Publications by authors named "Yssel Mendoza-Mari"

Article Synopsis
  • Traumatic brain injury (TBI) is a major global health issue that leads to various long-term problems, including motor, cognitive, and emotional difficulties.
  • * The complexities of TBI's effects and the lack of effective treatments stem from limited understanding of the brain's cellular and molecular responses to injury.
  • * In a pilot study involving Yucatan miniswine, researchers conducted RNA sequencing to identify genes affected by TBI and explored how electromagnetic field treatment influenced gene expression in injured brain tissues.
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Article Synopsis
  • Idiopathic pulmonary fibrosis (IPF) is a serious lung disease characterized by long-term progression, leading to reduced lung function and eventually death; while treatments like pirfenidone and nintedanib exist, a lung transplant remains the only effective long-term solution.
  • Diabetes mellitus is identified as a risk factor for IPF, with both conditions sharing similar damaging mechanisms such as inflammation and oxidative stress.
  • The article explores the connection between IPF and diabetes, discussing molecular mediators and potential drug targets, emphasizing the need for early detection and multipronged therapeutic strategies to improve treatment outcomes for IPF patients.
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Traumatic brain injury (TBI) due to a direct blow or penetrating injury to the head damages the brain tissue and affects brain function. Primary and secondary damage to the brain tissue increases disability, morbidity, and mortality and costs millions of dollars in treatment. Injury to the brain tissue results in the activation of various inflammatory and repair pathways involving many cellular and molecular factors.

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Traumatic brain injury is a leading cause of disability and death worldwide and represents a high economic burden for families and national health systems. After mechanical impact to the head, the first stage of the damage comprising edema, physical damage, and cell loss gives rise to a second phase characterized by glial activation, increased oxidative stress and excitotoxicity, mitochondrial damage, and exacerbated neuroinflammatory state, among other molecular calamities. Inflammation strongly influences the molecular events involved in the pathogenesis of TBI.

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HeberNasvac, a therapeutic vaccine for chronic hepatitis B, is able to safely stimulate multiple Toll-like receptors, increasing antigen presentation and in a phase II clinical trial (Profira) in elderly volunteers who were household contacts of respiratory infection patients. Thus, a new indication as a postexposure prophylaxis or early therapy for respiratory infections has been proposed. In this study, we evaluated the expression of several interferon-stimulated genes (ISGs) after mucosal administration of HeberNasvac and compared this effect with the nasal delivery of interferon alpha 2b (Nasalferon).

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Article Synopsis
  • * The study involved using non-invasive sensors to measure EMF in Yucatan miniswine that underwent a simulated traumatic brain injury (TBI), followed by targeted EMF signal modulation using a specific frequency for stimulation over several days.
  • * Results showed notable differences in EMF patterns and activity before and after stimulation, revealing new frequencies post-injury that weren’t present before, indicating potential for EMF modulation in therapeutic applications for brain injuries.
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Cellular memory is a controversial concept representing the ability of cells to "write and memorize" stressful experiences via epigenetic operators. The progressive course of chronic, non-communicable diseases such as type 2 diabetes mellitus, cancer, and arteriosclerosis, is likely driven through an abnormal epigenetic reprogramming, fostering the hypothesis of a cellular pathologic memory. Accordingly, cultured diabetic and cancer patient-derived cells recall behavioral traits as when in the donor's organism irrespective to culture time and conditions.

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Article Synopsis
  • Diabetic foot ulcers (DFU) have high inflammation levels due to persistent high blood sugar and local infections, making healing difficult; epidermal growth factor (EGF) treatment has shown promise in promoting healing and reducing amputation risk.
  • The study focuses on the effect of EGF on fibroblasts taken from DFU, particularly how it counters inflammation induced by lipopolysaccharides (LPS) in a simulated hyperglycaemic environment.
  • Results indicate that EGF can reduce the inflammatory response in fibroblasts challenged by LPS, suggesting it may be beneficial for DFU treatment in real-life clinical scenarios.
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  • Lower-extremity arterial disease is a growing health issue that can result in amputations and increased mortality, but the underlying causes of vascular wall changes are not well understood.* -
  • Researchers hypothesized that a "vascular tissue memory" might be passed from humans to healthy animals through signaling molecules, leading to similar vascular issues like wall thickening in the recipient animals.* -
  • In experiments, injecting arteriosclerotic tissue into rats caused significant changes in their vascular structure within days, suggesting these changes are driven by factors from the human tissue, opening up new avenues for studying atherosclerosis.*
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Introduction: More than 180 million people have been infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and more than 4 million coronavirus disease-2019 (COVID-19) patients have died in 1.5 years of the pandemic. A novel therapeutic vaccine (NASVAC) has shown to be safe and to have immunomodulating and antiviral properties against chronic hepatitis B (CHB).

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Background: Diabetic foot ulcers are a common diabetic complication leading to alarming figures of amputation, disability, and early mortality. The diabetic glucooxidative environment impairs the healing response, promoting the onset of a 'wound chronicity phenotype'. In 50% of ulcers, these non-healing wounds act as an open door for developing infections, a process facilitated by diabetic patients' dysimmunity.

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Article Synopsis
  • Lower limb ulcers in type-2 diabetes (T2DM) patients can lead to amputations and decreased survival rates.
  • The study explores how T2DM tissue can transfer impaired healing traits to healthy rats, mimicking diabetic wound characteristics.
  • Findings suggest that certain factors in diabetic tissues may contribute to healing problems and could have future implications for diabetes treatment strategies.
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  • Diabetes is rapidly increasing, leading to serious complications like lower limb ulcers and amputations due to impaired skin cell healing and resilience.
  • The condition creates a "senescent cells society," where aging and dysfunctional cells hinder the healing process, driven by factors like hyperglycemia and oxidative stress.
  • Effective treatment may involve targeting these senescent cells and their harmful secretions to improve healing outcomes for diabetic ulcers and prevent chronic wound development.
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Lower-extremity diabetic ulcers are responsible for 80% of annual worldwide nontraumatic amputations. Epidermal growth factor (EGF) reduction is one of the molecular pillars of diabetic ulcer chronicity, thus EGF administration may be considered a type of replacement therapy. Topical EGF ad-ministration to improve and speed wound healing began in 1989 on burn patients as part of an acute-healing therapy.

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The insulin signaling pathway plays a pivotal role in glucose metabolism and metabolic homeostasis. Disruption of this pathway is commonly seen in critical illness such as following severe burn injuries where homeostatic control is lost, leading to "insulin resistance" with poor blood glucose control. The aberrant signaling pathways involved in insulin resistance following burn injury include increases in hyperglycemic stress hormones, pro-inflammatory cytokines and free radical production.

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Diabetic foot ulcer is one of the most frightened diabetic complications leading to amputation disability and early mortality. Diabetic wounds exhibit a complex networking of inflammatory cytokines, local proteases, and reactive oxygen and nitrogen species as a pathogenic polymicrobial biofilm, overall contributing to wound chronification and host homeostasis imbalance. Intralesional infiltration of epidermal growth factor (EGF) has emerged as a therapeutic alternative to diabetic wound healing, reaching responsive cells while avoiding the deleterious effect of proteases and the biofilm on the wound's surface.

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Article Synopsis
  • * This study specifically looked at how growth hormone releasing peptide 6 (GHRP6) could prevent and potentially reverse HTS in rabbits, with treatments lasting 30 days and effects monitored through various methods.
  • * GHRP6 successfully prevented new HTS from forming without the side effects seen with the standard treatment (triamcinolone acetonide), but it didn't significantly improve existing scars; early data suggests GHRP6 works through various biological pathways related to skin cell functions and healing.
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Soon after epidermal growth factor (EGF) discovery, some models appeared demonstrating its property to enhance cutaneous wound healing. EGF was the first growth factor (GF) introduced in the clinical arena as a healing enhancer, exerting its mitogenic effects on epithelial, fibroblastoid, and endothelial cells via a tyrosine kinase membrane receptor. Compelling evidences from the 90s documented that, for EGF, locally prolonged bioavailability and hourly interaction with the receptor were necessary for a successful tissue response.

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Background: Growth hormone-releasing peptides (GHRPs) constitute a group of small synthetic peptides that stimulate the growth hormone secretion and the downstream axis activity. Mounting evidences since the early 1980s delineated unexpected pharmacological cardioprotective and cytoprotective properties for the GHRPs. However, despite intense basic pharmacological research, alternatives to prevent cell and tissue demise before lethal insults have remained as an empty niche in the clinical armamentarium.

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Article Synopsis
  • - GHRP-6 has cytoprotective effects and can reduce liver fibrosis while also showing potential in enhancing wound healing, as indicated by its impact on granulation tissue in skin wounds.
  • - In experiments with Wistar rats and rabbit models, GHRP-6 treatment facilitated faster wound closure by diminishing inflammatory responses and fibrotic cytokine expression.
  • - The research suggests that the CD36 receptor is a viable target for pharmacological approaches to improve wound healing aesthetics and reduce excessive scarring.
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Article Synopsis
  • * This study explored the effects of epidermal growth factor treatment on patients with DFUs, focusing on markers of oxidative stress and antioxidant levels.
  • * Results showed that DFU patients had high oxidative stress and low antioxidants, but treatment with epidermal growth factor improved their biochemical profiles, suggesting it helps restore redox balance.
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Since the inflammatory response and oxidative stress are involved in the stroke cascade, we evaluated here the effects of Phycocyanobilin (PCB, the C-Phycocyanin linked tetrapyrrole) on PC12 cell survival, the gene expression and the oxidative status of hypoperfused rat brain. After the permanent bilateral common carotid arteries occlusion (BCCAo), the animals were treated with saline or PCB, taking samples 24h post-surgery. Global gene expression was analyzed with GeneChip Rat Gene ST 1.

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Article Synopsis
  • Wound chronification and opportunistic infections significantly contribute to lower limb amputations in diabetic patients, and the exact molecular reasons for slow healing are not fully understood.
  • A case study of a female diabetic shows that after treating a plantar abscess, her wound still progressed poorly due to a lack of essential healing factors, revealing issues like poor matrix formation and limited blood vessel growth.
  • The study suggests that diabetic fibroblasts exhibit premature aging due to increased levels of proteins that inhibit cell proliferation (like p53 and p21) and decreased levels of growth-promoting signals (like Akt and mTOR), leading to slow wound healing.
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