Publications by authors named "Yu Hai"

Japanese encephalitis caused by Japanese encephalitis virus (JEV) infection leads to the central nervous system disorder in human and swine. Viruses utilize the host protein synthesis mechanisms to efficiently translate their RNAs. Herein, we demonstrated that the host transcription factor SOX10 downregulated an RNA-binding protein heterogeneous nuclear ribonucleoprotein H (HNRNPH1) during JEV infection.

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Herein, well-dispersed cobalt phosphide (CoP) electrocatalysts embedded in nitrogen-doped carbon (CoP@NC) were developed as an iodine host for zinc iodine batteries. Benefiting from the high electrical conductivity of the carbon matrix and the strong interaction as well as the efficient electrocatalytic activity of CoP with iodine species, the host achieved rapid iodine conversion while effectively suppressing the formation of polyiodides and zinc dendrites.

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Infection with porcine epidemic diarrhea virus (PEDV) results in enormous economic damage to the global swine industry. PEDV starts its life cycle by binding to the receptors of host cells and adsorbing onto the cellular surfaces. However, it is still unknown how PEDV adsorbs onto the surface of host cells and the mechanism beneath the interplay of host cell transmembrane protein with PEDV proteins.

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  • - The study focuses on cutaneous squamous cell carcinoma (CSCC), which is a type of skin cancer that can recur and spread more aggressively in some cases, making it important to monitor survival rates for better patient care and health strategies.
  • - Conducted using data from the National Cancer Institute's SEER database, the research analyzed information on 204,055 patients diagnosed with CSCC over two decades, from 2000 to 2019.
  • - The researchers assessed patient trends and relative survival rates using a period analysis method to gain insights into the outcomes for people diagnosed with CSCC.
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The liver produces various ketone bodies (KBs) including 3-Hydroxybutyrate (3-OHB), acetoacetate (AcAc), and acetone, with 3-OHB being the major component. Previous studies have shown that KBs protect against respiratory diseases; however, there is no evidence of a genetic link. To avoid biases existing in traditional observational studies, a two-sample Mendelian randomization (MR) analysis was carried out to investigate genetic causation and novel therapeutic uses for KBs.

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  • NMOSD is a rare autoimmune disease affecting the CNS, and this study is the first Phase I clinical trial in Chinese patients testing the safety and efficacy of a new drug called BAT4406F, an anti-CD20 monoclonal antibody.
  • The study involved 15 patients who received different doses of BAT4406F, with results showing no dose-limiting toxicities and mostly mild side effects, indicating a favorable safety profile.
  • The drug demonstrated effective B-cell depletion, important for treating NMOSD, with a nonlinear pharmacokinetic profile and longer elimination half-life, suggesting promising therapeutic potential.
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Neutralizing antibodies (nAbs) play a crucial role in virology, antibody drug development, and vaccine research. In this study, we investigated the synergistic effect of two hepatitis E virus (HEV) nAbs, 8H3, and 8C11, which have exhibited enhanced neutralizing activity in a rhesus monkey model. We presented crystal structures of 8H3 Fab alone and a triple complex of 8C11 Fab and 8H3 Fab simultaneously binding to the HEV E2s protein (8C11:E2s:8H3).

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Respiratory syncytial virus (RSV) poses a significant public health challenge, especially among children. Although palivizumab and nirsevimab, neutralizing antibodies (nAbs) targeting the RSV F protein, have been used for prophylaxis, their limitations underscore the need for more effective alternatives. Herein, we present a potent and broad nAb, named 5B11, which exhibits nanogram level of unbiased neutralizing activities against both RSV-A and -B subgroups.

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  • The study aimed to compare the effects of two different fractions of inspired oxygen (30% vs 80%) on pulmonary complications in patients undergoing open abdominal surgery, using a driving pressure-guided ventilation strategy.
  • Conducted at a university hospital in China, the research involved 514 adult patients who were randomly assigned to each oxygen level during their surgery.
  • Results indicated that patients receiving 30% FIO had a significantly lower rate of postoperative pulmonary complications and better dynamic compliance than those receiving 80% FIO.
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The continual emergence of highly pathogenic novel coronaviruses and their variants has underscored the importance of neutralizing monoclonal antibodies (mAbs) as a pivotal therapeutic approach. In the present study, we report the specific neutralizing antibodies 13H7 and 9G11, which target the N-terminal domain (NTD) and receptor-binding domain (RBD) of the SARS-CoV-2, respectively. The comparative analysis observed that 13H7 not only neutralizes early variants of concern (VOCs) but also exhibits neutralizing activity against the Omicron sublineage, including BA.

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  • Prophylactic corticosteroids are commonly used to manage inflammation from cardiopulmonary bypass in infants, but their effect on key clinical outcomes is unclear.
  • A review of eight randomized controlled trials, involving 1,920 infants, found no significant differences in postoperative mortality, though corticosteroid use led to increased insulin treatment and reduced mechanical ventilation time.
  • The study concludes that routine use of corticosteroids in cardiac surgery for infants is not supported by current evidence and calls for more research on optimal treatments.
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  • Enteroviruses have various serotypes and can lead to severe neurological issues, complicating the creation of effective treatments and vaccines due to their complex life cycle and interactions with host cells.* -
  • A newly identified antibody, h1A6.2, offers strong protection against enterovirus A71 and coxsackievirus A16 in mice, working through multiple mechanisms that reduce inflammation and enhance tissue repair.* -
  • Advanced imaging techniques reveal that h1A6.2 binds adaptively to a key part of the virus, allowing it to neutralize different enterovirus types effectively, making it a promising candidate for future pan-enterovirus vaccine development.*
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  • The study investigates how cytochrome c (Cyt-c) adsorbs onto five types of self-assembled monolayers (SAMs) through simulations, focusing on factors like surface chemistry and charge density.
  • Cyt-c displays strong binding to CH3-SAM due to hydrophobic interactions while encountering weak adsorption on OH-SAM; lower charge density NH2-SAM does not support stable binding under high ionic conditions.
  • The structural integrity of Cyt-c is generally maintained on most SAMs, but its redox properties are compromised on highly negative OSO3--SAM surfaces due to changes in orientation and conformation.
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Multi-Label Text Classification (MLTC) is a crucial task in natural language processing. Compared to single-label text classification, MLTC is more challenging due to its vast collection of labels which include extracting local semantic information, learning label correlations, and solving label data imbalance problems. This paper proposes a model of Label Attention and Correlation Networks (LACN) to address the challenges of classifying multi-label text and enhance classification performance.

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The diffusion phenomenon that exhibits intrinsic similarities is pervasive in cryptography and natural systems, evident in liquid diffusion, epidemic spread, animal migration, and encryption techniques. In cryptography, bytes are systematically diffused in a sequential manner to encrypt the value of each byte in the plaintext in a linear fashion. In contrast, within an epidemic spreading model, the diffusion process can be represented within a complex, multilayered network, encompassing layers such as familial and social transmission dynamics.

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  • Three types of protein emulsions (myofibrillar protein, soy protein isolate, and egg white protein isolate) were combined to create composite gels.
  • N-ethylmaleimide (NEM) was used to block sulfhydryl groups, allowing researchers to study how sulfhydryl and disulfide bonds affected the gels' properties.
  • Results indicated that as NEM increased, the disulfide bond content and overall strength of the gels decreased, while the microstructure showed that the protein membranes in the emulsions were damaged, leading to reduced gel quality.
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Background: The effect of different mechanical ventilation modes on pulmonary outcome after abdominal surgery remains unclear. We evaluated the effects of three common ventilation modes on postoperative pulmonary complications (PPCs) among intermediate- to high-risk patients undergoing abdominal surgery.

Methods: This randomized clinical trial enrolled adult patients at intermediate or high risk of PPCs who were scheduled for abdominal surgery.

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Unlabelled: Hepatitis B virus (HBV) infection is a significant global health concern due to elevated immunosuppressive viral antigen levels, the host immune system's inability to manage HBV, and the liver's immunosuppressive conditions. While immunotherapies utilizing broadly reactive HBV neutralizing antibodies present potential due to their antiviral capabilities and Fc-dependent vaccinal effects, they necessitate prolonged and frequent dosing to achieve optimal therapeutic outcomes. Toll-like receptor 7/8 (TLR7/8) agonists have been demonstrated promise for the cure of chronic hepatitis B, but their systemic use often leads to intense side effects.

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A new three-dimensional (3D) coordination polymer, namely, poly[diaqua[μ-2,2'-(1,3,5,7-tetraoxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]isoindole-2,6-diyl)diacetato]barium(II)], [Ba(CHNO)(HO)], (I), has been synthesized by the microwave-irradiated reaction of Ba(NO) with N,N'-bis(glycinyl)pyromellitic diimide {BGPD, namely, 2,2'-(1,3,5,7-tetraoxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]isoindole-2,6-diyl)diacetatic acid, HL}. The title compound was structurally characterized by single-crystal X-ray diffraction analysis and powder X-ray diffraction analysis, as well as IR spectroscopy. In the crystal structure of (I), the Ba ion is nine-coordinated by six carboxylate O atoms from five symmetry-related L dianions and one imide O atom, as well as two water O atoms.

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Two new two-dimensional (2D) coordination polymers (CPs), namely, poly[diaqua[μ-2,2'-(1,3,5,7-tetraoxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]isoindole-2,6-diyl)diacetato-κO:O':O'':O''']cadmium(II)], [Cd(CHNO)(HO)] (1), and poly[[tetraaqua[μ-2,2'-(1,3,5,7-tetraoxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]isoindole-2,6-diyl)diacetato-κO:O':O'':O'''][μ-2,2'-(1,3,5,7-tetraoxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]isoindole-2,6-diyl)diacetato-κO:O']dizinc(II)] dihydrate], {[Zn(CHNO(HO)]·HO} (2), have been synthesized by the microwave-irradiated reaction of Cd(CHCOO)·2HO and Zn(CHCOO)·2HO, respectively, with N,N'-bis(glycinyl)pyromellitic diimide {BGPD, namely, 2,2'-(1,3,5,7-tetraoxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]isoindole-2,6-diyl)diacetic acid, HL}. In the crystal structure of 1, the Cd ion is six-coordinated by four carboxylate O atoms from four symmetry-related L dianions and two coordinated water molecules, furnishing an octahedral coordination geometry. The bridging L dianion links four symmetry-related Cd cations into a 2D layer-like structure with a 3,4-connected bex topology.

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Utilizing the design of heterojunction structures formed between photocatalysts to enhance photoelectrochemical performance represents an effective strategy for improving the efficiency of photocatalytic hydrogen production. In this work, a straightforward one-step solvothermal method was employed to embed NENU-5 nano-octahedra within ZnInS nanoflowers, forming ZnInS@NENU-5 heterostructures. Hydrogen production tests conducted over 5 h revealed a hydrogen evolution activity of 5282.

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  • * Using multi-variable linear regression, researchers identified 28 variables affecting FEI, with 18 showing significant correlations; these factors persisted from the nursery stage to the finishing stage.
  • * High-performing batches of pigs differed from low-performing batches in aspects such as sourcing of piglets, regional purchasing, and the implementation of farm technologies like CCTV and waste management systems.
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The presence and the level of antibodies in human sera against bacterial glycans are indications of prior encounters with similar antigens and/or the bacteria that express them by the immune system. An increasing number of pathogenic bacteria that cause human diseases have been shown to express polysaccharides containing a bacterial nonulosonic acid called 5,7-di--acetyllegionaminic acid (Leg5,7Ac). To investigate the immune recognition of Leg5,7Ac, which is critical for the fight against bacterial infections, a highly effective chemoenzymatic synthon strategy was applied to construct a library of α2-3/6-linked Leg5,7Ac-glycans via their diazido-derivatives (Leg5,7diN-glycans) formed by efficient one-pot three-enzyme (OP3E) synthetic systems from a diazido-derivative of a six-carbon monosaccharide precursor.

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  • The objective of the study was to summarize existing research on genetic variants linked to nonalcoholic fatty liver disease (NAFLD).
  • A systematic search of literature from various databases yielded 399 studies, leading to the identification of 465 genetic variants across many genes.
  • The meta-analysis found 11 significant genetic variants associated with NAFLD, providing moderate to strong evidence for six variants in five genes that could enhance understanding of NAFLD risk.
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