Identifying low muscle mass and monitoring body composition changes in newly diagnosed cancer patients: Agreement between multifrequency bioelectrical impedance analysis and computed tomography.

Objectives: Low muscle mass (MM) is significant in cancer patients, and computed tomography (CT) is considered the reference standard for MM assessment. We investigated the consistency of CT and multifrequency bioelectrical impedance analysis (mBIA) in detecting body composition at baseline and during anticancer treatment and the relationship between MM and malnutrition as well as complications in lung and cervical cancer patients.

Methods: Abdominal CT and mBIA were conducted to assess body composition at baseline for all patients and repeated for patients with cervical cancer after 4 wk of chemoradiotherapy.

and inherited micro-CNV at 16p13.11 in 21 Chinese patients with defective cardiac left-right patterning.

Objective: Copy number changes at Chromosomal 16p13.11 have been implicated in a variety of human diseases including congenital cardiac abnormalities. The clinical correlation of copy number variants (CNVs) in this region with developmental abnormalities remains controversial as most of the patients inherit the duplication from an unaffected parent.

Activated human Orai1 channel in lipid biolayer may exist as a pentamer.

The human Orai1 (hOrai1) channel plays a crucial role in extracellular Ca influx and has emerged as an attractive drug target for various diseases. However, the activated structure of the hOrai1 channel assembly within a lipid bilayer remains unknown. In this study, we expressed and purified the hOrai1 channel covalently linked to two SOAR tandems (HOSS).

Mapping fine-scale carbon sequestration benefits and landscape spatial drivers of urban parks using high-resolution UAV data.

Urban parks offer dual ecological benefits by increasing carbon sinks and reducing carbon emissions and are considered an important natural strategy for cities to achieve "double carbon" goals. However, rapid, efficient, and accurate quantification of the carbon sequestration benefits of urban parks poses a significant challenge. To address this, we utilized unmanned aerial vehicle (UAV) multispectral data to construct large-area, high-resolution models of urban park carbon sequestration benefits, replacing traditional, time-consuming, and laborious large-scale field surveys.

Reamer-scraping and implant-pushing technique for transcrestal sinus floor elevation.

Transcrestal maxillary sinus floor elevation is an effective method to solve the problem of insufficient bone height in the posterior maxillary region. However, current methods, such as osteotome sinus floor elevation, cushioned grind-out technique, Smart Drill technique, etc., require specialized surgical tool boxes.

Extremely durable electrical impedance tomography-based soft and ultrathin wearable e-skin for three-dimensional tactile interfaces.

In the rapidly evolving field of human-machine interfaces (HMIs), high-resolution wearable electronic skin (e-skin) is essential for user interaction. However, traditional array-structured tactile interfaces require increased number of interconnects, while soft material-based computational methods have limited functionalities. Here, we introduce a thin and soft e-skin for tactile interfaces, offering high mapping capabilities through electrical impedance tomography (EIT).

RBPMS-AS1 sponges miR-19a-3p to restrain cervical cancer cells via enhancing PLCL1-mediated pyroptosis.

Cervical cancer (CC) poses a threat to human health. Enhancing pyroptosis can prevent the proliferation and epithelial-mesenchymal transition (EMT) of tumor cells. This study aims to reveal the candidates that modulate pyroptosis in CC.

Trends and outcomes in community-onset and hospital-onset among hospitals in the United States from 2015 to 2020.

Background: We investigated trends in (staph) bacteremia incidence stratified by methicillin susceptibility (methicillin-susceptible [MSSA] vs. methicillin-resistant [MRSA]) and onset designation (community-onset [CO] vs. hospital-onset [HO]).

Pharmacokinetics and Pharmacodynamics of a Fixed-Dose Combination of Esomeprazole and Magnesium Hydroxide Compared to the Enteric-Coated Esomeprazole.

Purpose: A fixed-dose combination (FDC) of proton pump inhibitors (PPIs) and antacid salts enables rapid acid suppression through the neutralizing effect of the antacid salt and the rapid absorption of PPIs. This study aimed to compare the pharmacokinetics (PKs) and pharmacodynamics (PDs) of a recently formulated FDC of esomeprazole and magnesium hydroxide to the enteric-coated esomeprazole in healthy subjects.

Methods: A randomized, open-label, multiple-dose, two-treatment, two-way crossover design was conducted in healthy subjects.

Water limitation drives species loss in grassland communities after nitrogen addition and warming.

Nutrient addition, particularly nitrogen, often increases plant aboveground biomass but causes species loss. Asymmetric competition for light is frequently assumed to explain the biomass-driven species loss. However, it remains unclear whether other factors such as water can also play a role.

Blood metabolites, neurocognition and psychiatric disorders: a Mendelian randomization analysis to investigate causal pathways.

Background: Neurocognitive dysfunction is observationally associated with the risk of psychiatric disorders. Blood metabolites, which are readily accessible, may become highly promising biomarkers for brain disorders. However, the causal role of blood metabolites in neurocognitive function, and the biological pathways underlying their association with psychiatric disorders remain unclear.

Dietary vitamin K intake in relation to skeletal muscle mass and strength among adults: a cross-sectional study based on NHANES.

Background: Previous studies revealed that vitamin K might help maintain muscle homeostasis, but this association has received little attention. We aimed to explore the associations of vitamin K intake with skeletal muscle mass and strength.

Methods: We included cross-sectional data from the U.

A Comprehensive Pan-Cancer Analysis Identified that TRIB3 was Associated with Immune Cell Infiltration and Poor Prognosis.

Background: Previous studies have demonstrated that TRIB3 plays a carcinogenic role in tumor progression. However, the exploration of TRIB3 at the pan-cancer level has not been reported.

Aims: This study aimed to conduct a comprehensive pan-cancer analysis of TRIB3.

Predictive value of serum HIF-1α/HIF-2α and YKL-40 levels for vascular invasion and prognosis of follicular thyroid cancer.

Objective: This study investigated the significance of serum hypoxia-inducible factor (HIF)-1α/HIF-2 α and Chitinase 3-Like protein 1 (YKL-40) levels in the assessment of vascular invasion and prognostic outcomes in patients with Follicular Thyroid Cancer (FTC).

Methods: This prospective study comprised 83 patients diagnosed with FTC, who were subsequently categorized into a recurrence group (17 cases) and a non-recurrence group (66 cases). The pathological features of tumor vascular invasion were classified.