Publications by authors named "Yu Fan"

Tartary buckwheat is characterized by its numerous inflorescences; however, the uneven distribution of resources can lead to an overload in certain areas, significantly limiting plant productivity. Plant growth regulators effectively modulate plant growth and development. This study investigated the effects of three concentrations of brassinosteroids (EBR) on the Tartary buckwheat cultivar with high seed-setting rates, specifically Chuanqiao No.

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Impaired β cell function is a hallmark of type 2 diabetes (T2D), but the underlying cellular signaling machineries that regulate β cell function remain unknown. Here, we identify that the interleukin-22 receptor subunit alpha 1 (IL-22RA1), known as a co-receptor for IL-22, is downregulated in human and mouse T2D β cells. Mice with β cell Il22ra1 knockout (Il22ra1βKO) exhibit defective insulin secretion and impaired glucose tolerance after being fed a high-fat diet (HFD) or an HFD/low dose of streptozotocin (STZ).

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Background: Peripheral lymphocyte subsets play vital roles in various disease conditions. However, the roles of kidney transplant recipients (KTRs) with novel coronavirus pneumonia (COVID-19) are still unclear. In this research, we investigated the predictive value of peripheral blood lymphocyte subsets on the severity of KTRs with COVID-19 and the correlation between antibodies and lymphocyte levels.

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Objective: This study aimed to systematically review published randomized controlled trials on the effects of physical exercise on activities of daily living (ADL) in Alzheimer's patients through meta-analysis, thereby synthesizing existing evidence to provide scientific intervention recommendations for exercise prescriptions in Alzheimer's patients.

Methods: Based on strict literature inclusion and exclusion criteria, a systematic search was conducted in databases including PubMed and Web of Science from their inception to July 1, 2024. The Cochrane risk assessment tool was used to evaluate the design of randomized controlled trials.

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Ecosystem services and their accounting frameworks have been extensively studied. Snow, as a special climatic product, can provides essential resources and services for human well-being and socioeconomic development which is often ignored. However, the services and value it provides have not been effectively evaluated.

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Background: Chimeric antigen receptor (CAR) T cells have demonstrated remarkable breakthroughs in treating hematologic malignancies, yet their efficacy in solid tumors is limited by the immunosuppressive microenvironment. Sympathetic nerves significantly contribute to this immunosuppressive milieu in solid tumors. However, the impact of tumor sympathetic denervation on enhancing CAR T-cell antitumor efficacy remains unclear.

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  • The study identified 23 three-amino-acid-loop-extension (SbTALE) genes in sorghum, classifying them into KNOX and BEL1-like families and locating them on ten chromosomes.
  • It revealed high conservation of gene structures and motifs among SbTALE subfamilies, while also finding close evolutionary ties with corn (Zea mays) and evidence of gene duplication.
  • The expression patterns of these genes varied across different plant parts and environmental conditions, suggesting their roles in growth regulation and responses to stress, providing a foundation for further research on plant resilience traits.
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Obesity is associated with the gut microbiome. Here, we report that gut commensal Clostridia bacteria regulate host energy balance through the tryptophan-derived metabolite indole-3-propionic acid (IPA). IPA acts as an endogenous leptin sensitiser to counteract obesity.

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While nanopore sequencing is increasingly used for mapping DNA modifications, it is important to recognize false positive calls as they can mislead biological interpretations. To assist biologists and methods developers, we describe a framework for rigorous evaluation that highlights the use of false discovery rate with rationally designed negative controls capturing both general background and confounding modifications. Our critical assessment across multiple forms of DNA modifications highlights that while nanopore sequencing performs reliably for high-abundance modifications, including 5-methylcytosine (5mC) at CpG sites in mammalian cells and 5-hydroxymethylcytosine (5hmC) in mammalian brain cells, it makes a significant proportion of false positive detections for low-abundance modifications, such as 5mC at CpH sites, 5hmC and N6-methyldeoxyadenine (6mA) in most mammal cell types.

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The preparation of polyethylene terephthalate(PET)-based Carbon Dots (PET-CDs) using one-step hydrothermal method with PET waste, pyromellitic acid (PMA) and ammonia (NH·HO) as precursors is a high-value utilization strategy for PET waste, offering significant application potential. To achieve efficient recycling of PET waste, response surface methodology was adopted for to optimize the precursor ratio during the synthesis of PET-CDs with fluorescence quantum yield (QY) as the key performance indicator. The optimal preparation conditions were determined to be: 1.

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  • * The study used various microbiological tests and high-throughput sequencing to analyze vaginal microbiota, revealing that women with PPROM had a higher presence of certain bacteria compared to those with normal full-term labor.
  • * Results showed that an abnormal vaginal microbiome, characterized by specific opportunistic bacteria like E. coli and Streptococcus agalactiae, is a crucial risk factor for PPROM, indicating the importance of monitoring vaginal health in pregnancy.
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Considering the close association between cardiac troponin I (cTnI) level and various cardiovascular diseases, it becomes essential to explore sensitive and accurate detection methods for monitoring their levels in the early stages of disease. In this work, a magnetic dual-aptamer electrochemical sensor for cTnI detection was constructed in the first utilizing MOF-on-MOF-derived electrocatalyst as a signal amplifier in collaboration with high-efficient separation of magnetic beads (MBs). Employing zeolitic imidazolate framework-67 (ZIF-67) with high surface area as host MOF, MOF-on-MOF heterostructure (ZIF-67@PBA) was facilely prepared by in-situ growth of conductive prussian blue analogue (PBA) as guest MOF onto the surface of ZIF-67 with a simple ion-exchange method.

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Organic-inorganic halide perovskite single crystals (SCs) have shown great potential in radiation detection applications due to their large radiation stopping power and excellent carrier transport properties. The spatial-confined inverse-temperature crystallization (ITC) method has been widely adopted to obtain large-sized SCs. However, they usually face the problems of uneven stress distribution and high defect density due to the limited crystal growth space and varied growth rate with the increase in temperature, making it difficult to fabricate highly sensitive and stable radiation detectors.

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To develop ultrasensitive and rapid antibiotics residue detection method is crucial for ensuring food safety and protecting human health. Herein, a novel photoelectrochemical (PEC) aptasensor integrated with single-atom ruthenium (Ru) nanozyme-mediated catalytic precipitation as a valuable signal amplification strategy, have been established for ultrasensitive chloramphenicol (CAP) detection. Particularly, the exceptional peroxidase-mimicking activity of single-atom Ru nanozyme is responsible for accelerating the oxidation of 4-chloro-1-naphthol (4-CN) to produce insoluble precipitate on the electrode, which in turn causes a notable reduction in the photocurrent.

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  • * It included over 2,100 T2DM patients, measuring various health metrics like visceral fat area (VFA) and LV function, revealing significant differences between male and female patients in areas such as diabetes duration and cardiovascular health.
  • * Results indicated that for females, higher VFA was linked to decreased left ventricular ejection fraction (LVEF) and higher arterial stiffness (baPWV), while similar patterns were not observed in males, highlighting a sex-specific association in fat distribution and heart health.
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  • The study explored the use of electrical impedance tomography (EIT) to evaluate the impact of thoracic epidural blockade (TEB) combined with general anesthesia on lung function during one-lung ventilation (OLV) in patients undergoing thoracic surgery.
  • Thirty patients were randomly assigned to either a control group or a TEB group, where EIT measurements and blood gas analysis were performed to assess pulmonary perfusion distribution and ventilation-perfusion (V/Q) matching at different stages of the procedure.
  • Results indicated that TEB significantly decreased mean arterial pressure and worsened arterial oxygen levels and shunt percentages during OLV, suggesting it adversely affected respiratory function in these patients.
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Retrons, found in bacteria and used for defense against phages, generate a unique molecule known as multicopy single-stranded DNA (msDNA). This msDNA mimics Okazaki fragments during DNA replication, making it a promising tool for targeted gene editing in prokaryotes. However, existing retron systems often exhibit suboptimal editing efficiency.

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  • * Graphdiyne (GDY), a newly synthesized 2D carbon allotrope, is introduced as a potential catalyst due to its unique structural properties and stability, which may surpass those of graphene.
  • * The review covers GDY's synthesis, properties, applications in photocatalysis, and future research opportunities, while also addressing the challenges faced in developing GDY-based photocatalysts for hydrogen evolution.
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A phosphine-catalyzed [4 + 1] annulation of β'-acetoxy allenoate with α-alkylidene succinimides is described. This method demonstrates the nucleophilic dialkylation and cyclization of α-alkylidene succinimides, resulting in the formation of functionalized spirosuccinimide derivatives. The reaction exhibits a wide substrate scope and yields ranging from moderate to excellent under the optimized conditions.

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Microplastics can accumulate in the excess sludge from wastewater treatment plants through domestic wastewater. This study investigated the co-pyrolysis behavior of sewage sludge coexisting with two types of microplastics (polyethylene (PE) and polylactic acid (PLA)) and found a superior comprehensive pyrolysis performance. By calculating the difference between theoretical and experimental weight loss during the pyrolysis process, it was found that the incorporation of microplastics PE and PLA created a synergistic effect at 270°C-450 °C, which was confirmed through the Malek method analysis from a pyrolysis mechanism perspective that it could increase the random nuclei on each particle, that is, enhance the heterogeneous diffusion of volatiles.

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  • Neuropsychiatric systemic lupus erythematosus (NPSLE) leads to cognitive decline, with activated microglia and disrupted blood-brain barrier (BBB) being key factors, and WIF-1 (a secreted protein) is found in the cerebrospinal fluid of affected patients.
  • Research using lupus-prone mice reveals that injecting WIF-1 worsens cognitive and mood issues, increases BBB leakage, and causes abnormal microglial activation, while reducing WIF-1 shows improvement in symptoms.
  • The study suggests that WIF-1 contributes to cognitive dysfunction through a specific pathway (CRYAB/STAT4-SHH), and indicates that symmetric dimethylarginine (SDMA) can
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Mammalian voltage-gated calcium channels (Ca) play critical roles in cardiac excitability, synaptic transmission, and gene transcription. Dysfunctions in Ca are implicated in a variety of cardiac and neurodevelopmental disorders. Current pharmacological approaches to enhance Ca activity are limited by off-target effects, drug metabolism issues, cytotoxicity, and imprecise modulation.

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