Protective Effects of Chitosan Oligosaccharide Against Lipopolysaccharide-Induced Inflammatory Response and Oxidative Stress in Bovine Mammary Epithelial Cells.

Chitosan oligosaccharide (COS) is receiving increasing attention as a feed additive in animal production. COS has a variety of biological functions, including anti-inflammatory and antioxidant activities. Mastitis is a major disease in dairy cows that has a significant impact on animal welfare and production.

Attention-Based Interpretable Multiscale Graph Neural Network for MOFs.

Metal-organic frameworks (MOFs) hold great potential in gas separation and storage. Graph neural networks (GNNs) have proven effective in exploring structure-property relationships and discovering new MOF structures. Unlike molecular graphs, crystal graphs must consider the periodicity and patterns.

Effectiveness of different traditional Chinese medicine injections in patients with diabetic lower extremity arterial disease: A Bayesian network meta-analysis.

Background And Purpose: Numerous studies have demonstrated the effectiveness of Chinese medicine injections (CMIs) in treating diabetic lower extremity arterial disease (Dia-LEAD). However, with the variety of CMIs available, it has become challenging to determine the optimal choice for Dia-LEAD patients. This study aims to compare and rank the efficacy of CMIs for Dia-LEAD to provide references and evidence for clinicians in optimising drug selection.

The underestimated environmental risk of tris (2-chloroethyl) phosphate photodegradation in aqueous environment induced by polystyrene microplastics.

Tris(2-choroethyl) phosphate (TCEP) is commonly utilized as a flame retardant and plasticizer, which inevitably coexists with polystyrene microplastics (PS-MPs) in aquatic environments. In this work, the promoting effect of pristine and aged PS-MPs on the photodegradation of TCEP was observed, and the reaction mechanisms and environmental risks of PS-MPs enhancing TCEP photodegradation were clearly revealed. The aged PS-MPs presenting more significant enhancement was attributed to more generation of reactive oxygen species (ROS).

Vapor-Deposited High-Entropy Metallic Glasses.

Physical vapor deposition (PVD) at an appropriate temperature has been shown to produce ultrastable glass by the mechanism of surface accelerated diffusion. Recently, high-entropy materials have been discovered to display slower atomic diffusion due to the multicomponent high-entropy effects. How this delayed atomic motion influences the formation and stability of PVD glass remains elusive.

The arch myth: investigating the impact of flat foot on vertical jump height: a systematic review and meta-analysis.

Objective: The necessity to exclude flat foot when selecting athletes is a controversial issue. This study aimed to investigate whether flat foot affects vertical jump.

Methods: The quality of the literature was assessed using the observational study quality assessment tool provided by the Joanna Briggs Institute (JBI) Centre for Evidence-Based Health Care in Australia.

Effects of Genetic Polymorphism in the Gene on Milk Fat Traits and Relevance to Lipid Metabolism in Bovine Mammary Epithelial Cells.

Milk fat is an important indicator for evaluating milk quality and a symbol of the core competitiveness of the dairy industry. It can be improved through genetic and feed management factors. Interferon alpha-inducible protein 27 () was found to be differentially expressed when comparing the transcriptome in high- and low-fat bovine mammary epithelial cells (bMECs) in our previous research.

Interdisciplinary Innovations and Applications of Bionics and Bioengineering in Kinesiology.

Kinesiology, as an interdisciplinary field, emphasizes the study of human physical activity, with a particular focus on biomechanics and sports science [...

CD74 fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloids.

The healing of human skin wounds is susceptible to perturbation caused by excessive mechanical stretching, resulting in enlarged scars, hypertrophic scars, or even keloids in predisposed individuals. Keloids are fibro-proliferative scar tissues that extend beyond the initial wound boundary, consisting of the actively progressing periphery and the quiescent center. The stretch-associated outgrowth and enhanced angiogenesis are two features of the periphery of keloids.

PresRecRF: Herbal prescription recommendation via the representation fusion of large TCM semantics and molecular knowledge.

Background: Herbal prescription recommendation (HPR) is a hotspot in the research of clinical intelligent decision support. Recently plentiful HPR models based on deep neural networks have been proposed. Owing to insufficient data, e.

Island biogeography theory and the habitat heterogeneity jointly explain global patterns of diversity.

Mountain biodiversity is of great importance to biogeography and ecology. However, it is unclear what ecological and evolutionary processes best explain the generation and maintenance of its high levels of species diversity. In this study, we determined which of six common hypotheses (e.

Exploring the causal relationship between plasma lipids and varicose veins of lower extremity: A comprehensive two-sample Mendelian randomization study.

Varicose veins of the lower extremities (VVs) is a common chronic vascular disease, with high prevalence rates in some countries; however, their pathogenesis remains unclear. Some studies have identified associations between changes in specific plasma lipid molecules, such as phosphatidylethanolamine (PE), phosphatidylcholine (PC), and sphingomyelin (SM), and the onset of VVs, but due to confounders and reverse causality, the causal relationship remains unclear. Meanwhile, studies on the potential link between other plasma lipids beyond PE, PC, and SM and the risk of VVs in the lower extremities are lacking.

Alloy Reconstruction in Pyrolytic Bowknot-like Heteronuclear CoFe Clusters for Electrocatalytic Application.

The construction of doped molecular clusters is an intriguing way to perform bimetallic doping for electrocatalysts. However, efficiently harnessing the benefits of a doping strategy and alloy engineering to create a nanostructure for electrocatalytic application at the molecular level has consistently posed a challenge. Here we propose an in situ reconstruction strategy aimed at producing an alloy nanostructure through a pyrolysis process, originating from bowknot-like heterometallic clusters.

Effect of Hepatic Impairment on the Pharmacokinetics and Pharmacodynamics of SHR4640, a Selective Human Urate Transporter 1 Inhibitor.

This parallel-group, open-label Phase I study evaluated the effect of mild to moderate hepatic impairment on pharmacokinetics (PK), pharmacodynamics (PD), and safety of a single oral dose of SHR4640. Participants with mild or moderate hepatic impairment were enrolled, with each cohort consisting of eight individuals, alongside eight well-matched controls with normal hepatic function. The participants were administered 10 mg SHR4640, and blood samples were collected for PK evaluation over 72 h.

Application of S-transform-based nonlinear processing for accurate LIBS quantitative analysis of iron ore slurry.

Real-time Fe content monitoring in iron ore slurry is crucial for evaluating concentrate quality and enhancing mineral processing efficiency. Laser-induced breakdown spectroscopy (LIBS) is a promising technique for the online monitoring of elemental content at industrial sites. However, LIBS measurements are hampered by the matrix effect and the self-absorption effect, limiting the precision of linear analytical processes.

Amorphous conversion in pyrolytic symmetric trinuclear nickel clusters trigger trifunctional electrocatalysts.

The pursuit of multifunctional electrocatalysts holds significant importance due to their comprehension of material chemistry. Amorphous materials are particularly appealing, yet they pose challenges in terms of rational design due to their structural disorder and thermal instability. Herein, we propose a strategy that entails the tandem (low-temperature/250-350 °C) pyrolysis of molecular clusters, enabling preservation of the local short-range structures of the precursor Schiff base nickel (Ni[2(CHNNiO)]).

Predicting the pathways of string-like motions in metallic glasses via path-featurizing graph neural networks.

String-like motions (SLMs)-cooperative, "snake"-like movements of particles-are crucial for dynamics in diverse glass formers. Despite their ubiquity, questions persist: Do SLMs prefer specific paths? If so, can we predict these paths? Here, in Al-Sm glasses, our isoconfigurational ensemble simulations reveal that SLMs do follow certain paths. By designing a graph neural network (GNN) to featurize the environment around directional paths, we achieve a high-fidelity prediction of likely SLM pathways, solely based on the static structure.

Tissue-specific GlcNAcylation profiling identifies substrates in translational machinery in mushroom body contributing to olfactory learning.

GlcNAcylation is a dynamic post-translational modification that diversifies the proteome. Its dysregulation is associated with neurological disorders that impair cognitive function, and yet identification of phenotype-relevant candidate substrates in a brain-region specific manner remains unfeasible. By combining an GlcNAc binding activity derived from OGA (OGA) with TurboID proximity labeling in , we developed an GlcNAcylation profiling tool that translates GlcNAc modification into biotin conjugation for tissue-specific candidate substrates enrichment.

PresRecST: a novel herbal prescription recommendation algorithm for real-world patients with integration of syndrome differentiation and treatment planning.

Objectives: Herbal prescription recommendation (HPR) is a hot topic and challenging issue in field of clinical decision support of traditional Chinese medicine (TCM). However, almost all previous HPR methods have not adhered to the clinical principles of syndrome differentiation and treatment planning of TCM, which has resulted in suboptimal performance and difficulties in application to real-world clinical scenarios.

Materials And Methods: We emphasize the synergy among diagnosis and treatment procedure in real-world TCM clinical settings to propose the PresRecST model, which effectively combines the key components of symptom collection, syndrome differentiation, treatment method determination, and herb recommendation.

Universal origin of glassy relaxation as recognized by configuration pattern matching.

Relaxation processes are crucial for understanding the structural rearrangements of liquids and amorphous materials. However, the overarching principle that governs these processes across vastly different materials remains an open question. Substantial analysis has been carried out based on the motions of individual particles.

[Discussing the basic ecological relations of sand dune vegetation process].

Dune is often considered as a degraded ecosystem. Natural vegetation restoration and stable artificial vegetation construction are the basic means restoring dune ecosystem. Based on long-term study of dune ecosystem, by taking into consideration both the philosophical principles of unity of opposites and dynamic change, and related ecological theories, we put forward some ecological relations that should be paid attention to in the study of vegetation assembly from the perspective of the uniqueness of dune ecosystem.

Effects of sustained viral response on lipid in Hepatitis C: a systematic review and meta-analysis.

Background: Direct-acting Antiviral Agents (DAAs) influence serum lipids of patients with Hepatitis C virus (HCV). This paper presents an analysis of the relevant literature to investigate the effects of DAAs in treating hepatitis C to achieve a sustained viral response (SVR) on lipid parameters.

Methods: PubMed,Web of science, Embase and Central databases were searched, with a deadline of September 2023.