Precipitation of Ibuprofen Sodium using compressed carbon dioxide as antisolvent.

Precipitation with compressed antisolvent (PCA) process was used to produce fine particles of Ibuprofen Sodium with the ultimate goal of obtaining controlled particle size and size distribution of this non-steroidal anti-inflammatory drug. This systematic investigation shows that particle size and size distribution of the final product can be controlled reproducibly by varying a number operating parameters such as antisolvent addition rate, temperature, concentration, and solution addition rate. The mechanisms that control particle size and particle size distribution were explained by invoking the differences in the relative weight of primary, secondary nucleation and growth kinetic phenomena.

Experimental study of the GAS process for producing microparticles of beclomethasone-17,21-dipropionate suitable for pulmonary delivery.

In this study the micronization of beclomethasone-17,21-dipropionate (BECD), used as an inhaled steroid for the treatment of asthma, was studied using the gas-antisolvent (GAS) process as a "green" alternative to pharmaceutical recrystallization. A systematic investigation of the influence of the key GAS process parameters: antisolvent addition rate (1, 50, 75 and 100 ml/min), temperature (25, 32.5, 40 and 52.