Yiqi Liangxue Jiedu Prescription Inhibited the Canonical Wnt Pathway to Prevent Hepatocellular Precancerous Lesions.

Purpose: Yiqi Liangxue Jiedu prescription (YLJP), a Chinese medicine that is commonly used to prevent liver cancer and is authorized by a national patent (patent No. ZL202110889980.5) has a therapeutic effect on precancerous lesions; however, the underlying mechanism remains unclear.

mA Reader PRRC2A Promotes Colorectal Cancer Progression via CK1ε-Mediated Activation of WNT and YAP Signaling Pathways.

Colorectal cancer (CRC) is the third most common cancer type and the second highest mortality rate among cancers. However, the mechanisms underlying CRC progression remain to be fully understood. In this work, a recently identified mA-modified RNA reader protein Proline-rich Coiled-coil 2a (PRRC2A) is markedly upregulated in CRC, and intestinal epithelium-specific deletion of Prrc2a significantly suppressed tumor cell growth, stemness, and migratory capacity, while its overexpression promoted these behaviors.

Noise-induced entrainment of the circadian clock by thermoperiods in tomato: A computational approach.

The endogenous circadian rhythm (approximately 24 h) allows plants to adapt to daily light and temperature variations. Although the mechanism of photoperiod entrainment has been studied extensively, entrainment to diurnal temperature rhythms remains poorly understood. Here we investigate the stochastic entrainment of the circadian clock in the model crop tomato, subject to different thermoperiods.

Chemotaxis of rhizosphere Pseudomonas sp. induced by foliar spraying of lanthanum reduces cadmium uptake by pakchoi.

Foliar application of rare earth micronutrient of lanthanum (La) exhibits great potential in reducing cadmium (Cd) uptake in crops, the underlying mechanisms controlling the interaction between Cd toxicity-relieved crops and soil microbiota are poorly understood. In this study, LaCl with the concentrations of 10 and 30 μM was sprayed on pakchoi (Brassica chinensis L.) planting on Cd contaminated solution and soil to determine the changes of root metabolites and rhizosphere bacterial communities.

Ailanthone targets the KMT2A-MEN1 complex to suppress lung metastasis of osteosarcoma.

Background: Lung metastasis is the leading cause of death in patients with osteosarcoma (OS), and new drugs are urgently needed. Epigenetic reprogramming is a recently proposed hallmark of malignancy; therefore, targeting epigenetic enzymes might provide a novel therapeutic strategy for OS lung metastasis. We recently reported that ailanthone (AIL), a natural product isolated from the Chinese medicinal plant Ailanthus altissima, inhibits OS cell growth and induces substantial metabolic changes; however, its direct targets remain unclear.

Diagnosis, management and treatment of acquired uterine arteriovenous malformation: A case series and literature review.

The rising prevalence of cesarean sections, abortions, and other surgical interventions involving the uterus has led to an increased incidence of acquired uterine arteriovenous malformations (AVMs). These malformations primarily present as vaginal bleeding, which can significantly impair the quality of life for affected individuals and can pose life-threatening risks in severe instances. Currently, there exists considerable variability in the clinical manifestations, treatment indications, and outcomes associated with uterine AVMs, which substantially complicates clinical diagnosis and management.

Mediating Effect of Illness Perception on the Relationship Between Perceived Family Function and Sleep Quality Among Patients With Atrial Fibrillation.

Aims: To evaluate the sleep quality of patients with atrial fibrillation and its influencing factors, and explore whether illness perception mediates the relationship between family function and sleep quality.

Design: Cross-sectional survey conducted from November 2020 to November 2021.

Methods: A total of 191 participants validly completed the Pittsburgh Sleep Quality Index, the Family APGAR Index and the Brief Illness Perception Questionnaire.

Systemic tumor regression with synergy therapy: radiotherapy and CAR-T.

Pancreatic ductal adenocarcinoma (PDAC) is one of the most poorly prognostic digestive tract malignancies. CLDN18.2 CAR-T therapy has recently shown promising clinical effects in PDAC.

Randomized controlled trials of the effects of capsaicin or menthol on irritable bowel syndrome: a systematic review and meta-analysis.

Irritable bowel syndrome (IBS) is a common intestinal disease characterized by abdominal pain, abdominal distension and irregular defecation frequency, and it has had a high incidence and low cure rate in recent years. Visceral hypersensitivity (VH) is one of the main physiological indicators of IBS, and TRPV1 and TRPM8 (transient receptor potential vanilloid 1 and melastatin 8) play crucial roles in VH and are widely distributed in the intestine, significantly impacting abdominal pain in IBS patients. Under the guidance of PRISMA, four databases were systematically searched at the outset, including PubMed, Web of Science, Embase, and Cochrane Library.

Heterogeneous phenotype of a Chinese Familial WHIM syndrome with CXCR4 gain-of-function mutation.

Background: WHIM syndrome is a rare, autosomal dominant inborn error of immunity characterized by warts, hypogammaglobulinemia, infection, and myelokathexis. It is caused mainly by heterozygous mutations at the C-terminus of the C-X-C chemokine receptor type 4 (CXCR4) gene.

Methods: We described the detailed clinical, genetic, immunological and treatment characteristic of four WHIM patients from a single Chinese family.

Improved angle measurement model for folded optical paths in multi-degree-of-freedom measurement systems.

Multi-degree-of-freedom (MDOF) measurement systems are crucial in the domain of precision manufacturing, where miniaturization represents a significant developmental trend. Folded optical paths are commonly employed in the angle measurement modules of these systems as a means to reduce equipment size. However, these paths introduce angle coupling, which renders traditional angle measurement models inadequate.

Color tunable inverted pyramid micro-LEDs based on nano-patterned sapphire substrates.

Color-tunable micro-scale light-emitting diodes (Micro-LEDs) can achieve full-color display in a simple and low-cost way. In this paper, we demonstrate growth of three-dimensional (3D) inverted pyramid GaN on nano-patterned sapphire substrates (NPSS). By using the sputtered AlN nucleation layer, the uniformity of the inverted pyramid has been improved to a large extent.

Compact common-path polarization holography for measurement of the Jones matrix of polarization-sensitive materials.

A compact common-path off-axis digital holographic imaging method is proposed utilizing polarization-angular-multiplexing for Jones matrix measurement. Our method employs a common-path off-axis configuration to capture multiplexed off-axis interferograms generated by orthogonally polarized object beams and a reference beam on a monochrome CCD camera. The modulation of the fringe direction is achieved by two homemade retro-reflector mirrors, allowing for the retrieval of the Jones matrix distribution of transparent specimens through a matrix-division algorithm.

Radiomic features of dynamic contrast-enhanced MRI can predict Ki-67 status in head and neck squamous cell carcinoma.

Purpose: This study aimed to investigate the potential of radiomic features derived from dynamic contrast-enhanced MRI (DCE-MRI) in predicting Ki-67 and p16 status in head and neck squamous cell carcinoma (HNSCC).

Materials And Methods: A cohort of 124 HNSCC patients who underwent pre-surgery DCE-MRI were included and divided into training and test set (7:3), further subgroup analysis was performed for 104 cases with oral squamous cell carcinoma (OSCC). Radiomics features were extracted from DCE images.

Rehmannia glutinosa polysaccharides enhance intestinal immunity of mice through regulating the microbiota.

The Rehmannia glutinosa polysaccharides (RGP) have various benefits such as enhancing immune cell activity, decreasing oxidative stress and delaying or inhibiting tumor occurrence. Although much research has been directed at understanding the role of RGP, its influence on gut immunity is largely understudied. Here, we aimed to dissect the immune-regulating effects of RGP in the mice intestines.

Pharmacology, phytochemistry, and traditional uses of Huperzia serrata (Thunb. ex Murray) Trev.

Huperzia serrata (HS) has been a staple of traditional Chinese medicine for centuries, revered for its efficacy in treating various ailments such as pain relief, hemostasis, detoxification, dehumidification, and heat clearing. This review offers an in-depth summary of the botany, traditional utilization, pharmacology, pharmacokinetics, phytochemistry, and safety profile of HS and intends to shed light on potential future research directions and applications of this plant. Information on HS was gathered from ScienceDirect, PubMed, Springer, Sci Finder, Baidu Scholar, and Google Scholar.

Synergistic photobiocatalysis for enantioselective triple radical sorting.

Multicomponent reactions - those where three or more substrates combine into a product - have been highly useful in rapidly building chemical building blocks of increased complexity, but achieving this enzymatically has remained rare. This limitation primarily arises because an enzyme's active site is not typically set up to address multiple substrates, especially in cases involving multiple radical intermediates. Recently, chemical catalytic radical sorting has emerged as an enabling strategy for a variety of useful reactions.

Prediction of traffic accident risk based on vehicle trajectory data.

Objective: The objective of this study is to conduct precise risk prediction of traffic accidents using vehicle trajectory data.

Methods: For urban road and highway scenarios, a scheme was developed to gather vehicle kinematic data and driving operation records from an in-vehicle device. The raw trajectory samples of over 3000 vehicles were processed through cleaning, filtering, interpolation, and normalization for preprocessing.

Inactivation of CYP2D6 by Berberrubine and the Chemical Mechanism.

Berberrubine (BRB), belonging to the benzylisoquinoline alkaloid, is a main metabolite of berberine . BRB was previously proven to undergo metabolic activation mediated by P450s. In this study, the chemical interactions between BRB and CYP2D6 enzyme were investigated.

Correlation between oxygenation function and laboratory indicators in COVID-19 patients based on non-enhanced chest CT images and construction of an artificial intelligence prediction model.

Objective: By extracting early chest CT radiomic features of COVID-19 patients, we explored their correlation with laboratory indicators and oxygenation index (PaO/FiO), thereby developed an Artificial Intelligence (AI) model based on radiomic features to predict the deterioration of oxygenation function in COVID-19 patients.

Methods: This retrospective study included 384 patients with COVID-19, whose baseline information, laboratory indicators, oxygenation-related parameters, and non-enhanced chest CT images were collected. Utilizing the PaO/FiO stratification proposed by the Berlin criteria, patients were divided into 4 groups, and differences in laboratory indicators among these groups were compared.

Utilizing the apical-out enteroids model to investigate intestinal glucose transport, barrier function, oxidative stress, and inflammatory responses in broiler chickens.

Introduction: Conventional 2D intestinal epithelial cell lines have been widely used in investigating intestinal functions, yet with limitations in recapitulating the gut physiology of chickens. A recently established chicken enteroid model with apical-out nature and the presence of leukocyte components represents intestinal mucosal functions. The objectives of this study were to 1) evaluate basic gut nutrient transport and barrier functions in this model and 2) identify the model's effectiveness in studying inflammation and oxidative stress responses.

Predicting the therapeutic role and potential mechanisms of Indole-3-acetic acid in diminished ovarian reserve based on network pharmacology and molecular docking.

Background: Indole-3-acetic acid (IAA), an indole analog produced by intestinal microorganisms metabolizing tryptophan, has anti-inflammatory and antioxidant properties and thus has potential applications in ovarian protection, although the exact mechanism is unknown. The present study preliminarily investigated the pharmacological mechanism of IAA in alleviating diminished ovarian reserve (DOR) by network pharmacology and molecular docking.

Methods: Relevant target proteins of IAA were searched in SwissTargetPrediction, PharmMapper, TargetNet, BATMAN-TCM, and SuperPred databases.

Impact of varied feeding protocols on gastrointestinal function recovery in the early postoperative period following repeat cesarean section: a randomized controlled trial.

Background: With the adjustment of China's birth policy, the repeat cesarean sections raises concerns about potential gastrointestinal mechanical injuries and disturbances in gastrointestinal neurohormonal regulation, affecting the postoperative recovery of gastrointestinal function. These affect maternal nutritional status, prolong recovery, extend hospitalization, increase medical costs, and lead to neonatal care challenges.This study is to examine the effects of different postoperative feeding protocols on the restoration of gastrointestinal function in women undergoing repeat cesarean section.