicarboxylic acid), is screened out as a fluorescent nanozyme with high catalytic activity and superior luminescence properties. In the presence of boric acid (BA), L-DOPA forms BA-esterified L-DOPA, which is catalyzed by Eu/Co-DPA to form the oligomers with strong blue fluorescence.

Predicting High-risk Lung Adenocarcinoma in Solid and Part-solid Nodules on Low-dose CT: A Multicenter Study.

Rationale And Objectives: High-grade patterns, visceral pleural invasion, lymphovascular invasion, spread through air spaces, and lymph node metastasis are high-risk factors and associated with poor prognosis in lung adenocarcinomas (LUADs). This study aimed to construct and validate a radiomic model and a radiographic model derived from low-dose CT (LDCT) for predicting high-risk LUADs in solid and part-solid nodules.

Materials And Methods: This study retrospectively enrolled 658 pathologically confirmed LUADs from July 2018 to December 2022 from four centers, which were divided into training set (n=411), internal validation set (n=139), and external validation set (n=108).

3D Culture System for Human Adrenal Glands That Uses a Sequential Processing Medium to Facilitate Cortical-Medullary Cell Development.

Background: The human adrenal gland is composed of the cortex and the medulla, which contain different function cells. The aim of this study was to build a 3D culture system for human adrenal glands.

Methods: Human fetal adrenal tissues were digested into a cell suspension culture and processed in three-phase 3D cultures.