Bidirectional Mendelian randomization and colocalization analysis of gut microbiota on lipid profile.

The gut microbiota plays a crucial role in human health, but its impact on lipid metabolism remains unclear. Understanding the causal relationship between gut bacteria and lipid profiles is essential for developing strategies to prevent and treat dyslipidemia and cardiovascular diseases. This study aimed to assess this relationship using two-sample Mendelian randomization (MR).

Metabolic Syndrome and Efficacy of Remote Ischemic Postconditioning in Acute Moderate Ischemic Stroke: A Post Hoc Analysis of the RICAMIS Trial.

Background: Metabolic syndrome (METS) is associated with poor outcomes after acute ischemic stroke. This study aimed to investigate the relationship between METS and efficacy of remote ischemic postconditioning (RIPostC) in acute moderate ischemic stroke using the database of the RICAMIS (Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke) trial.

Methods And Results: In the RICAMIS trial, eligible participants were patients with acute moderate ischemic stroke within 48 hours of onset who did not receive reperfusion treatment.

Associations between exposure to brominated flame retardants and hyperlipidemia risk in U.S. Adults.

Background: Environmental exposure to toxic brominated flame retardants (BFRs) has been confirmed to have detrimental effects on human health. The impact of serum BFRs on hyperlipidemia risk has not been sufficiently examined. Our objective is to identify both the individual and combined effects of serum BFRs on hyperlipidemia and to further investigate the most influential chemicals.

A novel crosslinked chitosan material modified by quaternary ammonium group for efficient adsorption of bromide ions from wastewater.

Recovering bromide ions from wastewater can not only alleviate the shortage of bromine resources but also solve the problem of bromine pollution. However, there is no efficient method for selective extraction of bromide ions from bromine-containing wastewater up to now. In this paper, chitosan was acidified into a gel to extend its molecular chain, modified by quaternary ammonium salt functional groups, and then crosslinked to obtain a new adsorption material.

Edaravone dexborneol for ischemic stroke with sufficient recanalization after thrombectomy: a randomized phase II trial.

phase II, randomized, double blinded, multi-center study aims to explore whether intravenous edaravone dexborneol (ED) could improve clinical outcomes in patients with anterior circulation stroke with successful endovascular reperfusion (ClinicalTrials.gov: NCT04667637 Eligible patients were randomly (1:1) assigned into ED, which received intravenous ED (37.5 mg, 2/day, for 12 days) or control group, which received placebo.

Tandem Synergistic Catalysis on Cu-Pd/BiTiO Nanorods Promoting Highly Selective Photoconversion of CO to Ethyl Alcohol.

The production of high-energy-density liquid fuels through the photoconversion of CO offers a highly efficient method for storing sustainable solar energy for future use. BiTiO (BTO) nanorods loaded with Cu-Pd nanoalloys were designed for the highly selective photoreduction of CO to ethyl alcohol, using HO as the proton source. A tandem synergistic catalysis mechanism was proposed for this CO photoconversion process.

Single-Atom Saturation: A Fundamental Principle for Single-Atom-Site Catalyst Design.

Single-atom alloys (SAAs), with twin advantages of alloys and single-atom catalysts, have emerged as an innovative class of electrocatalysts. This uniqueness is expected to achieve unattainable catalytic performance but simultaneously gives rise to the absence of guidelines for designing desired SAAs. Herein, we proposed a fundamental principle, single-atom saturation (), to quantify the binding strength of different intermediates on SAAs, enabling the rapid and qualitative evaluation of the catalytic activity across various reactions.

Triple-incision treatment of the posterior condylar triad in the lateral prone position.

Background: Posterior tibial plateau bicondylar fracture combined with anterior cruciate ligament injury, also known as the "Posterior Condylar Triad", is a regular combination injury. The traditional surgical strategy involves first fixing the posterior condyle in the prone position and then treating the anterior cruciate ligament avulsion injury after the patient turns over. This surgical strategy is cumbersome, requires multiple surgical preparations, prolongs the surgical time, and increases the patient's risk.

Social participation and exposure to tuberculosis education: a cross-sectional study of older (≥ 60 years) domestic migrants in China.

Background: Older domestic migrants have a higher risk of infection of tuberculosis or reactivation of latent tuberculosis than other populations in China. This study aimed to assess the exposure level of older domestic migrants to tuberculosis education and its association with social participation.

Methods: Data were extracted from the 2017 China Migrants Dynamic Survey (CMDS).

ADAMTS13 attenuates renal fibrosis by suppressing thrombospondin 1 mediated TGF-β1/Smad3 activation.

Renal fibrosis is a common pathologic pathway for the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD). Its mechanisms are unclear and it lacks effective therapy. Thrombospondin 1 (TSP1) mediated transforming growth factor-β1 (TGF-β1) activation was confirmed to promote renal fibrosis.

Treatment of early hypertensive renal damage with Quanduzhong capsules: two case reports.

Background: Hypertensive nephropathy is increasingly prevalent and a leading cause of end-stage renal disease. Current treatment strategies for hypertensive nephropathy focus on blood pressure control and reducing urinary albumin. However, the use of angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB) medications carries risks, including a potential decrease in glomerular filtration rate (GFR).

A Pyridine Amine Extractant for Separation of La and Ce in HNO Solution.

The separation of lanthanum and cerium is of great significance for improving the material properties and promoting scientific and technological progress. In this paper, a pyridine amine extractant, (1,2)-1,2-bis((5-methylpyridin-2-yl)methyl)cyclohexane-1,2-biamine (cis-BMPyMChBA), was designed for the separation of lanthanum and cerium. The aim is to use this extractant to catalyze the oxidation of tri- to tetravalent cerium and to increase the separation efficiency between lanthanum and cerium.

Gas-phase fractionation DDA promotes in-depth DIA phosphoproteome analysis.

Data-independent acquisition (DIA) is a promising method for quantitative proteomics. Library-based DIA database searching against project-specific data-dependent acquisition (DDA) spectral libraries is the gold standard. These libraries are constructed using material-consuming pre-fractionation two dimensional DDA analysis.

Cognitive trajectories and their relationships with education and diets among older adults: a network-based 10-year cohort study.

Objectives: Few studies have examined the underlying mechanisms of education, diets, and cognitive function in older adults. This study analyses the relationship between cognitive trajectories, education, and different dietary patterns in older adults from a network perspective, and further explores their longitudinal associations and mediation effects.

Methods: Data on cognitive trajectories were derived from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) between 2008 and 2018.

Revising the coal mining CH emission factor based on multiple inventories and atmospheric inversion approach at one of the world's largest coal production areas: Shanxi province, China.

Methane (CH) emissions from the coal industry represent a substantial portion of anthropogenic CH emissions from energy-related activities. China ranks as the world's largest coal producer, where Shanxi Province is one of its major coal production regions and accounts for 20.7 % of the national total coal production.

Organ-specific immune-related adverse events and prognosis in cancer patients receiving immune checkpoint inhibitors.

Background: Patients who developed immune-related adverse events (irAEs) could benefit more from treatment with immune checkpoint inhibitors (ICIs) than those who did not develop irAEs. This study was designed to assess whether the occurrence of irAEs or their characteristics are correlated with survival in advanced patients treated with ICIs.

Methods: This retrospective cohort study enrolled a panel of cancer patients who received ICIs at a single institute.

The impact of the COVID-19 pandemic on mental coping and emergency ability of public health emergency in COVID-19 department healthcare workers in ICU nurses of Beijing in China.

Background: The COVID-19 pandemic has brought various opportunities and challenges to critical care nurses, whose emergency abilities in caring for critically ill patients are related to their safety, clinical effectiveness, and improved prognosis. Currently, there is a lack of research on the actual situation and influencing factors of ICU nurses' emergency ability during the COVID-19 pandemic. Although empirical observations from different departments can provide valuable basis for the health system to formulate preventive measures, efficient training programs and future public emergencies.

Early Neurologic Deterioration and Efficacy of Dual Antiplatelet in Anterior Versus Posterior Circulation Stroke.

Background: Anterior circulation stroke (ACS) differs from posterior circulation stroke (PCS) in several aspects. We hypothesize that the risk of early neurologic deterioration (END) and its responses to clopidogrel plus aspirin versus aspirin alone may be different between stroke territories.

Methods And Results: This was a prespecified post hoc analysis of ATAMIS (Antiplatelet Therapy in Acute Mild to Moderate Ischemic Stroke) trial and included patients with definite infarct location who were classified into ACS and PCS according to stroke territory.

Intravenous tenecteplase bridging reperfusion ameliorates cerebral ischemia/reperfusion injury by improving microvascular circulation in rats.

Background: Endovascular thrombectomy (EVT) alone was not demonstrated to be noninferior to intravenous alteplase bridging EVT in acute large vessel occlusion stroke. Using the cerebral ischemia/reperfusion (I/R) injury model, intravenous tenecteplase (TNK) was administrated after ischemia, followed by reperfusion at various time points.

Objectives: To investigate whether intravenous TNK bridging EVT vs EVT alone could improve I/R injury, and this effect may be associated with the time from TNK to reperfusion.

Study of PEG-rhG-CSF for the prevention of neutropenia in concurrent chemoradiotherapy for nasopharyngeal carcinoma.

Background: To study the efficacy and safety of Polyethylene glycolated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in the prevention of neutropenia during concurrent chemoradiotherapy for nasopharyngeal carcinoma (NPC).

Methods: This is a single-center, prospective, randomized controlled study conducted from June 1, 2021, to October 31, 2022 on patients diagnosed with locally advanced NPC. Participants were divided into an experimental group and a control group.

Application of ChatGPT-assisted problem-based learning teaching method in clinical medical education.

Introduction: Artificial intelligence technology has a wide range of application prospects in the field of medical education. The aim of the study was to measure the effectiveness of ChatGPT-assisted problem-based learning (PBL) teaching for urology medical interns in comparison with traditional teaching.

Methods: A cohort of urology interns was randomly assigned to two groups; one underwent ChatGPT-assisted PBL teaching, while the other received traditional teaching over a period of two weeks.

The efficacy of remote ischemic conditioning for outcomes in ischemic stroke patients with or without prior stroke: A post hoc analysis of the RICAMIS trial.

Background And Purpose: To investigate the impact of a history of ischemic stroke or transient ischemic attack (TIA) on the effectiveness of remote ischemic conditioning (RIC) for outcomes in acute ischemic stroke patients.

Methods: We conducted a post hoc analysis of the Remote Ischaemic Conditioning for Acute Moderate Ischaemic Stroke (RICAMIS) trial. Patients in RICAMIS were categorized into two groups according to a history of stroke.

Comparative evaluation of high-flow nasal cannula (HFNC) and conventional oxygen therapy (COT) in infants after non-cardiac surgery: Study protocol of a randomized controlled trial.

Background: Literature regarding the advantages of HFNC in infants for ensuring oxygen supply after non-cardiac surgery is insufficient. The purpose of our study is to compare COT vs. HFNC on postoperative outcomes in infants undergoing non-cardiac surgery.

Immunomodulatory Effects of SPHK1 and Its Interaction with TFAP2A in Yellow Drum ().

Sphingosine kinases (SPHKs) are essential enzymes that catalyze the phosphorylation of sphingosine to produce sphingosine-1-phosphate (S1P), which plays pivotal roles in inflammation and immune regulation. In this study, genome-wide association analysis (GWAS) identified the gene as closely associated with the resistance of yellow drum () to . Structural prediction showed that YDSPHK1 contains a typical diacylglycerol kinase catalytic (DAGKc) domain (154-291 aa).

Dissociated response and treatment outcome with immune checkpoint blockade in advanced cancer.

Immune-related dissociated response (DR) has been recently recognized and have become a subject of ongoing interest. The purpose of the present study was to evaluate the frequency, treatment outcome, and predictors of DR in cancer patients with immune checkpoint inhibitors. We retrospectively collected clinicopathological data from a cohort of patients with cancer who received PD-1/PD-L1 inhibitor-based monotherapy or combination therapy at a single institution (developing cohort).