Mesenchymal Stem Cells Transplantation in Intracerebral Hemorrhage: Application and Challenges.

Intracerebral hemorrhage (ICH) is one of the leading causes of death and long-term disability worldwide. Mesenchymal stem cell (MSC) therapies have demonstrated improved outcomes for treating ICH-induced neuronal defects, and the neural network reconstruction and neurological function recovery were enhanced in rodent ICH models through the mechanisms of neurogenesis, angiogenesis, anti-inflammation, and anti-apoptosis. However, many key issues associated with the survival, differentiation, and safety of grafted MSCs after ICH remain to be resolved, which hinder the clinical translation of MSC therapy.

Post-radiation circulating tumor DNA as a prognostic factor in locally advanced esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) is a highly malignant and deadly tumor. Radiation therapy is one of the primary treatments for locally advanced ESCC. However, the biomarkers for prognosis of definitive radiation remain undefined.

Hsp40 Protein LeDnaJ07 Enhances the Thermotolerance of and Regulates IAA Biosynthesis by Interacting LetrpE.

Our previous study found that RNAi decreased resistance to heat stress and infection. In this study, the structure and function of the gene was analyzed by gene cloning and overexpression in stress-sensitive strain YS55 via the -mediated transformation method. Transformants were confirmed by qRT-PCR, fluorescence observation and Southern blotting.

Ductopenia and cirrhosis in a 32-year-old woman with progressive familial intrahepatic cholestasis type 3: A case report and review of the literature.

Progressive familial intrahepatic cholestasis type 3 is caused by a mutation in the ATP-binding cassette, subfamily B, member 4 () gene encoding multidrug resistance protein 3. A 32-year-old woman with a history of acute hepatitis at age 9 years was found to have jaundice during pregnancy in 2008, and was diagnosed as having intrahepatic cholestasis of pregnancy. In 2009, she underwent cholecystectomy for gallstones and chronic cholecystitis.

Proteome and Transcriptome Reveal Involvement of Heat Shock Proteins and Indoleacetic Acid Metabolism Process in Lentinula Edodes Thermotolerance.

Background/aims: Heat stress could cause huge losses for Lentinula edodes in China and other Asian cultivation areas. Yet our understanding of mechanism how to defend to heat stress is incomplete.

Methods: Using heat-tolerant and heat-sensitive strains of L.

Longitudinal study on infants' temperament and physical development in Beijing, China.

The objective of this longitudinal study is to explore the relationship between temperament and physical development among infants in Beijing, China. A total of 1117 term, normal and singleton infants were followed regularly for 12 months. Body weight and horizontal length were measured at 42 days and monthly from the third to twelfth month of their lives.

Relationship between occupational stress and coping strategy among operating theatre nurses in China: a questionnaire survey.

Aim: To explore the relationship between occupational stress and coping strategies among operating theatre nurses in China.

Background: Studies on occupational stress and burnout in nurses are common, but there is a dearth of research on the coping strategies of operating theatre nurses.

Methods: A cross-sectional study was conducted in a typical operating theatre in China.

A longitudinal study on the catch-up growth of preterm and term infants of low, appropriate, and high birth weight.

The purpose of present study was to explore the trajectories of growth of preterm and term infants of low, high, and appropriate birth weight. A total of 2465 infants were recruited from 2005 to 2007. Infants' length and weight were measured at 12 points: birth, 42 days, and monthly from 3 to 12 months.

[Centrographic analysis in Shanghai adults with normal occlusion].

Purpose: To obtain the reference value of centrographic analysis of Shanghai adults with normal occlusion.

Methods: Seventy five subjects of Han nationality at permanent dentition with normal occlusion were selected from Shanghai region (34 males, 41 females, age rang:18-21 years). Centrographic analysis was conducted on the basis of the lateral cephalograms, and the obtained data was compared with that of Caucasian.

[Selection and anti-cancer effects of siRNAs targeting HMGA2 gene].

High mobility group A2 protein (HMGA2), an architectural factor, is highly expressed in various cancer types including lung cancers. It is a candidate target for cancer therapy. RNAi is an effective gene silencing method with low cost and less time-consuming.

Double-stranded Let-7 mimics, potential candidates for cancer gene therapy.

MicroRNAs (miRNAs), a class of small, single-stranded endogenous RNAs, act as post-transcriptional regulators of gene expression. The ability of one single miRNA regulating multiple functionally related mRNAs makes it a new potential candidate for cancer gene therapy. Let-7s miRNAs have been demonstrated as tumor-suppressor genes in various types of cancers, providing one choice of gene therapy by replenishing this miRNA.

Correlation of 4-month infant feeding modes with their growth and iron status in Beijing.

Background: Growth and development of infants has been an important topic in pediatrics for a long time. Infants must be provided with food containing all necessary nutrients. Breast milk is believed to be the most desirable natural and cheapest food for well-balanced nutrition.

[To explore the clinical significance of HBV large protein (HBV-LP) in diagnosing viral replication].

Objective: To explore the clinical significance of HBV large protein (HBV-LP) in diagnosing viral replication, we detected the HBV-LP, HBV DNA and the hepatitis B viral markers (HBV M) in the serum of the patients infected with HBV.

Methods: HBV-LP and HBV M were analyzed by using ELISA. HBV-DNA was quantitatively detected using real-time fluorescent polymerase chain reaction.

Detection of hepatitis B virus genotypes using oligonucleotide chip among hepatitis B virus carriers in Eastern China.

Aim: To determine the genotype distribution of hepatitis B virus (HBV) with a newly oligonucleotide chip assay among the HBV carriers in Eastern China.

Methods: An assay using oligonucleotide chip was developed for detection of HBV genotypes in serum samples from HBV DNA-positive patients in Eastern China. This method is based on the principle of reverse hybridization with Cy5-labeled amplicons hybridizing to type-specific oligonucleotide probes that are immobilized on slides.