[Analysis of colonization rate and molecular characteristics of on tracheotomy wounds at early postoperational stage in neonates].

To analyze the colonization rate and molecular types of (SA) on the tracheotomy wounds of neonates at early postoperative stage in neonatal intensive care unit (NICU). This was a case series study. Patients who were admitted and underwent tracheotomy in NICU of Beijing Children's Hospital, Capital Medical University from January 1 2020 to December 31 2023 were enrolled.

[Analysis of perinatal factors for death or severe intraventricular hemorrhage within the first week of life in preterm infants with gestational age <32 weeks].

To analyze the incidence and perinatal factors of death or severe intraventricular hemorrhage (sIVH) within the first week of life in preterm infants with gestational age <32 weeks. Based on the online data platform of Sina-northern Neonatal Network (SNN), a case-control study was conducted using clinical data from 8 903 preterm infants with gestational age <32 weeks admitted to 35 neonatal intensive care units (NICU) between 2019 and 2023. Infants were classified by gestational age at birth into very preterm infants and extremely preterm infants.

Electric-Dipole Coupling Ion-Dipole Engineering Induced Rational Solvation-Desolvation Behavior for Constructing Stable Solid-State Lithium Metal Batteries.

Solid-state polymer electrolytes (SPEs) with high ionic conductivity, a wide voltage window, and an ultra-stability electrolyte/electrode interface are essential for practical applications of solid lithium-metal batteries but particularly challenging. The key to overcoming these long-term obstacles lies in the rational design of the Li+ solvation-desolvation behavior in SPEs. Herein, we propose an electric-dipole coupling ion-dipole strategy to modulate the Li+ solvation structure and enhance Li+ desolvation kinetics.

Asymmetric Structural Design in Cobaloxime-Integrated Covalent Organic Frameworks to Facilitate Photocatalytic Overall Water Splitting​.

Herein, we report a hydrogen-bonded supramolecular hybrid composed of a cobaloxime complex and a covalent organic framework (COF) that achieves photocatalytic overall water splitting. The designed COF features ternary units and dual linkages, which induce asymmetric linkers. Upon photoexcitation, this asymmetry facilitates directed electron transfer and spatially separated redox sites, resulting in a long-lived charge-separated state.

Reoperative Laparoscopic Liver Resection for Hepatolithiasis Patients With a History of Biliary Surgery: A Cohort Study.

Introduction: It is unclear whether laparoscopic hepatectomy for hepatolithiasis patients with a history of biliary surgery achieves favorable clinical outcomes. This study aimed to evaluate the safety and feasibility of reoperative laparoscopic hepatectomy (rLH).

Methods: Patients who underwent anatomical liver resection for hepatolithiasis between 2015 and 2022 were included in the study.

The Choice of Hip Arthroplasty: HRA or THA? Revealed by Meta-Analysis.

Background: Total hip arthroplasty (THA) is the gold standard for end-stage hip arthrosis, while hip resurfacing arthroplasty (HRA) is considered a more bone-conserving alternative. This meta-analysis aimed to compare the safety and clinical efficacy of HRA and THA.

Methods: The databases of PubMed, EMBASE, Cochrane Library, and CNKI were searched for RCTs comparing HRA and THA in treating hip arthrosis from database initiation to April 2024.

Composite synthetic protein hydrogel for inhibition of corneal fibrosis and treatment of corneal wounds.

Corneal fibrosis, a severe complication linked to ocular injuries and post-surgery, lacks effective treatment. Hydrogels are regarded as one of the most promising biomaterials, particularly in the context of corneal wound treatment, where they have attracted considerable attention. Synthetic protein hydrogels are of particular interest due to their biocompatibility, biodegradability, capacity to mitigate induced tissue inflammatory responses, and their editable and modular integrative properties.

High self-extinguishing and thermal insulating PA66 composites enhanced with flame-retardant cellulose nanocrystals.

Polyamide 66 (PA66), a globally attractive high-performance plastic, is hindered by its poor fire resistance, which triggers excessive smoke and dripping. In this work, we introduce a novel halogen-free, thermal insulating flame-retardant for PA66, modified by cellulose nanocrystals (CNCs) with 3-aminopropyltriethoxysilane (APTES) and phosphoric acid (PA) to form a spider web-like nano composite CNC/A/P, by improving the thermal stability and inhibiting the droplet phenomenon of PA66. This high self-extinguishing flame retardant owns a 56.

Micro/nanomotors in targeted drug delivery: Advances, challenges, and future directions.

The therapeutic efficacy of drugs is highly dependent on their successful delivery to the target site. However, achieving targeted drug delivery to diseased areas remains a significant challenge. Current drug delivery systems based on nanocarriers often suffer from inefficiencies due to their lack of intrinsic propulsion and active targeting capabilities.

Pentose Phosphate Recycling driven by Gli1 contributes to chemotherapy resistance in Cancer Cells.

The Hedgehog Signaling Pathway plays an important role in cancer development and chemotherapy resistance. However, whether the pathway functions depend on the metabolic reprogramming of cancer cells has not been well studied. In this study, we found that the expression level of Gli1, a key transcription factor downstream of the Hedgehog Signaling Pathway, is significantly increased in patients with pancreatic cancer resistant to gemcitabine neoadjuvant chemotherapy.

Andrograpalides A-N, structurally diverse ent-labdane diterpenoids with anti-inflammatory activities from the leaves of Andrographis paniculata.

Andrograpalides A-N (1-14), fourteen previously undescribed ent-labdane-type diterpenoids, together with a previously undescribed naturally occurring diterpenoid (15) and two known analogues (16-17), were isolated from the leaves of Andrographis paniculata. Their structures were unambiguously elucidated via extensive spectroscopic analysis, electronic circular dichroism analysis, and X-ray crystallographic studies. Structurally, compounds 1-8 and 16 are rare cases of 19-nor labdane-type diterpenoids with an unusual C carbon skeleton.

Effects of pharmacological inhibition of FABP4 during gestation and lactation on offspring neurodevelopment and behavior.

Fatty acid-binding protein 4 (FABP4), a key regulator of lipid metabolism and inflammation, has been implicated in neurodevelopmental disorders, including autism spectrum disorder (ASD). This study investigated the effects of FABP4 inhibition during gestation and lactation on offspring neurodevelopment using the selective FABP4 inhibitor BMS309403. Female mice received BMS309403 (15 mg/kg) via oral gavage from two weeks before mating to postnatal day 28 (P28).

Domain alignment method based on masked variational autoencoder for predicting patient anticancer drug response.

Predicting the patient's response to anticancer drugs is essential in personalized treatment plans. However, due to significant distribution differences between cell line data and patient data, models trained well on cell line data may perform poorly on patient anticancer drug response predictions. Some existing methods use transfer learning strategies to implement domain feature alignment between cell lines and patient data and leverage knowledge from cell lines to predict patient anticancer drug responses.

Rapid enrichment of anaerobic ammonia oxidation bacteria by combining low nitrogen strength with microbial viability.

The rapid enrichment of anaerobic ammonia oxidation (anammox) bacteria (AnAOB) is challenging owing to their slow growth rate. Substrate supply strategies influence the AnAOB yield and anammox performance. In this study, a feeding strategy for low nitrogen strength with constant substrate concentrations and a hydraulic retention time decreasing over a gradient was investigated in an up-flow sludge blanket reactor.

Vulnerability and psychosocial impacts of extreme weather events among young people in Australia.

Aims: There is growing awareness of the negative impact that extreme weather events (also known as climate disasters) have on psychological and social wellbeing. Adolescents are particularly vulnerable to the psychosocial impacts of these events, but research specific to this population is scant. This study examined the impact of exposure to extreme weather events on climate concerns, psychological distress, and social exclusion in a large nationwide sample of adolescents.

Modulating excitation of the mediodorsal thalamus rescues dysfunction after administration of MK-801 in rats.

The excitation/inhibition (E/I) balance in the prefrontal cortex (PFC) is a dynamic equilibrium maintained by the concerted efforts of excitatory glutamatergic neurons and inhibitory γ-aminobutyric acid neurons (INs). The medial dorsal nucleus (MD) of the thalamus provides abundant pyramidal glutamatergic neural (PNs) projections to the PFC and regulates the E/I balance within the PFC. In schizophrenia, an imbalance in the E/I ratio in the PFC, along with reduced thalamocortical connectivity, has been observed.

Bleaching effectiveness of hydrogen peroxide containing titanium dioxide: A systematic review and meta-analysis.

Objectives: This systematic review and meta-analysis aimed to evaluate the efficacy of incorporating titanium dioxide (TiO) into a hydrogen peroxide (HP) gel to increase bleaching effectiveness.

Data Sources: A comprehensive search was conducted in the PubMed, Web of Science, and Scopus databases through February 12, 2024.

Study Selection: The eligibility criteria included studies comparing the bleaching effectiveness of HP alone to HP with incorporated TiO.

Guanine and isoguanine promote axon regeneration of dorsal root ganglion neurons and survival of retinal ganglion cells after injury.

Neurological injuries usually lead to motor, sensory, or cognitive impairment, which urgently need the development of effective therapeutic strategies. An increasing number of studies have indicated that metabolites can serve as therapeutic drugs for treating diseases or repairing damaged tissues. Among them, purines and their derivatives have shown the neuroprotection effects in the nervous system and garnered significant focus in the field of pharmaceutical development.

Hydrothermal reduction and phase transformation of Fe(III) minerals induced by rice straw to improve the heterogeneous Fenton degradation of metolachlor.

Heterogeneous Fenton technology is effective in degrading residual pesticides in soil, but the reduction of Fe(III) in the mineral structure presents a bottleneck. This study combined rice straw with Schwertmannite (Sch), ferrihydrite (Fh), and magnetite (Mag) via a hydrothermal process to obtain iron oxides-hydrothermal carbon composites (Sch@HTC, Fh@HTC, and Mag@HTC). Poor-crystallized Sch and Fh, which were more capable of accepting electrons compared to well-crystallized Mag, exhibited obvious phase transformation to highly active Fe(II)-mineral (humboldtine) via the combination of oxalic acid, an intermediate product, with reduced Fe(II), while Mag was hard to achieve.

Combined exposure of sleep deprivation and environmental particulate matter drives aging in multiple systems.

Sleep disturbance accelerates aging, with accompanying exposure to air pollution. However, most studies ignore the combined exposure. This study aimed to investigate the combined effects of sleep deprivation and PM exposure on multi-system aging and to explore the damage mechanisms.

A scoping review on the current state of sex- and gender-based analysis (SGBA) in standing balance research.

Background: Understanding sex and gender differences in standing balance is challenged by varied use of terminology and definitions. In addition, the use of sex- and gender-based analyses (SGBA) in standing balance research is unknown. This scoping review examined the frequency and type of SGBA, and the use of sex- and gender-based terminology in standing balance research published in the year 2020.

Promoting uniform distribution of zinc ions and stabilizing zinc anode by highly entangled zwitterionic hydrogels.

The application of aqueous zinc metal batteries is impeded by dendrite growth and rampant side reaction. Herein, a highly entangled zwitterionic hydrogel of l-carnitine/polyacrylamide is proposed for constructing the highly entangled polyacrylamide network that could form a high-speed channel for ion transport during charging and discharging processes. The interconnected polymer structure promotes uniform distribution of Zn, thereby effectively inhibiting dendrite formation.