High dose streptokinase for thrombolysis in the immediate postoperative period: a case report.

Venous thrombo-embolism is a life threatening condition with often non specific presentation. The detection of massive pulmonary embolism in the intra and immediate post-operative period is not only difficult due to the variety of conditions with similar presentation, but the therapy for the same is complicated with concerns of surgical and intracranial bleeding precluding various options. We present a case of massive pulmonary embolism presenting as intraoperative hypotension with an increased alveolar to arterial CO2 gradient which was subsequently managed with an accelerated regimen of streptokinase without increased postoperative bleeding.

Stereochemical studies on nucleic acid analogues. I. Conformations of alpha-nucleosides and alpha-nucleotides: interconversion of sugar puckers via O4'-exo.

The preferred conformations of ribo and deoxyribo alpha-nucleosides and alpha-nucleotides, the stereoisomers of the naturally occurring beta-isomers, are worked out by minimizing the conformational energy as a function of all the major parameters including the sugar ring conformations along the pseudorotation path. The results of the studies bring out certain distinct conformational features that are at variance with their beta counterparts. The range of glycosyl conformations are found to be not only quite restricted here but favor predominantly the anti conformation.

Stereochemical effects of non-ionic methylphosphonates on nucleotide conformations.

The preferred conformations of deoxyribo and ribonucleoside 3'-methylphosphonates are analysed by minimizing the conformational energy as a function of all the major parameters including the sugar ring for both the S- and R-isomers. The results show that neither the substitution nor the nature of the diastereomer affects significantly the preferred conformations compared to the naturally occurring nucleoside 3'-phosphates. The preferred range of C3'-O3' bond torsions or the phase angles of pseudorotation (P) of the sugar are unaffected.