Publications by authors named "Yu Canqing"
Associations of adiposity with risks of oesophageal squamous cell carcinoma (ESCC) and non-cardia stomach cancer, both prevalent in China, are still inconclusive. While adiposity is an established risk factor for colorectal cancer, the relevance of fat-free mass and early-adulthood adiposity remains to be explored. The prospective China Kadoorie Biobank study included 0.
View Article and Find Full Text PDFBackground: Risk prediction models can identify individuals at high risk of chronic liver disease (CLD), but there is limited evidence on the performance of various models in diverse populations. We aimed to systematically review CLD prediction models, meta-analyze their performance, and externally validate them in 0.5 million Chinese adults in the China Kadoorie Biobank (CKB).
View Article and Find Full Text PDFLittle is known about the population-based mismatch between phenotypic and genetic BMI (BMI-PGM) and its association with type 2 diabetes. We therefore used data from the China Kadoorie Biobank and UK Biobank and calculated BMI-PGM for each participant as the difference between the percentile for adjusted BMI at baseline and the percentile for adjusted polygenic risk score for BMI. Participants were categorized into discordantly low (BMI-PGM< the 1st quartile), concordant (the 1st quartile ≤BMI-PGM
Background: Little evidence is available on the long-term health effects of nitrogen dioxide (NO) in low-income and middle-income populations. We investigated the associations of long-term NO exposure with the incidence of a wide spectrum of disease outcomes, based on data from the China Kadoorie Biobank.
Methods: This prospective cohort study involved 512 724 Chinese adults aged 30-79 years recruited from ten areas of China during 2004-08.
Associations of Muscle-Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort Study.
J Cachexia Sarcopenia Muscle
February 2025
Article Synopsis
- - The study investigates the link between muscle mass, strength, quality, and respiratory diseases specifically in a Chinese population, using data from the China Kadoorie Biobank.
- - Researchers followed 17,510 participants over approximately 4.82 years and found that those with low grip strength and poor arm muscle quality had significantly higher risks of developing respiratory diseases, with hazard ratios of 1.31 and 1.25, respectively.
- - The results suggest that low grip strength and arm muscle quality are more predictive of respiratory disease risk compared to overall muscle mass, emphasizing their importance as health indicators.
Plasma proteomics could enhance risk prediction for multiple diseases beyond conventional risk factors or polygenic scores (PS). To assess utility of proteomics for risk prediction of ischemic heart disease (IHD) compared with conventional risk factors and PS in Chinese and European populations. A nested case-cohort study measured plasma levels of 2923 proteins using Olink Explore panel in ~ 4000 Chinese adults (1976 incident IHD cases and 2001 sub-cohort controls).
View Article and Find Full Text PDFSeveral crucial acceleration periods exist during aging process. Epigenetic clocks, serving as indicators of aging, are influenced by genetic factors. Investigating how the genetic contributions on these clocks change with age may provide novel insights into the aging process.
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- The study investigated the impact of meal-replacement (MR) drinking on the risk of dying from various causes, including general mortality, cardiovascular and cerebrovascular diseases, and cancer, using data from 6770 adults aged 20 and older.
- Results showed that individuals who drank MR daily or weekly had a significantly higher risk of all-cause mortality compared to those who seldom drank it, with effects being particularly stronger in females.
- The findings suggest that regularly consuming meal replacements could potentially contribute to increased mortality risk, highlighting the need for caution in their use.
Article Synopsis
- This study explored how consuming two types of preserved vegetables in China (salted and sour pickled) relates to the risk of gastrointestinal cancers, including oesophageal, stomach, and colorectal cancers.
- The research analyzed data from over 510,000 adults, assessing their vegetable intake and monitoring cancer development over 14 years.
- Results indicated that salted vegetable consumption is linked to a higher risk of stomach cancer, while sour pickled vegetables are associated with an increased risk of oesophageal cancer, suggesting that reducing preserved vegetable intake may help lower the risk of these cancers.
Article Synopsis
- The prevalence of COPD (Chronic Obstructive Pulmonary Disease) in Chinese individuals over 50 is significantly higher than in younger adults, but the specific risk factors for this older age group were previously unclear.
- Recent findings show that the COPD prevalence is 12.8% for males and 5.7% for females in this age group, with identified risk factors including cigarette smoking, family history of respiratory issues, and childhood respiratory problems.
- These insights can aid healthcare providers and the public in recognizing those at greater risk for COPD, allowing for more effective prevention and intervention strategies.
What Is Already Known About This Topic?: China has the world's most significant public health and economic burden of chronic respiratory disease. However, the association between preserved ratio impaired spirometry (PRISm) and mortality risk is unknown.
What Is Added By This Report?: The PRISm group exhibited a 37% higher risk of all-cause mortality than the normal group, and the risks of death from cardiovascular diseases, neoplasms, respiratory diseases, and infectious and parasitic diseases were also increased in PRISm.
Article Synopsis
- Recent guidelines suggest that individuals with prehypertension (130/80 to 139/89 mm Hg) should consider antihypertensive treatment; this study assesses the cost-effectiveness of three interventions: salt substitution, antihypertensive drugs, and their combination in Chinese adults.
- A Markov cohort model was used to estimate the impact of these interventions on cardiovascular disease events, costs, and quality-adjusted life years (QALYs), utilizing data from the China Kadoorie Biobank.
- The findings indicate that salt substitution is the most cost-effective strategy for prehypertensive individuals starting at age 40, while a combination intervention is best for those at high cardiovascular risk; beginning these interventions at younger ages can lead to more
Background: Sleep can function as a potential modifiable risk factor in the control and prevention of stroke. Geography significantly influences sleep patterns. The association of sleep with stroke in population of Southwest China has not so far been investigated.
View Article and Find Full Text PDFAdiposity is an established risk factor for multiple diseases, but the causal relationships of different adiposity types with circulating protein biomarkers have not been systematically investigated. We examine the causal associations of general and central adiposity with 2923 plasma proteins among 3977 Chinese adults (mean BMI = 23.9 kg/m²).
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- The study investigates the link between mosaic loss of chromosome Y (mLOY) and the risk of lung diseases in older men, using data from over 260,000 participants in two major biobanks.
- Findings indicate that individuals with mLOY have a higher risk of developing various lung diseases, including chronic obstructive pulmonary disease (COPD), lung cancer, and idiopathic pulmonary fibrosis (IPF).
- The research suggests that mLOY may serve as a significant predictor for age-related lung diseases, particularly for current smokers, highlighting the importance of smoking cessation to reduce associated health risks.
Article Synopsis
- Non-optimal temperature significantly contributes to global disease burden, but most studies have focused on outdoor temperatures, potentially leading to misclassification of personal temperature exposure.
- The CKB-Air study analyzed temperature data from 477 participants across personal, household, and outdoor settings during summer and winter in China, recording around 88,000 person-hours of data.
- The study found strong correlations between personal and household temperatures in winter and significant predictors for personal temperature exposure, achieving good prediction accuracy, while identifying a U-shaped relationship between personal temperature exposure and heart rate.
[Epidemiological characteristics of hemorrhoids in a healthy physical examination population in China].
Beijing Da Xue Xue Bao Yi Xue Ban
October 2024
Article Synopsis
- The study aimed to analyze the distribution of hemorrhoids among adults undergoing physical exams in China, providing insights for better prevention and intervention strategies.
- A total of nearly 2.94 million adults were examined, revealing a significantly higher detection rate of hemorrhoids in women (43.7%) compared to men (17.7%), with specific age groups showing varying prevalence.
- Factors such as age, obesity, and hypertension were identified as influences on the likelihood of having hemorrhoids, suggesting the need for targeted awareness and screening initiatives.
Background: Observational studies have shown a controversial relationship between dietary fat intake and Alzheimer's disease, and the causal effects are unclear.
Aims: To assess the causal effects of total fat, saturated fat and polyunsaturated fat (PUF) intakes on the risk of Alzheimer's disease.
Method: A two-sample Mendelian randomisation analysis was performed using genome-wide association study summary statistics on different types of fat intake from UK Biobank ( = 51 413) and on late-onset Alzheimer's disease (LOAD; 4282 cases, = 307 112) and all forms of Alzheimer's disease (6281 cases, = 309 154) from the FinnGen consortium.
Article Synopsis
- Monitoring biochemical changes during pregnancy is crucial for the health of both mothers and babies, enabling early intervention for potential issues.
- A genetic analysis of over 20,000 Chinese women identified 410 trait-locus associations related to pregnancy, with many being newly discovered associations.
- The research highlighted important biological pathways involved in pregnancy, such as hormone regulation and immune response, furthering our understanding of how genetics influence pregnancy outcomes and maternal health.
Background: Higher body mass index (BMI) is associated with higher incidence of cardiovascular and some non-cardiovascular diseases (CVDs/non-CVDs). However, uncertainty remains about its associations with mortality, particularly at lower BMI levels.
Methods: The prospective China Kadoorie Biobank recruited >512 000 adults aged 30-79 years in 2004-08 and genotyped a random subset of 76 000 participants.
Article Synopsis
- The study explores the link between autosomal mosaic chromosomal alterations (mCAs) and bladder cancer using data from nearly 100,000 participants in the China Kadoorie Biobank who were cancer-free at the start.
- Researchers found that individuals with autosomal mCAs had a significantly higher risk of developing bladder cancer, with the highest risk associated with mosaic loss events.
- The results also indicated that lower levels of physical activity increased the cancer risk for those with mCAs, suggesting that physical activity might be a beneficial factor for mCAs carriers to reduce their risk.
Article Synopsis
- The study investigated if phenotypic age mediates how a healthy lifestyle impacts mortality rates.
- Participants included adults from a national health survey, where data on their phenotypic age and Life's Essential 8 (LE8) scores were analyzed for mortality links.
- Results showed that older phenotypic age increased mortality risk, while a healthy lifestyle (high LE8 scores) corresponded to a younger phenotypic age, with PhenoAge mediating significant portions of the mortality risk associated with LE8 adherence.
- The study concluded that following LE8 guidelines can slow down phenotypic aging and reduce mortality risk.
Background: Alterations in lipid metabolism and DNA methylation are 2 hallmarks of aging. Connecting metabolomic, epigenomic, and aging outcomes help unravel the complex mechanisms underlying aging. We aimed to assess whether DNA methylation clocks mediate the association of circulating metabolites with incident atherosclerotic cardiovascular disease (ASCVD) and frailty.
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- Dyslipidemia, a key factor in global mortality, is linked to metabolic disorders and cardiometabolic diseases, which can be better understood through the study of blood lipids and metabolites.
- A study involving 437 twins and targeted metabolomics identified 44, 1, and 31 metabolites related to triglycerides, total cholesterol, and HDL-C, respectively, many derived from gut microbiota.
- Causal inference and mediation analyses revealed that triglycerides and HDL-C may influence a significant number of metabolites, emphasizing the role of gut microbiota in lipid metabolism and offering insights for personalized treatment of cardiometabolic conditions.