Effect of Nigella sativa and Fenugreek on the Pharmacokinetics and Pharmacodynamics of Amlodipine in Hypertensive Rats.

Background: The present article is related to in-vitro and in-vivo herb-drug interaction studies.

Objectives: This study aimed to investigate the effect of Nigella sativa and fenugreek on the pharmacodynamics and pharmacokinetics of amlodipine.

Method: Hypertensive rats of group-I were treated with amlodipine and rats of group-II and III were treated with N.