The method of capillary electrophoresis for quantitative determination of hydrophobized hyaluronic acid in its micellar forms.

Micelles based on hydrophobized hyaluronic acid (HA) are frequently used in targeted drug delivery systems. Capillary zone electrophoresis (CZE) was utilized for the quantitative determination of hydrophobized and native HA. A universal methodology was developed, suitable for the quantitative analysis of amphiphilic derivatives of hyaluronan (oleyl hyaluronan and hyaluronan conjugate with naphthalimide fluorophore) and native HA with varying molecular weights (15, 150, and 800 kDa).

Simultaneous determination of rifabutin and human serum albumin in pharmaceutical formulations by capillary electrophoresis.

Capillary zone electrophoresis (CZE) was used for determination of rifabutin (RFB), an anti-tuberculosis antibiotic drug, in various pharmaceutical formulations. Apart from that, simultaneous determination of RFB and human serum albumin (HSA) was performed. Electrophoretic behaviour of RFB was examined at various pH levels.

The double K+/Ca2+ sensor based on laser scanned silicon transducer (LSST) for multi-component analysis.

In the present work a double ion sensor based on a laser scanned semiconductor transducer (LSST) for the simultaneous determination of K(+)- and Ca(2+)-ions in solutions has been developed. Specially elaborated ion-sensitive membrane compositions based on valinomycin and calcium ionophore calcium bis[4-(1,1,3,3-tetramethylbutyl)phenyl] phosphate (t-HDOPP-Ca) were deposited as separate layers on a silanized surface of the Si/SiO(2)/Si(3)N(4)-transducer. The proposed multi-sensor exhibits theoretical sensitivities and the detection limits of the sensor were found to be 2 x 10(-6) mol l(-1) for K(+) and 5 x 10(-6) mol l(-1) for Ca(2+).

The light-addressable potentiometric sensor for multi-ion sensing and imaging.

The light-addressable potentiometric sensor (LAPS) is a semiconductor-based chemical sensor with an electrolyte-insulator-semiconductor structure. The LAPS can have many measuring points integrated on the sensing surface, which are individually accessed by a light beam. By modifying the measuring points with different materials, a single sensor plate can be used as a multi-analyte sensor.