Combination of radiotherapy and PD-L1 blockade induces abscopal responses in EGFR-mutated lung cancer through activating CD8 T cells.

Patients with EGFR-mutated non-small cell lung cancer (NSCLC) respond poorly to immune checkpoint inhibitors (ICIs). It has been reported that the number of CD8T cells is reduced in EGFR-mutated NSCLC. However, the extent of heterogeneity and effector function of distinct populations of CD8T cells has not been investigated intensively.

Who benefit from adjuvant chemotherapy in stage I lung adenocarcinoma? A multi-dimensional model for candidate selection.

Background: Despite promising overall survival of stage I lung adenocarcinoma (LUAD) patients, 10-25 % of them still went through recurrence after surgery. [1] While it is still disputable whether adjuvant chemotherapy is necessary for stage I patients. [2] IASLC grading system for non-mucinous LUAD shows that minor high-grade patterns are significant indicator of poor prognosis.

Prognostic Value of Inflammatory Biomarkers in Patients With Stage I Lung Adenocarcinoma Treated With Surgical Dissection.

Objective: Inflammation plays a crucial role in tumorigenesis and progression. Our purpose was to investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index (SIRI) and systemic immune-inflammation index (SII), and develop a nomogram to predict the cancer-specific survival (CSS) and disease-free survival (DFS) of stage I lung adenocarcinoma patients.

Methods: 1431 patients undergoing surgical resection with pathologically confirmed stage I lung adenocarcinoma were reviewed.

Long-term music adjuvant therapy enhances the efficacy of sub-dose antiepileptic drugs in temporal lobe epilepsy.

Aims: Noninvasive music adjuvant therapy shows great potential in improving seizure control when combined with routine antiepileptic drugs. However, the diversity of previous music protocols has resulted in disparate outcomes. The optimized protocol and features for music adjuvant therapy are still not fully understood which limits its feasibility.

Radiotherapy for non-small cell lung cancer in the immunotherapy era: the opportunity and challenge-a narrative review.

Immunotherapy has radically changed the clinical management of patients with cancer in recent years. Immune checkpoint inhibitors (ICIs) reversing the immunosuppressive effects of the tumor microenvironment are one type of immunotherapy, several of which are approved by the US Food and Drug Administration (FDA) as first-line treatments for patients with non-small cell lung cancer (NSCLC). However, response rates to ICIs are around 19-47% among patients with advanced NSCLC.

Progression signature underlies clonal evolution and dissemination of multiple myeloma.

Clonal evolution drives tumor progression, dissemination, and relapse in multiple myeloma (MM), with most patients dying of relapsed disease. This multistage process requires tumor cells to enter the circulation, extravasate, and colonize distant bone marrow (BM) sites. Here, we developed a fluorescent or DNA-barcode clone-tracking system on MM PrEDiCT (progression through evolution and dissemination of clonal tumor cells) xenograft mouse model to study clonal behavior within the BM microenvironment.

Genome instability in multiple myeloma.

Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by clonal proliferation of plasma cells and a heterogenous genomic landscape. Copy number and structural changes due to chromosomal instability (CIN) are common features of MM. In this review, we describe how primary and secondary genetic events caused by CIN can contribute to increased instability across the genome of malignant plasma cells; with a focus on specific driver genomic events, and how they interfere with cell-cycle checkpoints, to prompt accelerated proliferation.

Nonautonomous matter waves in a spin-1 Bose-Einstein condensate.

To investigate nonautonomous matter waves with time-dependent modulation in a one-dimensional trapped spin-1 Bose-Einstein condensate, we hereby work on the generalized three-coupled Gross-Pitaevskii equations by means of the Hirota bilinear method. By modulating the external trap potential, atom gain or loss, and coupling coefficients, we can obtain several nonautonomous matter-wave solitons and rogue waves including "bright" and "dark" shapes and arrive at the following conclusions: (i) the external trap potential and atom gain or loss can influence the propagation of matter-wave solitons and the duration and frequency of bound solitonic interaction, but they have little effect on the head-on solitonic interaction; (ii) through numerical simulation, stable evolution of the matter-wave solitons is realized with a perturbation of 5% initial random noise, and the spin-exchange interaction of atoms can be affected by the time-dependent modulation; (iii) under the influence of a periodically modulated trap potential and periodic atom gain or loss, rogue waves can emerge in the superposition of localized character and periodic oscillating properties.

Isolation of a methyl parathion-degrading strain Stenotrophomonas sp. SMSP-1 and cloning of the ophc2 gene.

A rod-shaped, gram-negative bacterium Stenotrophomonas sp. SMSP-1 was isolated from the sludge of a wastewater treating system of a pesticide manufacturer. Strain SMSP-1 could hydrolyze methyl parathion to p-nitrophenol (PNP) and dimethyl phosphorothioate but could not degrade PNP further.

[Effects of (-)-epigallocatechin-3-gallate on interleukin-1beta expression in mouse wound healing].

(-)-Epigallocatechin-3-gallate (EGCG), a main constituent of green tea polyphenols, plays important roles in antioxidative, anti-senescence, anti-tumor, anti-inflammation and bacterail action. In this study, effects of EGCG on the expression of IL-1beta gene and the IL-1beta level at wound sites during cutaneous wound healing were investigated with histological stain, ELISA and RT-PCR technique. The results show that EGCG (50 mg/L) inhibited the expression of IL-1beta gene and reduced the IL-beta level at wound sites at 72 h after cutaneous wound, but not change the expression of IL-1beta gene and the IL-1beta level at early stage (< or =24 h).

[Isolation, identification and characteristics of a phoxim-degrading bacterium XSP-1].

A bacteria strain XSP-1 capable of utilizing phoxim as sole carbon source was isolated from sludge collected from a pesticide manufacturer. It was preliminarily identified as Delftia sp. according to its physiological-biochemical analysis and the similarity analysis of its 16S rRNA gene sequence (GenBank Accession No.

[Bioremediation of fenpropathrin-contaminated soil by Sphingomonas sp.JQL4-5].

JQL4-5 (Sphingomonas sp.), a fenpropathrin-degrading strain isolated from soils exposed to repeated pesticides contamination, was used in this work to study factors affecting its degrading capacity of fenpropathrin in soil microcosms. In sterilized soil, the degradation rates of fenpropathrin by JQL4-5 were faster than those in unsterilized soil.

Isolation and characterization of a carbofuran-degrading strain Novosphingobium sp. FND-3.

A gram-negative Novosphingobium sp. strain FND-3 capable of degrading carbofuran was isolated and characterized. The carbofuran-degrading ability of strain FND-3 was investigated under various culture conditions.