Publications by authors named "Youssra Boustany"
Article Synopsis
- This study analyzed genetic changes in non-small cell lung cancer (NSCLC) patients from Morocco and compared them to data from the Cancer Genome Atlas (TCGA).
- Out of 76 tissue samples analyzed, 70 had genetic alterations, with 234 changes identified across 18 genes that could influence targeted therapy decisions.
- Significant differences were found in the prevalence of certain mutations between Moroccan patients and TCGA data, reinforcing the importance of next-generation sequencing for effective diagnosis and treatment planning in NSCLC.
Background: Epidermal growth factor receptor (EGFR) mutation status is of a major clinical significance in non-small cell lung cancer (NSCLC) management, as it guides therapeutic decision making to target patients for a better response to therapy. This implicates the introduction of EGFR mutation analysis as the standard of care for Moroccan NSCLC patients, which in itself entails the implementation of targeted methods for routine EGFR mutation analysis in our laboratories. In this study, we aimed to present 2 targeted methods for EGFR mutation identification and to determine the prevalence and spectrum of EGFR mutations in NSCLC Moroccan patients.
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