Deep learning model for automated detection of fresh and old vertebral fractures on thoracolumbar CT.

Purpose: To develop a deep learning system for automatic segmentation of compression fracture vertebral bodies on thoracolumbar CT and differentiate between fresh and old fractures.

Methods: We included patients with thoracolumbar fractures treated at our Hospital South Campus from January 2020 to December 2023, with prospective validation from January to June 2024, and used data from the North Campus from January to December 2023 for external validation. Fresh fractures were defined as back pain lasting less than 4 weeks, with MRI showing bone marrow edema (BME).

Relationship Between Paraspinal Sarcopenia and Lumbar Alignment and Facet Joint Osteoarthritis in Patients with Degenerative Lumbar Spinal Stenosis.

Study Design: Retrospective study analysis.

Objective: To explore association between degenerative spinal conditions and paraspinal sarcopenia in patients with severe degenerative lumbar spinal stenosis (DLSS).

Background: Paraspinal muscles plays an essential role in stabilizing the spine.

IL-32 aggravates metabolic disturbance in human nucleus pulposus cells by activating FAT4-mediated Hippo/YAP signaling.

Extracellular matrix (ECM) metabolism disorders in the inflammatory microenvironment play a key role in the pathogenesis of intervertebral disc degeneration (IDD). Interleukin-32 (IL-32) has been reported to be involved in the progression of various inflammatory diseases; however, it remains unclear whether it participates in the matrix metabolism of nucleus pulposus (NP) cells. Therefore, this study aimed to investigate the mechanism of IL-32 on regulating the ECM metabolism in the inflammatory microenvironment.

Maslinic acid alleviates intervertebral disc degeneration by inhibiting the PI3K/AKT and NF-κB signaling pathways.

Intervertebral disc degeneration (IDD) is the cause of low back pain (LBP), and recent research has suggested that inflammatory cytokines play a significant role in this process. Maslinic acid (MA), a natural compound found in olive plants ( ), has anti-inflammatory properties, but its potential for treating IDD is unclear. The current study aims to investigate the effects of MA on TNFα-induced IDD and in other models.

Low-complexity and low-latency equalization technique - probabilistic noise cancellation.

Both inside data centers (DCs) and in short optical links between data centers (DC campuses), intensity-modulation and direct-detection (IMDD) systems using four-level pulse amplitude modulation (PAM4) will dominate this decade due to low transceiver price and power consumption. The next DC transceiver generation based on 100 Gbaud PAM4 will require advanced digital signal processing (DSP) algorithms and more powerful forward error correction (FEC) codes. Because of bandwidth limitations, the conventional DC DSP based on a few-tap linear feed-forward equalizer (FFE) is likely to be upgraded to more complex but still low-complexity Volterra equalizers followed by a noise whitening filter and either a maximum likelihood sequence estimation (MLSE) or a maximum a posteriori probability (MAP) algorithm.

Facet joint tropism, pelvic incidence and intervertebral height index: associations with facet joint osteoarthritis in lumbar spinal stenosis.

Background Context: Facet joint osteoarthritis (FJOA) is associated with lumbar disc degeneration and has a significant role in the development of lumbar spinal stenosis (LSS). The relationship between various radiographic parameters and the grade of FJOA is not well understood.

Purpose: To explore radiographical parameters associated with FJOA in LSS without lumbar dynamic instability.

Constructing intervertebral disc degeneration animal model: A review of current models.

Low back pain is one of the top disorders that leads to disability and affects disability-adjusted life years (DALY) globally. Intervertebral disc degeneration (IDD) and subsequent discogenic pain composed major causes of low back pain. Recent studies have identified several important risk factors contributing to IDD's development, such as inflammation, mechanical imbalance, and aging.

Effect of Milling Processing Parameters on the Surface Roughness and Tool Cutting Forces of T2 Pure Copper.

In this paper, the responses of machined surface roughness and milling tool cutting forces under the different milling processing parameters (cutting speed , feed rate , and axial cutting depth ) are experimentally investigated to meet the increasing requirements for the mechanical machining of T2 pure copper. The effects of different milling processing parameters on cutting force and tool displacement acceleration are studied based on orthogonal and single-factor milling experiments. The three-dimensional morphologies of the workpieces are observed, and a white-light topography instrument measures the surface roughness.

Rotating Bending Fatigue Behaviors of C17200 Beryllium Copper Alloy at High Temperatures.

The purpose of this paper is to investigate the fatigue properties of C17200 alloy under the condition of quenching aging heat treatment at high temperatures, and to provide a design reference for its application in a certain temperature range. For this purpose, the tensile and rotary bending fatigue (RBF) tests were carried out at different temperatures (25 °C, 150 °C, 350 °C, and 450 °C). The tensile strength was obtained, and relationships between the applied bending stress levels and the number of fatigue fracture cycles were fitted to the stress-life (S-N) curves, and the related equations were determined.

YTHDF1 Enhances Chondrogenic Differentiation by Activating the Wnt/β-Catenin Signaling Pathway.

Cartilage is derived from the chondrogenic differentiation of stem cells, for which the regulatory mechanism has not been fully elucidated. N6-methyladenosine (m6A) messenger RNA (mRNA) methylation is the most common posttranscriptional modification in eukaryotic mRNAs and is mediated by m6A regulators. However, whether m6A regulators play roles in chondrogenic differentiation is unknown.

Effects of physiotherapeutic scoliosis-specific exercise in patients with mild juvenile scoliosis.

Study Design: A combined retrospective and prospective analysis on the therapeutic effect of physiotherapeutic scoliosis-specific exercise (PSSE) in mild juvenile idiopathic scoliosis (JIS) patients.

Background: At present, patients with mild JIS are generally treated by observation without any interventional treatment. This study analyzed the effects of PSSE on mild JIS, which provided a new approach for the treatment of JIS.

Apical region correction and global balance: a 3-rods surgical strategy for the treatment of severe and rigid scoliosis.

Background: The treatment of severe and rigid scoliosis is challenging. We developed a surgical strategy for severe and rigid scoliosis since 2014. This study aimed to retrospectively analyze the safety and efficacy of apical region correction and global balance with 3 rods as a surgical strategy for the treatment of severe and rigid scoliosis.

Irisin Ameliorates Intervertebral Disc Degeneration by Activating LATS/YAP/CTGF Signaling.

Unbalanced metabolism of an extracellular matrix (ECM) in nucleus pulposus cells (NPCs) is widely acknowledged as the primary cause of intervertebral disc degeneration (IDD). Irisin, a novel myokine, is cleaved from fibronectin type III domain-containing 5 (FNDC5) and has recently been proven to regulate the metabolism of ECM. However, little is known about its potential on NPCs and the development of IDD.

Erratum: A novel probe for measuring tissue bioelectrical impedance to enhance pedicle screw placement in spinal surgery.

[This corrects the article on p. 2205 in vol. 10, PMID: 30093957.

Melatonin Synergizes With Methylprednisolone to Ameliorate Acute Spinal Cord Injury.

Methylprednisolone (MP) is the drug of choice for treating spinal cord injury (SCI), but the aggressive dosage regimen used often results in adverse side effects. Therefore, MP should be combined with other drugs to lower the required dose. Melatonin is effective in alleviating nerve damage and inhibiting axonal degeneration.

Is physical capacity correlated with health-related quality of life in patients with adolescent idiopathic scoliosis?

Background: There have been no report about the association between physical capacity and health-related quality of life in patients with adolescent idiopathic structural scoliosis (AIS). This study aims to investigate the correlation between dynamic cardiopulmonary capacity and quality of life in AIS patients.

Methods: This retrospective study involved 63 patients.

Tribological Properties of Micro-Groove Cemented Carbide by Laser Processing.

Tool wear is the main factor of tool failure in cutting difficult-to-machine materials. This paper aims to analyze the anti-friction mechanism of laser machining micro-groove cemented carbide. Firstly, micro-grooves were prepared on the cemented carbide surface by laser processing.

The Research of Tool Wear Mechanism for High-Speed Milling ADC12 Aluminum Alloy Considering the Cutting Force Effect.

Tool wear is a major cause of accelerated tool failure during the milling of aluminum alloy. The periodically cutting force directly affect the cutting heat and tool wear due to the intermittent cutting characteristics of the milling process. The focus of this paper is to analyze the influence of the variation of cutting force on tool wear behavior.