Publications by authors named "Yu Jiewei"
Background: Diabetes retinopathy (DR) is a chronic, progressive, and potentially harmful retinal disease associated with persistent hyperglycemia. Autophagy is a lysosome-dependent degradation pathway that widely exists in eukaryotic cells, which has recently been demonstrated to participate in the DR development. Stachydrine (STA) is a water-soluble alkaloid extracted from .
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- The study investigates the role of circ-UBAP2 in diabetic retinopathy (DR), which is found to be upregulated in patients and high glucose-treated retinal cells.
- Researchers measured oxidative stress markers and cell viability, discovering that downregulating circ-UBAP2 alleviated oxidative stress and dysfunction in human retinal microvascular endothelial cells (hRMECs).
- The mechanism involves circ-UBAP2 sponging miR-589-5p, leading to the overexpression of its target gene EGR1, which contributes to gHG-induced oxidative stress and could serve as a therapeutic target for DR.