Dual-action kinase inhibitors influence p38α MAP kinase dephosphorylation.

Reversible protein phosphorylation directs essential cellular processes including cell division, cell growth, cell death, inflammation, and differentiation. Because protein phosphorylation drives diverse diseases, kinases and phosphatases have been targets for drug discovery, with some achieving remarkable clinical success. Most protein kinases are activated by phosphorylation of their activation loops, which shifts the conformational equilibrium of the kinase toward the active state.

Dual-Action Kinase Inhibitors Influence p38α MAP Kinase Dephosphorylation.

Reversible protein phosphorylation directs essential cellular processes including cell division, cell growth, cell death, inflammation, and differentiation. Because protein phosphorylation drives diverse diseases, kinases and phosphatases have been targets for drug discovery, with some achieving remarkable clinical success. Most protein kinases are activated by phosphorylation of their activation loops, which shifts the conformational equilibrium of the kinase towards the active state.

High-Selectivity Planar Thermal Emitter with a Stable Temperature over 1400 K for a Thermophotovoltaic System.

A selective thermal emitter with superior thermal stability and perfect selective thermal emission in specific bands can facilitate the lifting of the thermophotovoltaic (TPV) energy conversion efficiency in TPV systems. Scalable planar selective thermal emitters with superior spectral selectivity and robust high-temperature stability are desired to meet the requirements of large-scale deployments of TPV systems. However, stably reradiating the available thermal photons at above 1273 K remains a significant challenge for selective thermal emitters.