Publications by authors named "Yu Inoue"

Background: The impact of interventions based on a biopsychosocial (BPS) model, including components related to sleep and nutrition, on pain after total knee arthroplasty (TKA) remains unclear. The purpose of this study was to develop patient education (PE) based on the BPS model and to clarify its effects on pain after TKA.

Methods: Participants were 121 patients who had undergone unilateral TKA for knee osteoarthritis.

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Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma (PCAE-CTL) is a rare subtype of cutaneous T-cell lymphoma with a poor prognosis. We herein report a case of PCAE-CTL accompanied by anti-Ma2 antibody-positive paraneoplastic encephalitis. A 33-year-old woman with erythema and disturbance of consciousness was diagnosed with PCAE-CTL by a skin biopsy.

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: This study aimed to investigate the differences in spatiotemporal gait parameters in patients who underwent surgery for hip fractures when using walking poles and T-canes. : This cross-sectional study enrolled eight patients who underwent surgery for a unilateral hip fracture (mean age of 79.0 ± 7.

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Objective: This study aimed to derive a clinical prediction rule (CPR) that can predict changes in health-related quality of life at 5 months for patients with knee osteoarthritis (KOA) undergoing conservative treatment.

Methods: Patients with KOA receiving physical therapy and exercise therapy at an outpatient clinic were included in this study. The basic characteristics, medical information, and motor function test results were recorded at baseline.

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AUTS2 syndrome is characterized by intellectual disability and microcephaly, and is often associated with autism spectrum disorder, but the underlying mechanisms, particularly concerning microcephaly, remain incompletely understood. Here, we analyze mice mutated for the transcriptional regulator AUTS2, which recapitulate microcephaly. Their brains exhibit reduced division of intermediate progenitor cells (IPCs), leading to fewer neurons and decreased thickness in the upper-layer cortex.

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The sympathetic nervous system is crucial for responding to environmental changes. This regulation is coordinated by the spinal sympathetic preganglionic neurons (SPNs), innervating both postganglionic neurons and the adrenal gland. Despite decades of research supporting the concept of selective control within this system, the neural circuit organization responsible for the output specificity remains poorly understood.

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Article Synopsis
  • The study aimed to validate clinical prediction rules for identifying locomotive syndrome in older adults living in the community, which can help in early detection.
  • Researchers evaluated physical function tests and demographic factors from 280 participants, mainly women with an average age of 74.8 years, to assess the severity of locomotive syndrome.
  • The results showed that the first two predictive models had moderate accuracy in discriminating the stages of locomotive syndrome, indicating their reliability for use in this population.
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  • - Increased lactate levels from glycolysis are being studied as potential markers for metabolic changes in neurons, linked to a drop in brain pH, which has been associated with various neuropsychiatric disorders like schizophrenia and autism.
  • - Research shows that these pH and lactate changes are common across different animal models, including those for depression, epilepsy, and Alzheimer's disease, though findings vary, particularly within the autism spectrum.
  • - A large-scale analysis indicated that higher lactate levels correlate with worse working memory performance, suggesting that altered brain chemistry might reflect underlying conditions across multiple disorders.
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  • Astrocytes play a vital role in clearing glutamate from synapses, but the specific functioning of their transporters around synapses is not fully understood.
  • Research shows that the Down syndrome cell adhesion molecule (DSCAM) in Purkinje cells is crucial for proper synapse formation and function in the cerebellum, with defects observed in Dscam-mutant mice.
  • This study highlights the importance of the interaction between synaptic proteins and astrocytic transporters, indicating that DSCAM is essential for motor learning, although it doesn’t affect gross motor coordination.
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  • Azacitidine (AZA) is a standard treatment for patients with myelodysplastic syndrome (MDS) who cannot undergo transplantation, but early treatment often faces interruptions due to hematological toxicities.
  • A multicenter retrospective study involving 212 MDS patients examined factors affecting survival during the early phase of AZA therapy, specifically focusing on severe cytopenia and its impact on patient outcomes.
  • The study identified that severe thrombocytopenia and very poor risk cytogenetics are key independent prognostic factors, leading to the creation of the Kyoto Conditional Survival Scoring System to better assess patient risks during AZA treatment.
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Objective: This preliminary study aimed to explore the reference values of spatiotemporal and kinematic parameters in the lower extremities and trunk during gait for the healthy older adults.

Methods: Walking speed, stride length and time, cadence, walk ratio, and step width were calculated as spatiotemporal parameters of gait. Forward tilting of the trunk (FTT), hip flexion and extension, knee flexion and extension, and their laterality were measured as peak angles during one-gait cycle.

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Clustered protocadherin (Pcdh) functions as a cell recognition molecule through the homophilic interaction in the central nervous system. However, its interactions have not yet been visualized in neurons. We previously reported PcdhγB2-Förster resonance energy transfer (FRET) probes to be applicable only to cell lines.

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The epidermis is an essential organ for life by retaining water and as a protective barrier. The epidermis is maintained through metabolism, in which basal cells produced from epidermal stem cells differentiate into spinous cells, granular cells and corneocytes, and are finally shed from the epidermal surface. This is epidermal turnover, and with aging, there is a decline in epidermis function.

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The prognostic impact of patient-related factors, including age, nutritional parameters, and inflammation status, in higher-risk myelodysplastic syndromes (HR-MDS) has been largely unexplored. This multicenter retrospective study aimed to establish a real-world practice-based prognostic model for HR-MDS by considering both disease- and patient-related parameters in 233 patients treated with AZA monotherapy at seven institutions. We found that anemia, presence of circulating blasts in peripheral blood, low absolute lymphocyte count, low total cholesterol (T-cho) and albumin serum levels, complex karyotype, and del(7q) or  - 7 were poor prognostic factors.

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The use of chimeric antigen receptor T-cell (CAR-T) therapy for hematologic malignancies is rapidly increasing, and appropriately managing adverse events (AEs) is crucial. Cytokine release syndrome (CRS) is a common AE of CAR-T therapy, characterized by systemic symptoms such as fever and respire-circulatory failure. We present two cases with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) accompanied by a rare complication of cervical local CRS as an acute inflammatory reaction at a specific site after CAR-T infusion.

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Background: Biopsychosocial factors are involved in the occurrence of chronic post-surgical pain (CPSP) after total knee arthroplasty (TKA). The purpose of this study was to develop a clinical prediction rule (CPR) that considers biopsychosocial factors to predict which patients are more likely to develop CPSP after TKA.

Methods: CPSP after TKA was dichotomized into CPSP and non-CPSP groups using the Likert scale and Minimal clinically important difference, and binomial logistic regression analysis was performed.

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Organoids are regarded as physiologically relevant cell models and useful for compound screening for drug development; however, their applications are currently limited because of the high cost of their culture. We previously succeeded in reducing the cost of human intestinal organoid culture using conditioned medium (CM) of L cells co-expressing Wnt3a, R-spondin1, and Noggin. Here, we further reduced the cost by replacing recombinant hepatocyte growth factor with CM.

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This study examined the relationship between abnormal gait pattern and physical activity level one year later in patients with knee osteoarthritis (KOA) and determined the clinical utility of the abnormal gait pattern examination. Initially, the patients' abnormal gait pattern was assessed using seven items, based on the scoring system reported in a previous study. The grading was based on a three-criteria system with 0: no abnormality, 1: moderately abnormal, and 2: severely abnormal.

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DnaJ homolog, subfamily B, member 4, a member of the heat shock protein 40 chaperones encoded by DNAJB4, is highly expressed in myofibers. We identified a heterozygous c.270 T > A (p.

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Type 1 ryanodine receptor (RYR1) is a Ca2+ release channel in the sarcoplasmic reticulum (SR) of the skeletal muscle and plays a critical role in excitation-contraction coupling. Mutations in RYR1 cause severe muscle diseases, such as malignant hyperthermia, a disorder of Ca2+-induced Ca2+ release (CICR) through RYR1 from the SR. We recently reported that volatile anesthetics induce malignant hyperthermia (MH)-like episodes through enhanced CICR in heterozygous R2509C-RYR1 mice.

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  • Stress can significantly affect skin conditions and aging, particularly in females, with genetic factors playing a role in individual stress responses.
  • The study analyzed 1,200 Japanese females, linking stress levels to their skin conditions and identifying specific genetic markers (SNPs) related to stress susceptibility.
  • A key finding was the SNP rs74548608, which may influence how stress is perceived, and is associated with a gene involved in cellular signaling.
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Mitochondria have their own DNA (mtDNA). Genetic variants are likely to accumulate in mtDNA, and its base substitution rate is known to be very fast, 10-20 times faster than that of nuclear DNA. For this reason, mtSNPs (mitochondrial genome single nucleotide polymorphisms) are frequently detected in mtDNA.

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  • Solar lentigo (SL) is a type of skin discoloration caused by sun exposure, characterized by excess melanin in the skin's outer layer and changes in the dermis.
  • The study found that SL lesions have reduced levels of type IV collagen, crucial for the basement membrane's structure, which affects the interaction between skin cells.
  • The research identified that while dermal stem cells can boost collagen production through exosomes, this process is impaired in SL conditions, resulting in ongoing melanin build-up in the dermis.
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The human vesicular monoamine transporter 1 () harbors unique substitutions (Asn136Thr/Ile) that affect monoamine uptake into synaptic vesicles. These substitutions are absent in all known mammals, suggesting their contributions to distinct aspects of human behavior modulated by monoaminergic transmissions, such as emotion and cognition. To directly test the impact of these human-specific mutations, we introduced the humanized residues into mouse via CRISPR/Cas9-mediated genome editing and examined changes at the behavioral, neurophysiological, and molecular levels.

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