Publications by authors named "Youssef M Fadel"
Article Synopsis
- Breast cancer is the leading cancer-related cause of death in women, highlighting the urgent need for new treatment strategies.
- Recent research suggests that reactivating Tumor Suppressor Genes (TSGs) could be a promising intervention by understanding their defects and identifying those under positive selection in mammalian genomes.
- The study identified critical positively selected sites in TSGs like BRCA1 and BRCA2, which are vital for DNA repair, and has developed an automated tool to aid future research on these genetic targets.
Wilms tumor (WT) is a pediatric kidney cancer associated with poor outcomes in patients with unfavorable histological features such as anaplasia. Small non-coding RNAs, such as miRNAs, are known to be involved in WT pathogenesis. However, research on the clinical potential of blood-based miRNAs is limited.
View Article and Find Full Text PDFThe global spread of the SARS-CoV-2 pandemic, originating in Wuhan, China, has had profound consequences on both health and the economy. Traditional alignment-based phylogenetic tree methods for tracking epidemic dynamics demand substantial computational power due to the growing number of sequenced strains. Consequently, there is a pressing need for an alignment-free approach to characterize these strains and monitor the dynamics of various variants.
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