Publications by authors named "Yu Kihara"
Article Synopsis
- Glomerular lipidosis is a rare kidney condition characterized by lipid buildup in the glomeruli and can be associated with macrophage activation syndrome (MAS).
- A 42-year-old patient who underwent kidney transplantation developed proteinuria and high serum triglycerides, leading to a biopsy showing CD68 foam cells and CD3 T-cells, suggesting histiocytic involvement.
- The patient was diagnosed with renal-limited MAS and treated with lipid-lowering therapy, successfully normalizing triglyceride levels, while the effectiveness of immunosuppressants remained unchanged.
Article Synopsis
- Early recovery in septic shock patients improves their overall prognosis, and the study explored whether Continuous Renal Replacement Therapy (CRRT) using polymyxin B (PMX-DHP) can stabilize their hemodynamics.
- 66 septic shock patients underwent PMX-DHP, with some receiving additional continuous hemodiafiltration (CHDF), and measurements of inflammatory cytokines (IL-6, IL-1ra, PAI-1) were taken before and after treatment.
- Results showed that PMX-DHP significantly increased Mean Arterial Pressure (MAP) and reduced cytokine levels, indicating that CRRT may be an effective strategy to improve outcomes in septic shock by modulating cytokine activity.
Kidney biopsy is commonly used to diagnose kidney transplant dysfunction after transplantation. Therefore, the development of minimally invasive and quantitative methods to evaluate kidney function in transplant recipients is necessary. Here, we used capillary electrophoresis-mass spectrometry to analyze the biofluids collected from transplant recipients with impaired (Group I, n = 31) and stable (Group S, n = 19) kidney function and from donors (Group D, n = 9).
View Article and Find Full Text PDFFemtosecond time-resolved transient absorption (TRTA) spectroscopy was carried out to investigate the ultrafast excited state dynamics of both → and ← photoisomerization of red-light-absorbing indigo derivatives. For ,'-bis(-butyloxycarbonylmethyl)indigo (BOMI), the excited state lifetime of the -form was measured to be 41 ps while that of the -form was as short as 730 fs in acetonitrile (Acn). The excited state lifetime of -,'-dimethylindigo (DMI) in Acn was also measured to be as short as 10 ps.
View Article and Find Full Text PDFRecently, steroid reduction/withdrawal regimens have been attempted to minimize the side effects of steroids in renal transplantation. However, some recipients have experienced an increase/resumption of steroid administrations and acute graft rejection (AR). Therefore, we investigated the relationship between the individual lymphocyte sensitivity to steroids and the clinical outcome after steroid reduction/withdrawal.
View Article and Find Full Text PDFBACKGROUND Everolimus (EVL) plus tacrolimus (TAC) therapy is effective and safe in renal transplantation. However, the pharmacokinetic and pharmacodynamic information for EVL combined with TAC is limited. We investigated the pharmacodynamic drug-drug interaction between EVL and TAC at their therapeutic concentration range.
View Article and Find Full Text PDFNatural chlorophylls have a D-ring reduced chlorin π-system; however, no naturally occurring photosynthetically active B-ring reduced chlorins have been reported. Here we report a B-ring reduced chlorin, 17,18-didehydro-bacteriochlorophyll (BChl) a, produced by in situ oxidation of B800 bacteriochlorophyll (BChl) a in a light-harvesting protein LH2 from a purple photosynthetic bacterium Phaeospirillum molischianum. The regioselective oxidation of the B-ring of B800 BChl a is rationalized by its molecular orientation in the protein matrix.
View Article and Find Full Text PDFWe report a case of pure red cell aplasia (PRCA) caused by parvovirus B19 (PVB19) infection, which was transmitted through a kidney allograft. The patient underwent a living-donor kidney transplant from his wife at the age of 60. Despite successful engraftment with a normal creatinine level, he developed severe anemia that required frequent blood transfusions 2 months after transplantation.
View Article and Find Full Text PDFEarly recovery from shock improves prognosis in patients with severe sepsis and septic shock. During this period, cytokine imbalances mediate the development of organ damage and mortality. In Japan, we have access to hemoperfusion using an immobilized polymyxin B fiber column for endotoxin removal (PMX-DHP) and continuous hemodiafiltration (CHDF) as artificial support for patients with septic shock, with the aim of improving hemodynamics and organ dysfunction caused by elevated inflammatory cytokines and mediators.
View Article and Find Full Text PDFArticle Synopsis
- The steroid receptor complex includes FKBP51 and FKBP52, which interact with calcineurin inhibitors (CNIs) like tacrolimus (TAC) and cyclosporine (CYA), affecting how steroid-SR complexes move within cells.
- *Research assessed how CNIs impact methylprednisolone (MPSL) sensitivity by comparing different groups of healthy subjects to renal transplant recipients.
- *Findings indicated that the presence of CNIs like TAC and CYA enhances MPSL and cortisol sensitivity, with TAC showing a stronger effect.
The in vitro response of peripheral blood mononuclear cells (PBMCs) to the suppressive effects of calcineurin inhibitors is known to correlate with the clinical efficacy of drugs used in renal transplantations. The present study was conducted to examine the differences of PBMC responses to calcineurin inhibitors between chronic renal failure (CRF) patients awaiting renal transplantation and cirrhosis patients awaiting liver transplantation. The study included 99 CRF patients awaiting renal transplantation and 27 cirrhosis patients awaiting liver transplantation.
View Article and Find Full Text PDFArticle Synopsis
- - The effectiveness of calcineurin inhibitors in kidney transplant patients is closely linked to how their drug levels are monitored, specifically looking at the area under the concentration-time curve (AUC).
- - For cyclosporine (CYA), blood levels are typically checked 2 hours after taking the drug, while for tacrolimus (TAC), levels are measured just before the next dose (trough concentration).
- - This study compared the blood concentration patterns of CYA and TAC in kidney transplant patients with similar backgrounds, revealing notable differences in their pharmacokinetics and how their levels relate to AUC.