[Prevalence and risk factors of delirium in COVID-19].

Objective: To assess the frequency and risk factors of delirium in patients hospitalized with COVID-19.

Material And Methods: Four hundred and forty patients admitted to the Infectious Diseases Hospital of the University Clinical Hospital No.3 of Sechenov University were included in the study.

[The current state and future prospects of depression research (clinical and classification problems)].

Despite decades of research, neurobiological studies of depression haven't achieved significant results. Many experts propose that one of the main reasons for this failure is current diagnostic standards not considering the heterogeneity and polymorphism of depression. Research is unable to identify specific neurobiological changes due to formal diagnosis 'major depressive disorder' and new diagnostic criteria are needed.

[Genetic and clinical predictors of treatment efficacy in depressive disorders].

Aim: To study clinical and genetic characteristics that impact on the efficacy of pharmacotherapy of depressive disorders.

Material And Methods: The study included 188 patients with unipolar depressive disorders of different genesis (psychogenic, endogenous and organic). A clinical-psychopathological method and depression psychometric scales were used.

[An increase in the efficacy of psychopharmacotherapy of late-onset depressions: combination and substitution of antidepressants].

Objective: To comprehensively analyze the possibilities of using the methods of correction of non-effective psychopharmacotherapy of late-onset depressions.

Material And Methods: Methods of potentiating, combination and substitution of non-effective psychopharmacotherapy of late-onset depressions were studied.

Results And Conclusion: Indications to the use and specific algorithms of substitution and addition of antidepressants in non-effective psychopharmacotherapy of late-onset depressions have been developed.

[The efficacy of psychopharmacotherapy of late onset depression: the optimization of treatment duration].

Objective: To analyze possibilities of using different methods to increase the efficacy of psychopharmacotherapy of late onset depression, in particular to increase treatment duration.

Material And Methods: The study included 378patients, aged from 50 to 82 years (mean age 60.6±8.

[The association between the 5-HTTLPR polymorphism of the serotonin transporter gene and the efficacy and tolerability of selective serotonin reuptake inhibitors].

Objective: To search for the association between the 5-HTTLPR polymorphism of the serotonin transporter gene and the efficacy and tolerability of selective serotonin reuptake inhibitors (SSRIs).

Material And Methods: The complex clinical/psychopathological and genetic study of 38 patients with depression treated with SSRIs was carried out.

Results And Conclusion: The 5-HTTLPR polymorphism was associated with the rate of achievement of remission and tolerability of treatment: carriers of the SS genotype achieved remission less frequently and more frequently experienced side-effects.

[Remote consequences of the long-term uncontrollable consumption of anxiolytics and hypnotics in elderly: a problem of drug dependence].

Aim: To identify main clinical/psychopathological characteristics of aged psychiatric inpatients who regularly used anxiolytic and hypnotic benzodiazepines without control from the physician.

Material And Methods: Authors examined 56 women over 50 years hospitalized due to a psychiatric disorder. Before admission, they regularly used benzodiazepines without a prescription for more than 2 months.

[Current state and potential of pharmacogenetic studies in the treatment of depression].

In this literature review, we consider pharmacological studies in the aspect of functioning of cerebral neurochemical systems and their role in the development of depression and mechanisms of antidepressant action. The following sections of the review are devoted to the above issues: adrenoreceptors, serotonin transporter protein, dopamine transporter protein, monoamine oxidase A, catechol-O-methyltransferase, brain-derived neurotrophic factor, the hypothalamic-pituitary-adrenal system, G-proteins, the glutamatergic system.

[Venlafaxine in the treatment of moderate and severe depressions: the ways to increase treatment efficacy].

Objective: To find factors influencing the efficacy of venlafaxine in moderate and severe depressions.

Material And Methods: An observational study was carried out in real clinical practice. We examined 62 patients with depression, 21 men and 41 women, aged from 19 to 61 years, treated with venlafaxine.

[Treatment of depression: the current state and perspectives of the development of pharmacological studies].

A review of literature over the last two decades is presented. It is emphasized that psyachopharmacotherapy currently remains a main method of treatment of severe and moderate depression. Pharmacogenetic studies are directed mainly towards the identification of probable targets based on pharmacokinetcs and pharmacodynamics of andidepressants as well as the aspect of identification of probably predictors for treatment response.