Synthesis of Dual Target CPT-Ala-Nor Conjugates and Their Biological Activity Evaluation.

Background: Target therapy has been one of the important strategies in new drug discovery and the resulting drug resistance has also been a serious problem for concern. At the same time, there are several cancer genes or pathways operating within a given cancer. Given these two things, the combination therapy will be needed for optimal therapeutic effect.

The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation .

A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress cancer cell growth . These conjugated pro-drug constructs possess therapeutic potential as novel bi-functional conjugate platforms for cancer treatment.

[Effect of environmental and biotic factors on net ecosystem CO exchange over a coastal wetland in the Yellow River Delta].

Using the eddy covariance technique, we measured the net ecosystem CO exchange (NEE) and its environmental and biotic factors over a coastal wetland in the Yellow River Delta to investigate the diurnal and seasonal variation in NEE and quantify the effect of environmental and biotic factors on NEE. The results showed that the diurnal change of NEE showed a distinct U-shaped curve during the growing season, but not with substantial variation in its amplitude during the non-growing season. During the growing season, the wetland acted as a significant net sink for CO, while it became carbon source during the non-growing season.

Human macrophage metalloelastase correlates with angiogenesis and prognosis of gastric carcinoma.

Background And Aims: The function of human macrophage metalloelastase (HME) also known as matrix metalloproteinase 12, in tumorigenesis is contradictory. The current study was designed to investigate the association of HME expression with angiogenesis and prognosis of gastric carcinomas.

Methods: In situ hybridization and immunohistochemistry were used to detect HME in human gastric carcinomas, chronic gastritis with atypical hyperplasia, and normal gastric epithelium mucosa.