Lignin-based supports for metal nanoparticles (NPs) have attracted significant attention due to their abundant functional groups that facilitate NPs loading. However, many studies involve a two-step process: fabricating lignin particles and then reducing metal ions to NPs using physical energy consumption or chemical reduction. A one-step in-situ reduction method for NP synthesis on carrier surfaces, eliminating energy consumption, is needed for environmentally friendly and sustainable approach.
View Article and Find Full Text PDFHere, we investigated the complexation of short chain amylose (SCAs) and palmitic acid (PA), serving as polymeric building blocks that alter the selectivity and directionality of particle growth. This alteration affects the shape anisotropy of the particles, broadening their applications due to the increased surface area. By modifying the concentration of PA, we were able to make spherical, macaron, and disc-shaped particles, demonstrating that PA acts as a structure-directing agent.
View Article and Find Full Text PDFGlutathione (GSH) is indispensable for maintaining redox homeostasis in biological fluids and serves as a key component in cellular defense mechanisms. Accurate assessment of GSH relative to its oxidized counterpart, glutathione disulfide (GSSG), is critical for the early diagnosis and understanding of conditions related to oxidative stress. Despite existing methods for their quantification, the label-free and simultaneous measurement of GSH and GSSG in biological fluid presents significant challenges.
View Article and Find Full Text PDFA 13-year-old spayed female cocker spaniel was presented with a 2-month history of swelling in several digits and intermittent hindlimb lameness. Radiographs revealed marked soft-tissue swelling and periosteal new bone formation without cortical bone destruction, characteristic of hypertrophic osteopathy (HO), in the distal parts of all extremities except for the right forelimb. However, no notable findings were detected in thoracic radiographs.
View Article and Find Full Text PDFUncontrolled hemorrhage and infection are the principal causes of mortality associated with trauma in both military and civilian medical settings. Modified starch granules have emerged as a safe hemostatic agent for irregular and noncompressible wounds, but their performance is constrained by limited hemostasis efficiency and modest antibacterial activity. This study reported a directed self-assembly approach for a multifunctional mesoporous starch-based microparticle loaded with chitosan and calcium ions (Ca@MSMP) used for rapid hemostasis and wound healing.
View Article and Find Full Text PDFGastrointestinal stromal tumors arising from gastric cardia are uncommon in dogs. A few studies have shown the effectiveness of tyrosine kinase inhibitors in the treatment of canine gastrointestinal stromal tumors, but no standardized protocols are currently available. An 11-year-old spayed female Maltese dog was diagnosed with a gastrointestinal stromal tumor using histopathological and immunohistochemical analyses.
View Article and Find Full Text PDFα-Glucan microparticles (GMPs) have significant potential as high-value biomaterials in various industries. This study proposes a bottom-up approach for producing GMPs using four amylosucrases from sp. (BASs).
View Article and Find Full Text PDFZinc oxide (ZnO) is a zinc supplement widely used in health products and is approved by the FDA as Generally Regarded as Safe (GRAS). However, concerns have arisen regarding the potential health effects of nanoscale ZnO, as its reactivity differs from that of its bulk form. This has led to the need for an efficient method to extract ZnO from food products without altering its physicochemical properties, where conventional methods have proven to be inadequate.
View Article and Find Full Text PDFThiopeptides exhibit potent antimicrobial activity against Gram-positive pathogens by inhibiting bacterial protein synthesis. Micrococcins are among the structurally simpler thiopeptides, but they have not been exploited in detail. This research involved a computational simulation of micrococcin P2 (MP2) docking in parallel with the structure-activity relationship (SAR) studied.
View Article and Find Full Text PDFShort-chain glucan (SCG) is a linear homopolymer containing 10 to 50 glucose units linked with α(1,4) glycosidic bonds. With its abundant, low-cost, nontoxic, biodegradable/biocompatible nature, self-assembled SCG particles (SSC) have emerged as functional biomaterials, which have recently attracted tremendous attentions in various fields. SCG self-assembly occurs through the spontaneous association of molecules under equilibrium conditions into stable and structurally well-defined nanoscale or micrometer-scale aggregates, which is governed by various intermolecular non-covalent interactions, including hydrogen-bonding, electrostatic, hydrophobic, and van der Waals.
View Article and Find Full Text PDFShort-chain glucan (SCG) derived from debranched amylopectin has emerged as a promising candidate for the production of resistant starch particle (RSP) due to its controllable self-assembly features. Here, we investigated the effect of metal cations with different valencies and concentrations on the morphology, physicochemical properties, and digestibility of RSP formed by the self-assembly of SCG. The effect of cations on the formation of RSP followed the valency in the following order: Na, Ka, Mg, Ca, Fe, and Al, of which 10 mM trivalent cations increased the particle size of RSP over 2 μm and considerably decreased the crystallinity by 49.
View Article and Find Full Text PDFWhile recent research has shown that holographic displays can represent photorealistic 3D holograms in real time, the difficulty in acquiring high-quality real-world holograms has limited the realization of holographic streaming systems. Incoherent holographic cameras, which record holograms under daylight conditions, are suitable candidates for real-world acquisition, as they prevent the safety issues associated with the use of lasers; however, these cameras are hindered by severe noise due to the optical imperfections of such systems. In this work, we develop a deep learning-based incoherent holographic camera system that can deliver visually enhanced holograms in real time.
View Article and Find Full Text PDFA fine, hygroscopic, and poorly flowable probiotic powder encapsulating GG (LGG) was granulated using a high-shear granulation process, wherein a small amount of water (4%, ) was used for moisture-activation with or without 10% () resistant maltodextrin (RM). The process consisted of four steps; premixing, agglomeration, moisture absorption, and drying steps. The moisture content, water activity, and viable cell count were monitored during the granulation.
View Article and Find Full Text PDFThe effect of eight different l-amino acids (L-AA) on type-3 resistant starch particles (rSPs) derived from short chain glucan (SCG) was investigated. The L-AA were categorized based on their charge and polarity. The results reveal that positively charged L-AA, such as lysine and arginine, decreased the nucleation and growth rate of rSPs, while non-charged L-AA have negligible effects.
View Article and Find Full Text PDFResistant starch particles (RSP) formed by antisolvent precipitation method has attracted much attention as a functional food ingredient having beneficial effects on obesity and diabetes. However, the effect of solvent polarity on the physicochemical properties and digestibility of RSP remains unclear. Here, n-propanol, isopropanol, acetone, and ethanol were employed as antisolvents to prepare RSP.
View Article and Find Full Text PDFCarbohydr Polym
October 2022
Resistant starch (RS) has emerged as a promising functional food ingredient. To improve the textural and sensory characteristics of RS, there need to be an effective approach to produce RS with well-defined size and shape. Here, we present a facile approach for the synthesis of highly uniform resistant starch nanoparticles (RSNP) based on recrystallization of short-chain glucan (SCG) originated from debranched starch.
View Article and Find Full Text PDFinfection is a global public health threat. Extensive assays using clinical isolates have identified micrococcin P2 (MP2, ) as a particularly effective anti- agent. MP2 possesses a mode of action that differs from other antibiotics and pharmacokinetic properties that render it especially promising.
View Article and Find Full Text PDFAs a drug carrier, starch-based microparticle (SMP) has attracted widespread attention. However, because SMP is commonly formed in aqueous media, it is facing the challenge of encapsulation of hydrophobic bioactive. Here, we present an effective method for encapsulating fucoxanthin (Fx), a model hydrophobic bioactive, within SMP formed by self-assembly of short-chain glucans (SCG), using zein nanoparticles as intermediate vectors.
View Article and Find Full Text PDFPharmaceuticals (Basel)
May 2022
The US Centers for Disease Control and Prevention (CDC) lists as an urgent bacterial threat. Yet, only two drugs, vancomycin and fidaxomicin, are approved by the FDA for the treatment of infections as of this writing, while the global pipeline of new drugs is sparse at best. Thus, there is a clear and urgent need for new antibiotics against that organism.
View Article and Find Full Text PDFWe propose a holographic stereogram synthesis method which uses holograms that are optically captured by self-interference incoherent digital holography (SIDH) based on a geometric phase lens. SIDH is a promising solution for hologram acquisition under low-coherence lighting condition. A mechanical scanning system is constructed to acquire multiple perspective holograms.
View Article and Find Full Text PDFTiO (E171) is widely used in processed food as a coloring agent. However, growing concerns about the potential health effects of TiO nanoparticles (< 100 nm) have necessitated the need for monitoring the size distribution and cytotoxic properties of food additive TiO present in commercial food. In this study, we employed magnetic separation method to extract food additive TiO from 100 commercial foods.
View Article and Find Full Text PDFThree-dimensional (3D) images reconstructed by integral imaging display are captured as a complex hologram using self-interference incoherent digital holography (SIDH) and analyzed for the volumetric image characteristics. The integrated images can present 3D perception through not only binocular disparity but also volumetric property, which is represented in forming a volume picture element, called 'voxel', and an important criterion to distinguish the integral imaging from the multiview 3D display. Since SIDH can record the complex hologram under incoherent lighting conditions, the SIDH camera system has the advantage to measure the voxel formed with the incoherent light fields.
View Article and Find Full Text PDFis one of the important clinical organisms that causes various infectious diseases, including urinary tract infections, necrotizing pneumonia, and surgical wound infections. The increase in the incidence of multidrug-resistance is a major problem in public healthcare. Therefore, a novel antibacterial agent is needed to treat this pathogen.
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