A sandwich-type electrochemiluminescence biosensor based on Ni(HAB)/Au@ZnNiAl-LDH/Ru@MIL-53(Al)-NH for ultra-sensitive detection of microRNA-155.

A novel electrochemiluminescence (ECL) biosensor was developed for the ultrasensitive detection of miRNA-155, based on the synergistic combination of multifunctional nanomaterials. The biosensor employed a conductive metal-organic framework (MOF), Ni(HAB) (HAB = hexaaminobenzene), as the substrate material. The unique π-electron conjugated structure of Ni(HAB) endowed the biosensor with excellent electron transport properties, significantly enhancing its sensitivity.

[Investigation and analysis of oral health status of children with autism and their parents' cognition].

Purpose: To understand the cognitive level of parents of children with autism towards their oral health behaviors and oral health care, and to provide assistance in developing better oral health plans for children with autism.

Methods: Totally 117 children and parents with autism who visited our hospital from January to December 2018 were selected as the experimental group,while 121 non-autistic children during the same period were selected as the control group, the children's oral hygiene was checked. Questionnaire survey was conducted on the oral health behaviors of pediatric patients, including daily brushing frequency, use of toothpaste, assistance from parents in brushing teeth, and frequency of snacking.

A study on maglev force and vibration attenuation characteristics of quasi-zero stiffness cruciform maglev isolator.

This paper aims to study the maglev force and vibration attenuation characteristics of quasi-zero stiffness cruciform maglev isolators (CMIs). The maglev force and stiffness of CMIs were analytically computed based on equivalent charge theory, and the transfer function of the system was conducted. The effects of magnet geometry parameters and air gap on the maglev force, stiffness, and vibration transmission characteristics of the CMI system were revealed through parametric analyses.

The Safety and Effectiveness of Telemedicine for Cancer-Related Colostomy Care in the Early Stage of Discharge: A Prospective, Randomized, Single-Center Study.

Background: There has been an exponential growth in the use of telemedicine services to provide clinical care. However, the safety and effectiveness of telemedicine in cancer-related colostomy care during the early stages of discharge remain unclear. This study aimed to support that the safety and effectiveness of telemedicine in cancer-related colostomy care were not inferior to those of outpatient care.

Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.

Background: This study aimed to develop a novel nomogram that can accurately estimate platinum resistance to enhance precision medicine in epithelial ovarian cancer(EOC).

Methods: EOC patients who received primary therapy at the General Hospital of Ningxia Medical University between January 31, 2019, and June 30, 2021 were included. The LASSO analysis was utilized to screen the variables which contained clinical features and platinum-resistance gene immunohistochemistry scores.

U0126 and BAY11-7082 Inhibit the Progression of Endometriosis in a Rat Model by Suppressing the MEK/ERK/NF-κB Pathway.

Endometriosis is an aggressive disease. It is the main cause of chronic pelvic pain, dysmenorrhea, and infertility, affecting the well-being of women. This study aimed to explore the role of U0126 and BAY11-7082 in endometriosis (EMs) treatment in rats by targeting the MEK/ERK/NF-κB pathway.

The role of Connexin26 regulated by MiR-2114-3p in the pathogenesis of ovarian cancer.

Objectives: The purpose of our research was to determine the expression of Cx26 and miR-2114-3p, and their effects on proliferation, migration, and invasion in ovarian cancer and their mechanisms.

Materials And Methods: Transcriptome sequencing was performed and differentially expressed Cx26 was screened. The mRNA and protein levels of Cx26 in EOC and normal ovarian tissues were verified.

Value of the risk of ovarian malignancy algorithm index in predicting the recurrence of epithelial ovarian cancer.

This study aimed to assess the predictive and diagnostic value of the risk of ovarian malignancy algorithm (ROMA) index for epithelial ovarian cancer (EOC) recurrence. The clinical features and follow-up data of 159 EOC cases were studied. The ROMA index was calculated by serum CA125 and HE4 levels with menopausal status.

Knockdown of ribosomal protein S6 suppresses proliferation, migration, and invasion in epithelial ovarian cancer.

Background: Ovarian cancer typically is diagnosed late because insensitivity and lack of specificity of current biomarkers prior to its clinical detection. Ribosomal protein S6 (RPS6) is a ribosomal protein involved in the ribosomal 40S subunit, but its biological role in epithelial ovarian cancer (EOC) is still unknown.

Results: RPS6 was elevated in EOC compared to normal ovarian tissues and adenomas.

Research on the Recognition Performance of Bionic Sensors Based on Active Electrolocation for Different Materials.

Underwater object identification by optical sensors is usually difficult in turbid or dark environments. The objective of this paper was to identify different underwater materials using active electrolocation technology. We proposed a bionic sensor inspired by the weakly electric fish.

Consistency of postoperative pain assessments between nurses and patients undergoing enhanced recovery after gynaecological surgery.

Aims And Objectives: To explore the consistency of pain intensity and pain location assessed by nurses and patients in gynaecology undergoing enhanced recovery after surgery pathway.

Background: Several studies have shown that clinical nurses' assessment of patients' pain is not always accurate. Little is known about the accuracy of nurses' pain assessments for gynaecological patients.

The combined expressions of B7H4 and ACOT4 in cancer-associated fibroblasts are related to poor prognosis in patients with gastric carcinoma.

B7H4 is a member of the B7 family, which is expressed on antigen-presenting cells (APCs) and which negatively regulates the immune response of T cells through the inhibition of their proliferation, cytokine production, and cell cycle progression. Acyl-CoA thioesterase 4 (ACOT4) is an isoform of the ACOTs family that catalyzes the hydrolysis of fatty acyl-CoA to CoA-SH and free fatty acids. An abnormal metabolism of lipids and fatty acids is observed during tumor progression.

Research on Finite Element Model Modification of Carbon Fiber Reinforced Plastic (CFRP) Laminated Structures Based on Correlation Analysis and an Approximate Model.

Carbon fiber reinforced plastic (CFRP) laminated structures have been widely used in modern engineering due to their excellent material properties, especially in the aerospace and shipping industries. This requires a high-accuracy finite element model of CFRP laminated structures. However, it is difficult to master the mechanical properties of CFRP structures comprehensively and accurately due to influences from multiple aspects, such as dispersion of material properties, uncertainty of manufacturing technologies, etc.

Buformin increases radiosensitivity in cervical cancer cells via cell-cycle arrest and delayed DNA-damage repair.

Our idea originated in the thought of discovering new effects of old drugs. Although this study is a basic research, it is very close to clinical treatment. Flow cytometry and immunofluorescence were used to verify that buformin increases radiosensitivity.

Otologic Disease Following Palatoplasty In International Cleft Palate Cohort.

Objective: Study the prevalence of otologic disease in a pediatric post-palatoplasty population with no prior ear tube placement in resource-deprived countries and assess patient characteristics associated with these abnormal results.

Design: Retrospective data review.

Participants: Ecuadorian and Chinese children identified during humanitarian cleft lip and palate repair trips with cleft palates undergoing palatoplasty from 2007 to 2010.

Serine protease isoforms in Gloydius intermedius venom: Full sequences, molecular phylogeny and evolutionary implications.

Unlabelled: Nine distinct venom serine proteases (vSPs) of Gloydius intermedius were studied by transcriptomic, sub-proteomic and phylogenetic analyses. Their complete amino acid sequences were deduced after Expression Sequence Tag (EST) analyses followed by cDNA cloning and sequencing. These vSPs appear to be paralogs and contain the catalytic triads and 1-4 potential N-glycosylation sites.

Palatal fistula risk after primary palatoplasty: a retrospective comparison of humanitarian operations and tertiary hospitals.

Background: Humanitarian surgical organisations provide cleft palate repair for patients without access to surgical care. Despite decades of experience, very little research has assessed the outcomes of these trips. This study investigates the fistula rate in patients from two cohorts in rural China and one in the USA.

Transcriptome and proteome of the highly neurotoxic venom of Gloydius intermedius.

The venomics of Gloydius intermedius were investigated using expressed sequence tags (ESTs) analyses, 2D gel-electrophoresis combined with MALDI-TOF/TOF, and LC-MS/MS. A total of 1920 ESTs from the venom gland cDNA library were sequenced; 74% of them belonged to toxin-families. The four most abundant families among the toxin transcripts were: serine protease (SP, 36.

Association of tea consumption and the risk of oral cancer: a meta-analysis.

Objectives: Epidemiological studies evaluating the association of tea consumption and the risk of oral cancer risk have produced inconsistent results. Thus, we conducted a meta-analysis to assess the relationship between tea consumption and oral cancer risk.

Methods: Pertinent studies were identified by a search in PubMed, Web of Knowledge and Wan Fang Med Online.