Inherited Genetic Susceptibility to Nonimmunosuppressed Epstein-Barr Virus-associated T/NK-cell Lymphoproliferative Diseases in Chinese Patients.

Epstein-Barr virus (EBV) T/NK-cell lymphoproliferative diseases are characterized by clonal expansion of EBV-infected T or NK cells, including chronic active EBV infection of T/NK-cell type (CAEBVT/NK), EBV-associated hemophagocytic lymphohistiocytosis (EBVHLH), extranodal NK/T-cell lymphoma of nasal type (ENKTL), and aggressive NK-cell leukemia (ANKL). However, the role of inherited genetic variants to EBVT/NK-LPDs susceptibility is still unknown. A total of 171 nonimmunosuppressed patients with EBVT/NK-LPDs and 104 healthy donors were retrospectively collected and a targeted sequencing study covering 15 genes associated with lymphocyte cytotoxicity was performed.

Novel bioinformatic classification system for genetic signatures identification in diffuse large B-cell lymphoma.

Background: Diffuse large B-cell lymphoma (DLBCL) is a spectrum of disease comprising more than 30% of non-Hodgkin lymphomas. Although studies have identified several molecular subgroups, the heterogeneous genetic background of DLBCL remains ambiguous. In this study we aimed to develop a novel approach and to provide a distinctive classification system to unravel its molecular features.

[Threshold Flux and Membrane Fouling Analysis of the Hybrid Pre-ozonation and CNTs Membrane Modification Process].

Polyvinylidene fluoride (PVDF) hollow fiber ultrafiltration membranes were modified with carbon nanotubes (CNT). Hybrid pre-ozonation and CNT modification were investigated by experimentally manipulating the ozonation process, threshold flux, and membrane fouling. The results showed that the threshold fluxes of the unmodified membrane and hybrid process were 45 L·(m·h) and 81 L·(m·h), respectively.

[Effect of Hybrid Process of Pre-ozonation and CNT Modification on Hollow Fiber Membrane Fouling Control].

Polyvinylidene fluoride (PVDF) hollow fiber ultrafiltration membranes were modified with carbon nanotube (CNT). Combined with the ozonation process, the effect of the hybrid pre-ozonation and CNT modification on fouling alleviation was investigated. The impacts of CNT loading mass and ozone dosage on the variation of flux and antifouling ability of the membrane modules were evaluated.

[Effect of PVDF Hollow Fiber Ultrafiltration Membranes Modification with Carbonnanotube on Membrane Fouling Control During Ultrafiltration of Sewage Effluent].

The modification of hollow fiber ultrafiltration membranes with carbon nanotube (CNTs) on fouling control was investigated.Considering the antifouling ability of the CNT-modified membranes and the stability of CNTs layer,several factors were analyzed and evaluated,including the concentration of ethanol-dispersion,the diameter of CNTs,and the loading mass of CNTs.Besides,DOC,UV,and fluorescence characteristics of the permeate from the CNT-modified membrane were analyzed.