Advanced numerical simulations considering crack orientation for fatigue damage quantification using nonlinear guided waves.

A numerical study including a fatigue crack trajectory simulation was undertaken by means of separating morphing and adaptive remeshing technology (SMART) Crack Growth in ANSYS, on the basis of which the simulations of nonlinear ultrasonic waves for fatigue damage detection using the precise fatigue crack trajectory was achieved. The simulated crack trajectory was first validated by experimental results in terms of crack initiation angle and number of fatigue cycles and was subsequently utilised for crack quantification based on second harmonic method. The results revealed that the nonlinearity in terms of the trend and magnitude with respect to crack length in the advanced simulation is closer to that in the experimental results than the common simulation approach where damage was modelled as a straight line crack.

Novel endogenous angiogenesis inhibitors and their therapeutic potential.

Angiogenesis, the formation of new blood vessels from the pre-existing vasculature is essential for embryonic development and tissue homeostasis. It also plays critical roles in diseases such as cancer and retinopathy. A delicate balance between pro- and anti-angiogenic factors ensures normal physiological homeostasis.

Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes.

The orchestration of histone modifiers is required to establish the epigenomic status that regulates gene expression during development. Whsc1 (Wolf-Hirschhorn Syndrome candidate 1), a histone H3 lysine 36 (H3K36) trimethyltransferase, is one of the major genes associated with Wolf-Hirshhorn syndrome, which is characterized by skeletal abnormalities. However, the role of Whsc1 in skeletal development remains unclear.

The cost of screening adolescents for overweight and hypertension using a community partnership model.

Objectives: (1) Determine the prevalence of overweight and high blood pressure (BP) among middle and high school students over a 2-year period and, (2) measure the cost and initial outcomes of screening.

Design: Cost and outcome description using a cross-sectional design sample. The target population was 12- to 19-year-old healthy students attending grades 7 through 12 at 3 proximal schools located in a large urban school district in Texas.