Left ventricular end-systolic stress/diameter relation as a contractility index and as a predictor of survival. Independence of preload after normalization for end-diastolic diameter.

The independence of the slope of the left ventricular (LV) end-systolic stress/end systolic diameter (ESS/ESD) relation of preload (PL) after normalization for end-diastolic diameter (EDD), and the reliability of both the original and the normalized slope as contractility and prognostic indices, were assessed. We studied echocardiographically, hemodynamically, and with carotid pulse tracing, 25 normal subjects, 18 patients with coronary artery disease having a normal ejection fraction (EF), and 30 patients with idiopathic dilated cardiomyopathy (DCM). The arterial pressure was changed with intravenous infusion of phenylephrine.