Immunoregulatory Effects of Polysaccharide Modified Selenium Nanoparticles on H22 Tumor-Bearing Mice.

polysaccharide (CPP) and rare element selenium (Se) have been proved to exert various biological activities, and our previous study demonstrated that selenium nanoparticles modified with CPP (CPP-SeNPs) possessed significantly enhanced tumor cytotoxicity in vitro. This study aimed to investigated the inhibitory effects of CPP-SeNPs complex on H22 solid tumors via immune enhancement. In this study, the H22 tumor-bearing mice model was constructed, and the potential mechanisms of CPP-SeNPs antitumor effects were further explored by evaluating cytokines expression levels, immune cells activities and tumor cells apoptotic indicators in each group.

Lignin-enabled ultra-stretchable eutectic gels for multifunctional sensors.

Eutectic gels as important conductive polymers have promising practical applications in wearable electronic devices. However, the development of the ultra-stretchable and self-adhesive eutectic gel for multifunctional flexible sensors remains a challenge. Here, a lignin-enabled ultra-stretchable eutectic gel (LEG) integrating with excellent self-adhesion and high conductivity is prepared through polymerizable deep eutectic solvents (PDES) treated lignin followed by in-situ polymerization.

Development of an individualized dementia risk prediction model using deep learning survival analysis incorporating genetic and environmental factors.

Background: Dementia is a major public health challenge in modern society. Early detection of high-risk dementia patients and timely intervention or treatment are of significant clinical importance. Neural network survival analysis represents the most advanced technology for survival analysis to date.

Distributions of DMS and DMSP and the influences of planktonic community assemblages in the Bohai Sea and Yellow Sea.

Dimethyl sulfide (DMS) and dimethylsulfoniopropionate (DMSP) are important sulfur compounds influenced by community assemblages of plankton. The distributions of DMS, DMSP, DMSP lyase activity (DLA), DMSP-consuming bacteria (DCB), and community structures of phytoplankton and zooplankton were investigated during summer in the Bohai Sea and Yellow Sea. The variety ranges of DMS, dissolved DMSP (DMSP), and particulate DMSP (DMSP) concentrations in the surface seawater were 1.

Cluster synchronization of fractional-order two-layer networks and application in image encryption/decryption.

In this paper, a type of fractional-order two-layer network model is constructed, wherein each layer in the network exhibits distinct topology. Subsequently, the cluster synchronization problem of fractional-order two-layer networks is investigated through a two-step approach. The initial step involves the implementation of finite-time cluster synchronization in the first layer by utilizing a fractional-order finite-time convergence lemma.

Development of Reference Material of White Granulated Sugar.

Background: White granulated sugar, a significant commodity in bulk trade and widely used raw material, plays a crucial role in the food, energy, and medicine industries. A certified reference material (CRM) of white granulated sugar provides a valuable tool for monitoring and maintaining the safety and quality of white granulated sugar and other related products. The colorimetric value, conductivity ash, sucrose content, and reducing sugar content serve as essential factors that determine the quality of white granulated sugar.

A conjugated porous triazine-linked polyimide host with dual confinement of polysulfides for high-performance lithium-sulfur batteries.

In the quest for next-generation energy storage solutions, lithium-sulfur (Li-S) batteries present exceptional potential due to their high energy density and cost-effectiveness. Nevertheless, significant challenges, such as the shuttle effect of lithium polysulfides (LiPSs) and inadequate sulfur utilization, have impeded their practical application. In this study, we report the design and synthesis of a novel covalent organic polymer that integrates a triazine-linked framework with carbonyl-enriched polyimide moieties, serving as a highly effective sulfur host for Li-S batteries.

Fetal hepatocytes protect the HSPC genome via fetuin-A.

The maintenance of genomic integrity in rapidly proliferating cells is a substantial challenge during embryonic development. Although numerous cell-intrinsic mechanisms have been revealed, little is known about genome-protective effects and influences of developmental tissue microenvironments on tissue-forming cells. Here we show that fetal liver hepatocytes provide protection to haematopoietic stem and progenitor cell (HSPC) genomes.

Purification of harvested rainwater using gravity-driven ceramic membrane: A visualization study combining Micro-CT and COMSOL simulations.

Rainwater harvesting is a viable solution for providing clean water in regions where conventional water sources are scarce or contaminated. However, the harvested rainwater often contains microorganisms, suspended particles, and other impurities that must be removed before consumption. Gravity-driven ceramic membranes (GDCMs) are an efficient choice for purifying harvested rainwater due to their energy-saving properties.

Multi-scaled regulation for cholesteric organization of cellulose nanocrystals based on internal and external factors.

Cellulose nanocrystals (CNCs), as one of the most promising bio-sourced materials, have been drawing increasing attention as they offer an attractive route for the rational design and sustainable manufacturing of photonic materials owing to their cholesteric self-assembly from the suspension to solid state. Such an organization process can be readily regulated depending on either internal factors or external forces. In this review, recent advances in the control over the self-assembly process and photonic organizations of CNCs are summarized.

Preparation of nanocellulose-silk fibroin stiff hydrogel and high absorbing-low expansion xerogel via polysaccharide-protein interactions.

Inspired by the unique environmental sensitivities of polysaccharides and proteins, nanocellulose (NC) and silk fibroin (SF) nanocomposite hydrogels with tailored network structures and mechanical properties were developed by varying induction methods and assembly sequences. In the optimal process, SF was first assembled along the NC template to create a unique nanobead-like structure under thermal induction, followed by crosslinking in an acetic acid coagulation bath to form a polysaccharide-protein nanocomposite hydrogel with high mechanical strength, with elastic modulus as of 62,330 G' in Pa at only 0.25 wt% NC and 1.

Preparation Process Optimization of Glycolipids from and the Difference in Antioxidant Effects Compared with Ascorbic Acid.

Unlabelled: Background glycolipids (DOG), often left as residues after hot water extraction for polysaccharide production, are often discarded.

Methods: This study investigates the optimal extraction of DOG using response surface methodology, focusing on liquid-solid ratios, ethanol concentrations, extraction temperatures, and extraction times, while preliminarily analyzing DOG's structural properties. Additionally, the differences in antioxidant effects between DOG and ascorbic acid based on intestinal flora metabolism were further evaluated.

Analysis of Baseline Molecular Factors Associated With the Risk of Central Nervous System Progression Among Alectinib-Treated Patients With ALK-Positive NSCLC.

Introduction: Despite receiving alectinib therapy, patients with ALK-positive NSCLC remain at risk of central nervous system (CNS) progression. Our retrospective study aimed to identify baseline clinical and molecular factors associated with the risk of CNS progression in this patient subset.

Methods: We analyzed the clinical, molecular, and imaging data of 318 patients with ALK-positive advanced NSCLC who received alectinib as first-line (1L-alectinib) or second-line (2L-alectinib) therapy at baseline (1L, n = 183; 2L, n = 135) and at disease progression (1L, n = 80; 2L, n = 76).

Frontiers of myopia research in the 21st century: A bibliometric analysis of the top 100 most influential articles in the field.

Myopia is the most common refractive error worldwide, contributing not only to visual impairment but also serving as a potential risk factor for various severe ocular diseases. Its impact on patients' quality of life and health is significant and imposes substantial socioeconomic burdens. In this study, we analyzed the top 100 most cited articles related to myopia published in the Web of Science Core Collection database from January 2000 to February 2024.

Effect of whey protein hydrolysate on the structural and functional stability of surimi myofibrillar protein gels during freeze-thaw cycles.

This study investigates the effects of varying concentrations of whey protein hydrolysate (WPH) (5 %, 10 %, 15 %) on surimi myofibrillar protein gels subjected to freeze-thaw (FT) cycles. With an increase in the number of FT cycles, there was a decrease in both ionic and hydrogen bonding, resulting in reduced chewiness and elasticity. At the same time, hydrophobic interactions were strengthened, leading to disruptions in protein secondary structures.

Replication-coupled inheritance of chromatin states.

During the development of eukaryote, faithful inheritance of chromatin states is central to the maintenance of cell fate. DNA replication poses a significant challenge for chromatin state inheritance because every nucleosome in the genome is disrupted as the replication fork passes. It has been found that many factors including DNA polymerases, histone chaperones, as well as, RNA Pol II and histone modifying enzymes coordinate spatially and temporally to maintain the epigenome during this progress.

The diagnostic value and clinical relevance of high frequency ultrasound and shear wave elastography in systemic sclerosis: an observational monocentric study.

To unravel the features of skin involvement in patients with systemic sclerosis (SSc) by high frequency ultrasound (HFU) and shear wave elastography (SWE). To assess the ultrasound capabilities to distinguish SSc patients from healthy controls (HCs). We recruited a cohort of SSc patients in this cross-sectional study.

GABAergic inhibition in human hMT+ predicts visuo-spatial intelligence mediated through the frontal cortex.

The prevailing opinion emphasizes fronto-parietal network (FPN) is key in mediating general fluid intelligence (gF). Meanwhile, recent studies show that human MT complex (hMT+), located at the occipito-temporal border and involved in 3D perception processing, also plays a key role in gF. However, the underlying mechanism is not clear, yet.

Microplastics and copper impacts on feeding, oxidative stress, antioxidant enzyme activity, and dimethylated sulfur compounds production in Manila clam Ruditapes philippinarum.

Microplastics (MPs) are widespread ocean pollutants and many studies have explored their effects. However, research on MPs combined impact with copper (Cu) on dimethylated sulfur compound production is limited. Dimethyl sulfide (DMS) is an important biogenic sulfur compound related to global temperatures.

A Trustable Data-Driven Optimal Power Flow Computational Method With Robust Generalization Ability.

Data-driven optimal power flow (OPF) approach has been a research focus in recent years. However, the current data-driven OPF approaches face the following difficulties: 1) the data-driven solutions may have large deviations and are not trustable, facing out-of-distribution (OOD) samples and 2) it is hard to judge whether the solutions of the data-driven approach can be trusted. To handle these problems, this article first improves the generalization ability of the data-driven OPF method by embedding the inherent pattern of the OPF solution into the data-driven learning process.