Discovery of CN0 as a novel proteolysis-targeting chimera (PROTAC) degrader of PARP1 that can activate the cGAS/STING immunity pathway combined with daunorubicin.

Poly ADP-ribose polymerase 1 (PARP1) plays an essential role in DNA repair signaling, rendering it an attractive target for cancer treatment. Despite the success of PARP1 inhibitors (PARPis), only a few patients can currently benefit from PARPis. Moreover, drug resistance to PARPis occurs during clinical treatment.

Knockdown of GPRC5B alleviates the high glucose-induced inflammation and extracellular matrix deposition of podocyte through inhibiting NF-κB pathway.

Background: Diabetes is a serious disease that could greatly increase the risk of cardiovascular complications, whereas the underlying pathology of DN is still unknown. GPRC5B is a member of the RAIG subfamily of type 3 (family C) GPCR, and its role in DN is still unclear.

Objective: To unveil the role of GPRC5B in diabetic nephropathy (DN) progression and investigate the potential signaling pathway.

Hydro-ecological controls on riverine organic carbon dynamics in the tropical monsoon region.

Transport fluxes and properties of riverine organic carbon in the tropical monsoon region were the vital parameters in the global riverine organic carbon fluxes budget. The study focused on the riverine organic carbon in the Changhuajiang River (CHJR), locating at the mid-west of the Hainan Island, China. Dissolved organic carbon (DOC) concentrations in the CHJR ranged from 0.

A new supramolecular gel via host-guest complexation with cucurbit[8]uril and N-(4-diethylaminobenzyl)chitosan.

A novel supramolecular gel has been prepared via host-guest interaction between cucurbit[8]uril (Q[8]) and N-(4-diethylaminobenzyl)chitosan (EBCS). The structure of supramolecular gel has been characterized. The spectrum of (1)H NMR demonstrated the benzene ring of EBCS is reside inside the hydrophobic cavity of Q[8] and the host-guest interaction between Q[8] and EBCS was the main driving force for the formation of the supramolecular gel.

Cathodic electrochemiluminescence at C/CxO(1-x) electrodes for the fabrication of label-free biosensors.

Cathodic electrochemiluminescence (ECL) is firstly observed at a carbon oxide covered glassy carbon (C/C(x)O(1-x)) electrode as a large cathodic pulse polarization is applied. This insulating carbon oxide (C(x)O(1-x)) film is constructed on a glassy carbon (GC) substrate by electrochemical oxidization in basic media. The film properties, such as the composition of carbon and oxygen, and the thickness as well, can be controlled by the potential and the duration in the oxidizing process.

Synthesis and characterization of three ytterbium coordination polymers featuring various cationic species and a luminescence study of a terbium analogue with open channels.

Four novel metal-organic frameworks with 4,4'-oxybis(benzoate) (OBA) ligands and suitable cationic species, [NH(3)(CH(2))(2)NH(3)](0.5)[Yb(OBA)(2)(H(2)O)] (1), (NH(4))[Yb(OBA)(2)(H(2)O)(2)] (2), Na[Yb(OBA)(2)] x 0.4 DMF x 1.

Preparation and characterization of N-(2-carboxybenzyl)chitosan as a potential pH-sensitive hydrogel for drug delivery.

A novel water-soluble chitosan derivative [N-(2-carboxybenzyl)chitosan, CBCS] was synthesized. The chemical structure of CBCS was characterized by FTIR, (1)H NMR and UV spectroscopies. The degree of substitution (DS) of N-2-carboxybenzyl was determined by colloid titration.