Posttranscriptional Control of Neural Progenitors Temporal Dynamics During Neocortical Development by Syncrip.

The development of the mammalian neocortex is precisely regulated by temporal gene expression, yet the temporal regulatory mechanisms of cortical neurogenesis, particularly how radial glial cells (RGCs) sequentially generate deep to superficial neurons, remain unclear. Here, the hnRNP family member Syncrip (hnRNP Q) is identified as a key modulator of superficial neuronal differentiation in neocortical neurogenesis. Syncrip knockout in RGCs disrupts differentiation and abnormal neuronal localization, ultimately resulting in superficial cortical layer defects as well as learning and memory impairments in mice.

Design of an endoscopic OCT probe based on piezoelectric tube with quartered outside electrodes.

Optical coherence tomography (OCT) is a pivotal imaging modality in ophthalmology for real-time, visualization of retinal structures. To enhance the capability and safety of OCT, this study focuses on the development of a micro intraocular OCT probe. The demand for minimal invasiveness and precise imaging drives the need for advanced probe designs that can access tight and sensitive areas, such as the ocular sclera.

A preliminary study of optimal treatment response rates in patients undergoing hepatic arterial infusion chemotherapy combined with molecular targeting and immunotherapy.

Objectives: This study aimed to examine the effectiveness of the best response rate (BRR) as a surrogate for overall survival (OS), using the modified Response Evaluation Criteria in Solid Tumors (mRECIST), in patients with unresectable hepatocellular carcinoma (HCC) undergoing hepatic arterial infusion chemotherapy (HAIC) with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) combined with molecular targeting and immunotherapy.

Methods: This study enrolled 111 consecutive patients who had complete imaging data. The median age of patients was 58 years (IQR 50.

Fabrication of High-Performance Densified Wood via High-Pressure Steam Treatment and Hot-Pressing.

The fabrication of sustainable structural materials with high physical properties to replace engineering plastics is a major challenge for modern industry, and wood, as the most abundant sustainable natural raw material on the planet, has received a great deal of attention from researchers. Researchers have made efforts to enhance the physical properties of wood in order to replace plastics. However, it is also difficult to meet practical demands at a low cost.

Network dynamics underlying alterations in apparent object size.

A target circle surrounded by small circles looks larger than an identical circle surrounded by large circles (termed as the Ebbinghaus illusion). While previous research has shown that both early and high-level visual regions are involved in the generation of the illusion, it remains unclear how these regions work together to modulate the illusion effect. Here, we used functional MRI and dynamic causal modelling to investigate the neural networks underlying the illusion in conditions where the focus of attention was manipulated via participants directing their attention to and maintain fixation on only one of the two illusory configurations at a time.

DMGL-MDA: A dual-modal graph learning method for microbe-drug association prediction.

The interaction between human microbes and drugs can significantly impact human physiological functions. It is crucial to identify potential microbe-drug associations (MDAs) before drug administration. However, conventional biological experiments to predict MDAs are plagued by drawbacks such as time-consuming, high costs, and potential risks.

Design and evaluation of a wearable vascular interventional surgical robot system.

Background: Remote-controlled robotic vascular interventional surgery can reduce radiation exposure to interventional physicians and improve safety. However, inconvenient operation and lack of force feedback limit its application.

Materials And Methods: A new wearable robotic system for vascular interventional surgery is designed, which is more flexible in operation.

Corrigendum: Induction of RIPK3/MLKL-mediated necroptosis by injection exhibits potent antitumor effect.

[This corrects the article DOI: 10.3389/fphar.2023.

Suppression of MUC1-Overexpressing Tumors by a Novel MUC1/CD3 Bispecific Antibody.

Mucin1 (MUC1) is abnormally glycosylated and overexpressed in a variety of epithelial cancers and plays a critical role in tumor progression. MUC1 has received remark attention as an oncogenic molecule and is considered a valuable tumor target for immunotherapy, while many monoclonal antibodies (mAbs) targeting MUC1-positive cancers in clinical studies lack satisfactory results. It would be highly desirable to develop an effective therapy against MUC1-expressing cancers.

Lossless Reversible Data Hiding in Encrypted Image for Multiple Data Hiders Based on Pixel Value Order and Secret Sharing.

Reversible data hiding in encrypted images (RDH-EI) is instrumental in image privacy protection and data embedding. However, conventional RDH-EI models, involving image providers, data hiders, and receivers, limit the number of data hiders to one, which restricts its applicability in scenarios requiring multiple data embedders. Therefore, the need for an RDH-EI accommodating multiple data hiders, especially for copyright protection, has become crucial.

Induction of RIPK3/MLKL-mediated necroptosis by Erigeron breviscapus injection exhibits potent antitumor effect.

Colorectal cancer (CRC) is the second leading cause of tumor-related deaths worldwide. Resistance of tumor cells to drug-induced apoptosis highlights the need for safe and effective antitumor alternatives. Erigeron breviscapus (Dengzhanxixin in China) injection (EBI), extracted from the natural herb (EHM), has been widely used in clinical practice for cardiovascular diseases.

Characterization of nuclear DNA diversity in an individual .

Intraorganismal genetic heterogeneity (IGH) exists when an individual organism harbors more than one genotype among its cells. In general, intercellular DNA diversity occurs at a very low frequency and cannot be directly detected by DNA sequencing from bulk tissue. In this study, based on Sanger and high-throughput sequencing, different species, different organs, different DNA segments and a single cell were employed to characterize nucleotide mutations in Leymus chinensis.

Design and Control for WLR-3P: A Hydraulic Wheel-Legged Robot.

The robot used for disaster rescue or field exploration requires the ability of fast moving on flat road and adaptability on complex terrain. The hybrid wheel-legged robot (WLR-3P, prototype of the third-generation hydraulic wheel-legged robot) has the characteristics of fast and efficient mobility on flat surfaces and high environmental adaptability on rough terrains. In this paper, 3 design requirements are proposed to improve the mobility and environmental adaptability of the robot.

Hyperspectral Image Denoising: From Model-Driven, Data-Driven, to Model-Data-Driven.

Mixed noise pollution in HSI severely disturbs subsequent interpretations and applications. In this technical review, we first give the noise analysis in different noisy HSIs and conclude crucial points for programming HSI denoising algorithms. Then, a general HSI restoration model is formulated for optimization.

MiR-92a expression profiling of exfoliated colonocytes isolated from feces for colorectal cancer screening.

Objective: This study seeks to assess the efficacy of exfoliated colonocytes isolated from feces (ECIF) miR-92a as a clinical colorectal cancer diagnostic marker in a larger cohort.

Methods: Clinicopathologic data from colorectal cancer patients and health controls that underwent colonoscopy, as well as patients of other cancers diagnosed, were included. A total of 963 Chinese participants were enrolled, with 292 (27.

Research on application of helmet wearing detection improved by YOLOv4 algorithm.

Aiming at the problem that the model of YOLOv4 algorithm has too many parameters and the detection effect of small targets is poor, this paper proposes an improved helmet fitting detection model based on YOLOv4 algorithm. Firstly, this model improves the detection accuracy of small targets by adding multi-scale prediction and improving the structure of PANet network. Then, the improved depth-separable convolution was used to replace the standard 3 × 3 convolution, which greatly reduced the model parameters without reducing the detection ability of the model.

Design and evaluation of vascular interventional robot system for complex coronary artery lesions.

At present, most vascular intervention robots cannot cope with the more common coronary complex lesions in the clinic. Moreover, the lack of effective force feedback increases the risk of surgery. In this paper, a vascular interventional robot that can collaboratively deliver multiple interventional instruments has been developed to assist doctors in the operation of complex lesions.

Photodynamic therapy treats acne by altering the composition of the skin microbiota.

Background: Acne is the eighth-most prevalent inflammatory skin disease with no optimal treatment. Photodynamic therapy (PDT) is an effective treatment for severe acne.

Aims: The effect of PDT on the composition and diversity of skin microflora in severe acne patients was studied.

Study on In-Situ Tool Wear Detection during Micro End Milling Based on Machine Vision.

Most in situ tool wear monitoring methods during micro end milling rely on signals captured from the machining process to evaluate tool wear behavior; accurate positioning in the tool wear region and direct measurement of the level of wear are difficult to achieve. In this paper, an in situ monitoring system based on machine vision is designed and established to monitor tool wear behavior in micro end milling of titanium alloy Ti6Al4V. Meanwhile, types of tool wear zones during micro end milling are discussed and analyzed to obtain indicators for evaluating wear behavior.

Association between dietary inflammation and erectile dysfunction among US adults: A cross-sectional analysis of the National Health and Nutrition Examination Survey 2001-2004.

Background: Although chronic low-grade inflammation has been linked to the development of erectile dysfunction (ED), the association between pro-inflammatory diets and ED is unclear. The dietary inflammation index (DII) is a novel method to quantify the inflammatory potential of a diet.

Objective: Our objective was to investigate the association between the DII and ED among US males.