A Novel Algorithm With Paired Predictive Indexes to Stratify the Risk Levels of Neonates With Invasive Bacterial Infections: A Multicenter Cohort Study.

Background: Our aim was to develop a predictive model comprising clinical and laboratory parameters for early identification of full-term neonates with different risks of invasive bacterial infections (IBIs).

Methods: We conducted a retrospective study including 1053 neonates presenting in 9 tertiary hospitals in China from January 2010 to August 2019. An algorithm with paired predictive indexes (PPIs) for risk stratification of neonatal IBIs was developed.

Antibiotic resistance in neonates in China 2012-2019: A multicenter study.

Background: To investigate antibiotic resistance of pathogens responsible for neonatal invasive bacterial infections (IBIs) in China.

Methods: Cross-sectional study of neonates with IBI evaluated in nine hospitals in China (January 2012-August 2019). Antibiotic resistance patterns of pathogens responsible for neonatal IBIs were analyzed.

A sequential guide to identify neonates with low bacterial meningitis risk: a multicenter study.

Objective: To derive and validate a predictive algorithm integrating clinical and laboratory parameters to stratify a full-term neonate's risk level of having bacterial meningitis (BM).

Methods: A multicentered dataset was categorized into derivation (689 full-term neonates aged ≤28 days with a lumbar puncture [LP]) and external validation (383 neonates) datasets. A sequential algorithm with risk stratification for neonatal BM was constructed.

An improved clinical prediction rule for identifying neonatal bacterial meningitis: a multicenter cohort study.

Background: To refine the bacterial meningitis (BM) score by improving its predictability of neonatal BM.

Methods: A multicenter, ambispective cohort study was conducted in China, comprising 9 hospitals (retrospective cohort: January 2001 to December 2017; prospective cohort: January 2018 to August 2019). Of 3,504 eligible full-term neonates, 475 neonates with cerebrospinal fluid (CSF) pleocytosis were included.

Effects of Nasal Continuous Positive Airway Pressure on Cerebral Hemodynamics in Preterm Infants.

To evaluate the effects of pressure levels on cerebral hemodynamics in premature infants receiving nasal continuous positive airway pressure (nCPAP) during the first 3 days of life. Forty-four preterm infants treated with nCPAP were divided into two groups: very preterm infants [gestational age 1 (GA1), GA < 32 weeks, = 24] and moderate/late preterm infants (GA2 group, GA 32-37 weeks, = 20). During monitoring, pressure levels were set at 4 → 6 → 8 → 4 cmHO, and cerebral hemodynamics was assessed by near-infrared spectroscopy (NIRS).

Is there a potential link between vitamin D and pulmonary morbidities in preterm infants?

Background: There hasn't been conclusive proof about the association between vitamin D and pulmonary morbidities of prematurity.

Methods: 106 preterm infants were retrospectively included into this study. Clinical data and blood samples of all the patients were collected within 24 h of admission.

Infantile Pompe disease: A case report and review of the Chinese literature.

Pompe disease, also known as glycogen storage disease type II, is caused by acid maltase deficiency, and can lead to lysosomal glycogen storage. The primal manifestations may be observed in children and adults, and also in infants. In general, the clinical spectrum in infants is more progressive and lethal than that in older patients.

Mild encephalitis/encephalopathy with a reversible splenial lesion: five cases and a literature review.

The aim of this study was to explore the clinical characteristics and etiology of mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) in China by retrospectively analyzing five MERS cases from the Jiangsu Provincial Hospital within a total of 27 reported MERS cases from available Chinese literature. Most of the 27 cases originated near the eastern and southern parts of China. Ages for 23 MERS cases were under 30 years and the female-to-male ratio was 1:1.