Publications by authors named "Yourong Lei"
Necroptosis is a type of caspase-independent cell death, and it plays a critical role in regulating the development of cancer. To date, little is known about the role of necroptosis-related genes (NRGs) in clear cell renal cell carcinoma (ccRCC). In this study, we downloaded data regarding the expression of NRGs and overall survival (OS) from The Cancer Genome Atlas (TCGA) database and constructed a risk model to determine the prognostic features of necroptosis using COX regression analysis.
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- Acute kidney injury (AKI) is primarily caused by renal ischaemia reperfusion injury (IRI), where ferroptosis and oxidative stress are significant contributors, though the exact mechanism remains unclear.
- The study identifies lysine-specific demethylase 1 (LSD1) as positively correlated with renal IRI and demonstrates that using LSD1 inhibitors like TCP can reduce tissue damage by mitigating ferroptosis and oxidative stress.
- Inhibition of LSD1 disrupts the TLR4/NOX4 signaling pathway, leading to decreased oxidative stress and ferroptosis, suggesting that targeting LSD1 may offer a new therapeutic approach for treating renal IRI.
Background: Few data are available on hospital-wide incidence of central line-associated bloodstream infection (CLABSI) rates in patients with central venous catheter (CVC) in China, where many systemic obstacles holding back evidence-based guidelines implementation exist.
Methods: This study was conducted prospectively in 2 phases. The baseline and intervention phases were performed in a teaching hospital in China, between January 2017 and October 2018.
[Effects of hydrodynamics-mediated RNAi on Mfn2 expression, blood sugar and fat levels in mice].
Zhonghua Gan Zang Bing Za Zhi
October 2010
Objective: To investigate the effects of hydrodynamics-mediated RNAi for Mfn2 gene expression in liver and the levels of blood sugar and fat in mice.
Methods: Fifty-six male BALB/c mice were randomly divided into normal control group (NC, n = 8), negative control group (HK, n = 24) and transfection group (Mfn2, n = 24) according to random digits table. 1.