Publications by authors named "Yssi L Entzie"
Introduction: Maternal nutrition during pregnancy critically influences offspring development and immune function. One-carbon metabolites (OCM) are epigenetic modifiers that may modulate antimicrobial peptide (AMP) expression, which is vital for innate immunity. This study investigated the effects of maternal nutrient restriction and OCM supplementation on mRNA expression of AMP in fetal and maternal lung, mammary gland, and small intestine of beef cattle.
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- * The study examined how nutrient restriction and OCM supplementation affect fetal liver metabolomics in beef heifers, with different dietary patterns over a 63-day gestation period.
- * Findings revealed that restricted diets decreased metabolite levels linked to amino acid and energy metabolism, while OCM supplementation enhanced metabolite abundance important for fetal growth and health.
One-carbon metabolites (OCM) are metabolites and cofactors which include folate, vitamin B12, methionine, and choline that support methylation reactions. The objectives of this study were to investigate the effects of moderate changes in maternal body weight gain in combination with OCM supplementation during the first 63 d of gestation in beef cattle on (1) B12 and folate concentrations in maternal serum (2) folate cycle intermediates in maternal and fetal liver, allantoic fluid (ALF), and amniotic fluid (AMF) and (3) metabolites involved in one-carbon metabolism and related metabolic pathways in maternal and fetal liver. Heifers were either intake restricted (RES) and fed to lose 0.
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- The study examined how nutrient restriction and one-carbon metabolite (OCM) supplementation affect fetal small intestine development in crossbred Angus beef heifers during early gestation.
- Heifers were divided into four groups based on their feeding regimen: a control group with normal intake and an OCM group, versus a restricted intake group with and without OCM.
- Results showed that while the nutritional intake had no significant effect on fetal small intestine weight, OCM supplementation led to reduced weight, increased capillary density, and decreased cell proliferation in the tissue of fetuses from restricted-fed heifers.