Association between glioma and neurodegenerative diseases risk: a two-sample bi-directional Mendelian randomization analysis.

Background: Earlier observational studies have demonstrated a correlation between glioma and the risk of neurodegenerative diseases (NDs), but the causality and direction of their associations remain unclear. The objective of this study was to ascertain the causal link between glioma and NDs using Mendelian randomization (MR) methodology.

Methods: Genome-wide association study (GWAS) data were used in a two-sample bi-directional MR analysis.

Identification of the global regulatory roles of RraA via the integrative transcriptome and proteome in .

Bacterial ribonuclease E (RNase E) is vital for posttranscriptional regulation by degrading and processing RNA. The RraA protein inhibits RNase E activity through protein-protein interactions, exerting a global regulatory effect on gene expression. However, the specific role of RraA remains unclear.

Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis.

Background: Glioma is one of the leading types of brain tumor, but few etiologic factors of primary glioma have been identified. Previous observational research has shown an association between viral infection and glioma risk. In this study, we used Mendelian randomization (MR) analysis to explore the direction and magnitude of the causal relationship between viral infection and glioma.

Development of an MCL-1-related prognostic signature and inhibitors screening for glioblastoma.

The effect of the conventional treatment methods of glioblastoma (GBM) is poor and the prognosis of patients is poor. The expression of MCL-1 in GBM is significantly increased, which shows a high application value in targeted therapy. In this study, we predicted the prognosis of glioblastoma patients, and therefore constructed MCL-1 related prognostic signature (MPS) and the development of MCL-1 small molecule inhibitors.

Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study.

Background: Meningiomas are one of the most common intracranial tumors, and the current understanding of meningioma pathology is still incomplete. Inflammatory factors play an important role in the pathophysiology of meningioma, but the causal relationship between inflammatory factors and meningioma is still unclear.

Method: Mendelian randomization (MR) is an effective statistical method for reducing bias based on whole genome sequencing data.

Cerebrospinal fluid protein levels are elevated 100 times in a Leptomeningeal metastasis patient: a case report and literature review.

Leptomeningeal metastasis (LM) has a high degree of malignancy and high mortality. We describe a patient admitted to hospital with acute lower extremity weakness, dysuria, and high intracranial pressure. Enhanced magnetic resonance imaging (MRI) showed extensive enhancement of the leptomeningeal and spinal meninges with multiple nodular changes and extensive fusion.

Experimental demonstration of the magnetic field concentration effect in circuit-based magnetic near-zero index media.

The electromagnetic field concentration effect can greatly enhance light-matter interaction and is of practical interest in applications such as wireless power transfer and sensors. Zero-index media, unusual materials with near-zero relative permittivity (ɛ) and/or permeability (µ), play a key role in tailoring the properties of electromagnetic waves in unique ways. In this work, circuit-based isotropic µ-near-zero (MNZ) media were theoretically proposed and constructed based on two-dimensional transmission lines with lumped elements.

Exploring spatial change and gravity center movement for ecosystem services value using a spatially explicit ecosystem services value index and gravity model.

Spatially explicit ecosystem services valuation and change is a newly developing area of research in the field of ecology. Using the Beijing region as a study area, the authors have developed a spatially explicit ecosystem services value index and implemented this to quantify and spatially differentiate ecosystem services value at 1-km grid resolution. A gravity model was developed to trace spatial change in the total ecosystem services value of the Beijing study area from a holistic point of view.

[Concept and methodology on up-scaling issue of small watershed prototypes for reconstructing ecological economies in Loess Plateau].

The general ecological situation of Loess Plateau is kept deteriorating, despite great efforts have been made and some achievements were gained after 50 years' endeavor to control soil erosion and renovate ecological landscape. Investigations on the past 20 years results from 11 experimental sites showed that the extension of prototypes and models derived from these sites, which were all based on one scale of small watershed, were unsatisfactory. The possible reasons for such a situation could be attributed to the too coarse scale of map, on which, the regional planning were set up and the locations of these experiment sites were decided, the too fine scale of the small watershed which were usually 3-10 km2 in size, the shortage of studies on various scales particularly on the meso-scale, and the lack of methods of scaling on up-scaling.