Discovery of Aburatubolactams Reveals Biosynthetic Logic for Distinct 5/5-Type Polycyclic Tetramate Macrolactams.

A known polycyclic tetramate macrolactam (aburatubolactam C, ) and three new ones (aburatubolactams D-F, -, respectively) were isolated from the marine-derived sp. SCSIO 40070. The absolute configuration of was established by X-ray analysis.

Genome Mining and Biosynthetic Reconstitution of Fungal Depsidone Mollicellins Reveal a Dual Functional Cytochrome P450 for Ether Formation.

Depsidones are significant in structural diversity and broad in biological activities; however, their biosynthetic pathways have not been well understood and have attracted considerable attention. Herein, we heterologously reconstituted a depsidone encoding gene cluster from sp. SCSIO SY280D in A1145, leading to production of mollicellins, a representative family of depsidones, and discovering a bifunctional P450 monooxygenase that catalyzes both ether formation and hydroxylation in the biosynthesis of the mollicellins.

Diverse neolignans and lignans from an aqueous extract of the root head.

Neolignans and lignans with diverse new chemical structures, including eleven pairs of separated chiral enantiomers [(+)-/(-)--(+)-/(-)-, (+)-/(-)-, (+)-/(-)-, and (+)-/(-)--(+)-/(-)-], two achiral compounds ( and ), and an unseparated racemate [(±)-], together with a new natural product () and 21 known derivatives, were isolated from an aqueous extract of the root head (guitou). Among the chiral isolates, (+)-/(-)- and (+)-/(-)- were scalemic pairs with enantiomeric ratios of around 3:1 and 1.5:1, respectively, while others were enantiomeric equivalent pairs.

Anisotropic effect of a magnetic field on the neutron spin resonance in FeSe.

We use inelastic neutron scattering to study the effect of a magnetic field on the neutron spin resonance ( = 3.6 meV) of superconducting FeSe ( = 9 K). While a field aligned along the in-plane direction broadens and suppresses the resonance, a -axis aligned field does so much more efficiently, consistent with the anisotropic field-induced suppression of the superfluid density from the heat capacity measurements.