Publications by authors named "Youyi Chang"

Background: Patients with knee osteoarthritis (KOA) often experience persistent pain and functional impairment after total knee arthroplasty (TKA), which presents challenges for pain management. Accurate preoperative assessment of pain characteristics is crucial for tailoring individualized treatment plans. The PainDETECT Questionnaire has been widely used to identify neuropathic components in chronic pain and has been validated for its reliability and validity across various cultural contexts.

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  • * It involved a three-stage process: reviewing literature to form a model pool, collecting qualitative data from experts and patients to develop a preliminary Chinese TKA PROM (CTP), and validating the CTP through expert review and patient interviews.
  • * The final conceptual model identified six key concepts related to TKA—pain, symptom, function, quality of life, expectation, and satisfaction—leading to the development of 35 relevant assessment items for future psychometric testing and research.
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The rapid development of wearable sweat sensors has demonstrated their potential for continuous, non-invasive disease diagnosis and health monitoring. Emerging energy harvesters capable of converting various environmental energy sources-biomechanical, thermal, biochemical, and solar-into electrical energy are revolutionizing power solutions for wearable devices. Based on self-powered technology, the integration of the energy harvesters with wearable sweat sensors can drive the device for biosensing, signal processing, and data transmission.

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Background: Specific alterations in gut microbiota and metabolites have been linked to AMI, with CBLB potentially playing an essential role. However, the precise interactions remain understudied, creating a significant gap in our understanding. This study aims to address this by exploring these interactions in CBLB-intervened AMI mice using transcriptome sequencing, 16 S rDNA, and non-targeted metabolite analysis.

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  • Using CA125 thresholds of 70 U/ml or 35 U/ml in monitoring ovarian cancer may lead to missed relapses, prompting the need for better detection methods.
  • A study involving 162 patients found that using a CA125 level defined as 2×nadir significantly improved the sensitivity and timing of relapse detection compared to the standard threshold of 35 U/ml.
  • The findings suggest that the 2×nadir CA125 level is a more reliable early warning signal for relapse, aiding in timely imaging examinations for women with serous ovarian cancer.
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  • Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths, prompting research into herbal medicines with anti-tumor effects.
  • Psilostachyin C (PSC), extracted from Artemisia vulgaris L., significantly inhibits the growth, migration, and invasion of HCC cells, while also promoting apoptosis.
  • The study identifies CREBBP as a key target of PSC, as PSC reduces the expression of CREBBP and its downstream target GATAD2B, which is linked to the malignant behaviors of HCC cells.
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  • A new type of sensor, made from alumina inorganic molecularly imprinted polymer (MIP) combined with multi-walled carbon nanotubes (MWCNTs), has been developed for detecting uric acid in sweat using a one-step electro deposition technique.
  • The sensor was characterized using various advanced techniques (SEM, EDS, XPS, TEM), confirming that it has specific sites for uric acid recognition, leading to a high imprinting factor of about 2.338 compared to a non-molecularly imprinted counterpart.
  • The MWCNTs-AlO-MIP/GCE sensor achieved a low limit of detection (50 nM) and showed strong resistance to interference from other substances commonly found in sweat, making
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A micro-inertial measurement unit (MIMU) is usually used to sense the angular rate and acceleration of the flight carrier. In this study, multiple MEMS gyroscopes were used to form a spatial non-orthogonal array to construct a redundant MIMU system, and an optimal Kalman filter (KF) algorithm was established by a steady-state KF gain to combine array signals to improve the MIMU's accuracy. The noise correlation was used to optimize the geometric layout of the non-orthogonal array and reveal the mechanisms of influence of correlation and geometric layout on MIMU's performance improvement.

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As a two-dimensional planar material with low depth profile, a metasurface can generate non-classical phase distributions for the transmitted and reflected electromagnetic waves at its interface. Thus, it offers more flexibility to control the wave front. A traditional metasurface design process mainly adopts the forward prediction algorithm, such as Finite Difference Time Domain, combined with manual parameter optimization.

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Owing to their intrinsic amplifying effect together with chemical stability, graphene electrochemical transistor sensors (GECTs) are gaining momentum for sensing applications. However, the surface of GECTs for different detection substances must be modified with different recognition molecules, which was cumbersome and lack a universal method. Molecularly imprinted polymer (MIP) is a kind of polymer with specific recognition function for given molecules.

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Breast cancer (BC) tissues have been proved to harbor microorganisms, which could potentially contribute to oncogenesis. Formalin-fixed paraffin-embedded (FFPE) tissues are the most widespread clinical samples in BC research. To verify the potential of FFPE tissues in microbiological analysis, we analyzed the microbial communities of FFPE and fresh frozen (FF) tumor samples from 30 participants diagnosed with BC deploying 16S rRNA sequencing.

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Introduction: Olfactory ensheathing cells (OECs) are important transplantable cells for the treatment of spinal cord injury. However, information on the mechanism of OEC-derived extracellular vesicles (EVs) in nerve repair is scarce.

Methods: We cultured OECs and extracted the OEC-derived EVs, which were identified using a transmission electron microscope, nanoparticle flow cytometry, and western blotting.

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Background: Olfactory ensheathing cells (OECs) serve as a bridge by migrating at the site of spinal cord injury (SCI) to facilitate the repair of the neural structure and neural function. However, OEC migration at the injury site not only faces the complex and disordered internal environment but also is closely associated with the migration ability of OECs.

Methods: We extracted OECs from the olfactory bulb of SD rats aged <7 days old.

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Objectives: To investigate the correlation of R2* with vertebral fat fraction (FF) and bone mineral density (BMD), and to explore its role in the quantitative assessment of osteoporosis (OP).

Methods: A total of 83 patients with low back pain (59.77 ± 7.

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The aim of the present study was to elucidate the evolutionary trajectory of colon cells from normal colon mucosa, to adenoma, then to carcinoma in the same microenvironment. Normal colon, adenoma and carcinoma tissues from the same patient were analyzed by single-cell sequencing, which perfectly simulated the process of time-dependent colon cancer due to the same microenvironment. A total of 22 cell types were identified.

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With the rapid development of wearable electronic devices, health monitoring is undergoing a fundamental shift from hospital-centered treatment to patient-centered diagnosis. Solution-gated graphene transistors provide an effective platform for developing high-sensitivity wearable devices due to their unique signal amplification, low energy consumption, and compatibility for miniaturization. However, it is still a major challenge to perform real-time sweat composition monitoring directly on the dry skin surface.

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Amino functionalized zirconium-based metal-organic framework (NH-UiO-66) and zinc-based zeolitic imidazolate framework (ZIF-8) were integrated to develop a core-shell architectured hybrid material (NH-UiO-66@ZIF-8, NU66@Z8). The morphology and structure evolutions of core-shell NU6@Z8 were investigated by FE-SEM, XRD, FTIR, and XPS. The NU66@Z8 combined with carboxylated multi-walled carbon nanotubes (CMWCNT) was deposited on a glassy carbon electrode (GCE) for fabricating an electrochemical platform towards detecting Pb and Cu.

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The digital polymerase chain reaction (dPCR) technique can quantify specific sequences of deoxyribonucleic acid using either a droplet-based or chip-based system. dPCR duplexing methods in a single fluorescence channel are typically based on the difference in fluorescence amplitude (F) between two targets. The different targets are distinguished from each other by the F-value variation using non-equal probe concentrations or different target lengths.

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Objectives: To evaluate the accuracy of dual-energy computed tomography (DECT) in quantifying bone marrow adipose tissue (BMAT) and its applicability in the study of osteoporosis (OP).

Methods: A total of 83 patients with low back pain (59.77 ± 7.

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  • LHPP is a histidine phosphatase protein that may help suppress cancer progression, but research on its effects across different tumor types has been limited.
  • A bioinformatics study analyzed LHPP's impact on 33 cancer types, revealing that lower LHPP levels are linked to poorer outcomes; specifically, higher LHPP expression is associated with better survival in patients with brain glioma and renal carcinoma.
  • In laboratory tests, boosting LHPP reduced the growth and spread of gastric cancer cells and affected markers related to the cell cycle and epithelial-mesenchymal transition, suggesting LHPP might be a potential target for new cancer treatments.
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Tin-based perovskites are a promising candidates to replace their toxic lead-based counterparts in optoelectronic applications, such as light-emitting diodes (LEDs). However, the development of tin perovskite LEDs is slow due to the challenge of obtaining high-quality tin perovskite films. Here, a vapor-assisted spin-coating method is developed to achieve high-quality tin perovskites and high-efficiency LEDs.

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Background: The relationship between ambulatory arterial stiffness index (AASI) and left ventricular diastolic dysfunction (LVDD) in patients with heart failure with preserved ejection fraction (HFpEF) is unknown. We aimed to investigate the association between the AASI and LVDD in HFpEF.

Methods: We prospective enrolled consecutive patients with HFpEF in Chongqing, China.

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Background: Osteoarthritis (OA) and Kashin-Beck disease (KBD) both are two severe osteochondral disorders. In this study, we aimed to compare the gut microbiota structure between OA and KBD patients.

Methods: Fecal samples collected from OA and KBD patients were used to characterize the gut microbiota using 16S rDNA gene sequencing.

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A new approach is presented to fabricate flexible surface-enhanced Raman scattering (SERS) substrate of Ag nanocubes monolayer-modified polydimethylsiloxane (Ag NCs/PDMS) through a powerful three-phase interface self-assemble method. The morphologies and crystal structures were characterized by scanning electron microscopy and X-ray diffraction. The self-assembled Ag NCs/PDMS substrate exhibited high SERS activity and good signal homogeneity, which was successfully used for quantitative detection of thiram; the detection limit reached 10 ng/mL, and the linear range is 10-1000 ng/mL.

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Owing to their excellent optoelectronic properties, quasi-2D perovskites with self-assembled multiple quantum well (MQW) structures have shown great potential in light-emitting diode (LED) applications. Understanding the correlation between the bulky cation, quantum well assembly, and optoelectronic properties of a quasi-2D perovskite is important. Here, we demonstrate that the dipole moment of the bulky cation can be one of the fundamental factors that controls the distribution and crystallinity of different quantum wells.

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