Association of precuneus Aβ burden with default mode network function.

Introduction: It remains unclear whether the local amyloid-beta (Aβ) burden in key regions within the default mode network (DMN) affects network and cognitive functions.

Methods: Participants included 1002 individuals from the Chinese Preclinical Alzheimer's Disease Study cohort who underwent 18F-florbetapir positron emission tomography resting-state functional magnetic resonance imaging scanning and neuropsychological tests. The correlations between precuneus (PRC) Aβ burden, DMN function, and cognitive function were investigated.

The chest CT perspective on sarcopenia: Exploring reference values for muscle mass quantity/quality and its application in elderly adults.

Objective: To determine reference values for diagnosing sarcopenia through chest CT scans and evaluate their suitability for use among the Chinese elderly population.

Methods: Chest CT scans were obtained from 500 healthy individuals aged 19-39. Skeletal muscle mass was assessed on chest CT at the level of T4 by the skeletal muscle area (T4SMA), skeletal muscle index (T4SMI), T12 erector spinae muscle area (T12ESMA), and T12 skeletal muscle index (T12SMI), as well as skeletal muscle density (SMD) at T4 and T12 levels.

Serum creatinine/cystatin C ratio is a predictor of all-cause mortality for older adults over 80 years.

Objective: Sarcopenia is a prevalent condition in the senior population and has been related to adverse outcomes. This study aimed to investigate the performance of the serum creatinine/cystatin C ratio (Cr/CysC) in predicting all-cause mortality in elders over 80 years.

Methods: A total of 486 older patients over 80 were enrolled in this study.

Lower serum FT3 within the reference range is associated with mortality for older adults over 80 years of age with sarcopenia.

Objective: Thyroid hormones stimulate myogenesis and muscle contraction and regulate skeletal muscle cell metabolism. However, the association between thyroid hormone levels and mortality in sarcopenic older adults remains elusive. The aim of this study was to investigate the relationship between thyroid hormones and all-cause mortality in people over 80 years of age with sarcopenia.