Effect of surface functionalization on DNA sequencing using MXene-based nanopores.

As one of the most promising types of label-free nanopores has great potential for DNA sequencing fast detection of different DNA bases. As one of the most promising types of label-free nanopores, two-dimensional nanopore materials have been developed over the past two decades. However, how to detect different DNA bases efficiently and accurately is still a challenging problem.

Exploring the non-monotonic DNA capture behavior in a charged graphene nanopore.

Nanopore-based biomolecule detection has emerged as a promising and sought-after innovation, offering high throughput, rapidity, label-free analysis, and cost-effectiveness, with potential applications in personalized medicine. However, achieving efficient and tunable biomolecule capture into the nanopore remains a significant challenge. In this study, we employ all-atom molecular dynamics simulations to investigate the capture of double-stranded DNA (dsDNA) molecules into graphene nanopores with varying positive charges.

Correlation between clinicopathological characteristics and the clinical prognosis of patients with gastroenteropancreatic neuroendocrine tumors.

Gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are one of the most common types of NETs, accounting for 65-75% of all NETs. However, epidemiological characteristics of patients with GEP-NETs in China are still lacking. The present retrospective study aimed to investigate the local epidemiology of GEP-NETs and assess the prognostic factors in China.

Controlling ion transport in a CN-based nanochannel with tunable interlayer spacing.

Selective ion transport through a nanochannel formed by stacked two-dimensional materials plays a key role in water desalination, nanofiltration, and ion separation. Although there have been many functional nanomaterials used in these applications, how to well control ion transport in a laminar structure so as to obtain the desired selectivity still remains a challenging problem. In the present work, the transport of ions through a CN-based nanochannel is investigated by using all-atom molecular dynamics simulation.

Tailoring the component of protein corona via simple chemistry.

Control over the protein corona of nanomaterials allows them to function better. Here, by taking graphene/gold as examples, we comprehensively assessed the association of surface properties with the protein corona. As revealed by in vitro measurements and computations, the interaction between graphene/gold and HSA/IgE was inversely correlated with the hydroxyl group availability, whereas the interaction between that and ApoE was comparatively less relevant.

Designing a nanoparticle-containing polymeric substrate for detecting cancer cells by computer simulations.

Efficient and accurate detection of cancer cells (from normal cells) is of great importance in cancer diagnosis and prognosis. In this work, we design a new type of polymeric substrate containing nanoparticles for detecting cancers by the dissipative particle dynamics (DPD) simulation. It is found that the cancer cells and the normal cells can be indeed distinguished since the uptake number of nanoparticles from the substrate is different.

Ion transport through a nanoporous CN membrane: the effect of electric field and layer number.

Ion transport through a two-dimensional membrane with nanopores plays an important role in many scientific and technical applications (, water desalination, ion separation and nanofiltration). Although there have been many two-dimensional membranes for these applications, the problem of how to controllably fabricate nanopores with proper shape and size still remains challenging. In the present work, the transport of ions through a CN membrane with intrinsically regular and uniformly distributed nanopores is investigated using all-atom molecular dynamic simulations.

Counteranion Modulated Crystal Growth and Function of One-Dimensional Homochiral Coordination Polymers: Morphology, Structures, and Magnetic Properties.

Four pairs of enantiomeric dysprosium(III) phosphonates, namely, R- or S-[Dy(pempH)(pempH)](NO)·12HO ( R-1 or S-1), R- or S-[Dy(pempH)(pempH)]Cl·2HO ( R-2 or S-2), R- or S-[Dy(pempH)(pempH)]Br·2HO ( R-3 or S-3), and R- or S-[Dy(pempH)(pempH)](CFSO)·22HO ( R-4 or S-4) are reported, where R- or S-pempH represent R- or S-(1-phenylethyl)amino] methylphosphonic acid. All show homochiral chain structures, charge-balanced by counteranions. A comparison of the crystal morphologies of the R-isomers reveals that the overall shapes are quite similar for the four compounds, but the aspect ratio changes remarkably following the sequence: R-1 < R-2 < R-3 < R-4.

Computational investigation on DNA sequencing using functionalized graphene nanopores.

Fast, low-cost and reliable DNA sequencing is one of the most desirable innovations in recent years, which can pave the way for high throughput, label-free and inexpensive personalized genome sequencing techniques. Although graphene-based nanopore devices hold great promise for next-generation DNA sequencing, it is still a challenging problem to detect different DNA sequences efficiently and accurately. In the present work, the translocation of four homogeneous DNA strands (i.