Publications by authors named "Youxiang Jiang"
Article Synopsis
- Intimal hyperplasia (IH) is a major issue in vascular interventions, and this study investigates the role of gangliosides GA2 in its development.
- Researchers found that GA2 levels were significantly higher in atherosclerotic mouse aortae and plasma, and injecting GA2 worsened IH by interacting with macrophages.
- The study reveals that GA2 activates caspase-4 and promotes pyroptosis in macrophages, suggesting a new mechanism for IH that could lead to potential diagnostic and treatment strategies.
Cardiac dysfunction, an early complication of endotoxemia, is the major cause of death in intensive care units. No specific therapy is available at present for this cardiac dysfunction. Here, we show that the N-terminal gasdermin D (GSDMD-N) initiates mitochondrial apoptotic pore and cardiac dysfunction by directly interacting with cardiolipin oxidized by complex II-generated reactive oxygen species (ROS) during endotoxemia.
View Article and Find Full Text PDFRIPK1 is crucial in the inflammatory response. The process of vascular graft remodeling is also involved in endothelial inflammation, which can influence the behavior of smooth muscle cells. However, the role of endothelial RIPK1 in arterial bypass grafts remains unknown.
View Article and Find Full Text PDFBackground & Aims: The liver plays crucial roles in the regulation of immune defense during acute systemic infections. However, the roles of liver cellular clusters and intercellular communication in the progression of endotoxemia have not been well-characterized.
Methods: Single-cell RNA sequencing analysis was performed, and the transcriptomes of 19,795 single liver cells from healthy and endotoxic mice were profiled.