Publications by authors named "Ysabella Za Van Sebille"
Article Synopsis
- Gastrointestinal toxicity caused by cancer treatments is a major reason for stopping treatment, which impacts patients' chances of remission and complicates drug development.* -
- Current animal models, especially rodents, have limitations in accurately predicting human responses, which calls for better alternatives like zebrafish.* -
- In this study, researchers used a specific zebrafish model to test the effects of different chemotherapy drugs on gut health, finding that while one drug showed damage in adult fish, the model needs improvements to better mimic human gastrointestinal toxicity.*
Tight junction and epithelial barrier disruption is a common trait of many gastrointestinal pathologies, including chemotherapy-induced gut toxicity. Currently, there are no validated in vitro models suitable for the study of chemotherapy-induced mucosal damage that allow paralleled functional and structural analyses of tight junction integrity. We therefore aimed to determine if a transparent, polyester membrane insert supports a polarized T84 monolayer with the phenotypically normal tight junctions.
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