Publications by authors named "Youngkyun Lee"

Article Synopsis
  • The study aimed to compare outcomes between two types of fixation methods for femoral neck fractures in patients 50 years and older: in situ fixation and fixation after closed reduction, using data from five hospitals.
  • It included 206 patients aged around 69, finding that fixation failure and reoperation rates were significantly higher in the fixation after closed reduction group (26.7% and 20% respectively) compared to the in situ group (6.8% and 7.5%).
  • While osteonecrosis of the femoral head (ONFH) rates were similar in both groups, patients in the in situ fixation group showed better functional scores in Koval's grading at 6 and 12 months compared to the other group
View Article and Find Full Text PDF
Article Synopsis
  • The study focused on translating the International Hip Outcome Tool 12 (iHOT12) into Korean (iHOT12-K) to evaluate its effectiveness for assessing hip arthroscopy outcomes in a Korean population.
  • A cohort of 67 patients with femoroacetabular impingement participated in the research, where the iHOT12-K was tested for feasibility, internal consistency, and validity using established questionnaires.
  • Results showed that iHOT12-K has excellent internal consistency (Cronbach's alpha of 0.896) and strong convergent validity with other hip-specific questionnaires, confirming its reliability for clinical use in Korea.
View Article and Find Full Text PDF

Background: Oral squamous cell carcinoma (OSCC) is an aggressive cancer with limited treatment options. Parishin A, a natural compound derived from , possesses multiple therapeutic properties. However, its effects on OSCC remain unexplored.

View Article and Find Full Text PDF
Article Synopsis
  • * Out of the reviewed surgeries, there were only 33 revisions (0.36%) due to CoC bearing fractures, primarily involving the third-generation components, with most fractures occurring in 28 mm ceramic heads.
  • * The research indicates a low overall risk of CoC bearing fractures, with younger age and being male associated with a higher likelihood of fractures, and highlights the advancements in fourth-generation ceramics in reducing head fracture occurrences.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to assess how often screwdriver stripping occurred in the screws used during the removal of femoral neck fracture implants and to identify related risk factors.
  • The research involved analyzing data from 47 patients who had undergone surgical fixation for specific types of femoral neck fractures between November 2019 and February 2023.
  • Results showed that 27.7% of patients experienced stripping, with a higher body mass index (BMI) showing a borderline significant link to this issue, while other factors were not significantly associated.
View Article and Find Full Text PDF
Article Synopsis
  • The study examines the reliability of the revised AO/OTA classification system for diaphyseal fractures, specifically focusing on femoral shaft fractures.
  • Researchers analyzed data from 139 patients to compare the new classification with the older version using a statistical measure called Fleiss kappa.
  • Both classification systems demonstrated moderate reliability, suggesting that while standardization is important for clinical decisions, there's still a need for ongoing education and improvement in fracture classification.
View Article and Find Full Text PDF
Article Synopsis
  • Thrombocytopenia, characterized by low platelet counts, increases bleeding risks and can affect outcomes in hip arthroplasty; this study evaluated its impact on surgery results in 437 patients over 20 years.
  • The analysis categorized patients into severe (< 50 × 10/µL) and non-severe (50-149 × 10/µL) thrombocytopenia, comparing factors like blood loss, transfusion needs, and complications during hip surgery.
  • Findings showed similar surgery times and hospital stays for both groups, but those with severe thrombocytopenia required more blood transfusions, confirming that hip arthroplasties remain safe despite low platelet counts.
View Article and Find Full Text PDF
Article Synopsis
  • Cementless fixation for hip arthroplasty is gaining popularity due to benefits like shorter surgery time and avoiding complications from bone cement, but it has a risk of intraoperative periprosthetic femoral fractures (IOPFx).
  • A study reviewed 4,806 hip arthroplasties from 2003 to 2020 to identify factors increasing IOPFx risk, considering patient demographics, surgical details, and implant characteristics.
  • The study found that factors like female gender, childhood hip disease, stove-pipe femur, combined surgical approach, and the use of standard-length stems significantly increased the likelihood of IOPFx, emphasizing caution when selecting standard-length cementless stems.
View Article and Find Full Text PDF

Background: Bacterial-induced inflammation instigates the destruction of hard and soft tissues surrounding teeth in periodontitis. In severe cases, the increased number and activity of osteoclasts induces the resorption of alveolar bones, ultimately leading to tooth loss. Because of their diverse chemical structures and bioactivities, natural compounds are often suggested to treat a wide variety of diseases, including inflammatory disorders.

View Article and Find Full Text PDF
Article Synopsis
  • * Most patients (84%) were treated nonoperatively, however, those who underwent surgery (16%) had a higher chance of needing total hip arthroplasty (THA) later on.
  • * The findings suggest that the type of initial treatment institution plays a role, with general hospitals showing a higher rate of subsequent THA compared to tertiary hospitals.
View Article and Find Full Text PDF

Background: Linkage errors that occur according to linkage levels can adversely affect the accuracy and reliability of analysis results. This study aimed to identify the differences in results according to personally identifiable information linkage level, sample size, and analysis methods through empirical analysis.

Methods: The difference between the results of linkage in directly identifiable information (DII) and indirectly identifiable information (III) linkage levels was set as III linkage based on name, date of birth, and sex and DII linkage based on resident registration number.

View Article and Find Full Text PDF
Article Synopsis
  • Periprosthetic tissue inflammation, often caused by wear debris from polyethylene in joint replacements, poses significant complications in surgeries.
  • This study explored the impact of grafting a MEDSAH polymer onto polyethylene surfaces, finding that it reduced pro-inflammatory cytokine expression in mouse osteoblasts but did not affect macrophage inflammation.
  • The results indicate that MEDSAH coatings could help reduce inflammation and prevent complications in joint replacements, but further clinical research and biomechanical studies are necessary to confirm their long-term effectiveness.
View Article and Find Full Text PDF
Article Synopsis
  • Hemiarthroplasty is a common treatment for displaced femoral neck fractures in elderly patients, but it carries a risk of dislocation; a new method called the posterior approach with inferior capsulotomy (PAICO) was introduced to improve stability.
  • A study compared 25 patients treated with PAICO to a historical control group of 3,477 patients who had a conventional approach and found no dislocations in the PAICO group versus a 1.3% rate in the control group.
  • The PAICO technique showed similar operation times and complication rates, and it is recommended for surgeons seeking to minimize dislocation risks in knee surgeries.
View Article and Find Full Text PDF
Article Synopsis
  • Basicervical femoral neck fractures (FNFs) are rare but unstable, leading to a higher chance of fixation failure after surgery.
  • This study analyzed 77 patients with basicervical FNFs to compare two treatment methods: multiple cannulated screws (MCS) and fixed angle devices (FAD).
  • Results showed a significantly higher reoperation rate for MCS (23.5%) compared to FAD (2.8%), suggesting that FAD might be the better option for treating these fractures.
View Article and Find Full Text PDF

Prohibitin (PHB) is an essential scaffold protein that modulates signaling pathways controlling cell survival, metabolism, inflammation, and bone formation. However, its specific role in periodontium development remains less understood. This study aims to elucidate the expression pattern and function of PHB in periodontium development and its involvement in alveolar bone formation.

View Article and Find Full Text PDF

Objective And Background: This research aimed to examine the role of C-X-C motif chemokine ligand 5 (CXCL5) and C-X-C motif chemokine ligand 8 (CXCL8; also known as IL-8) in neutrophilic inflammation triggered by peri-implantitis and to shed light on the underlying mechanisms that link them to the development of this condition.

Materials: This study included 40 patients who visited the Department of Periodontology at Kyungpook University Dental Hospital. They were divided into two groups based on their condition: healthy implant (HI) group (n = 20) and peri-implantitis (PI) group (n = 20).

View Article and Find Full Text PDF
Article Synopsis
  • * The research found that MerTK expression decreases when osteoblast precursors are stimulated by BMP2, and MerTK-deficient mice showed increased bone volume due to higher bone formation and lower resorption, linked to enhanced signaling pathways in osteoblasts.
  • * The findings suggest that targeting MerTK could be a potential treatment for bone-lytic diseases like periodontitis and osteoporosis, since MerTK deficiency was associated with a reduction in osteoclast differentiation and bone
View Article and Find Full Text PDF
Article Synopsis
  • - The study aimed to evaluate how orthopedic surgeons in South Korea treat osteoporosis in patients who have had hip fractures, based on responses from 97 members of the Korean Hip Society.
  • - Results showed that the majority of surgeons were experienced and commonly performed vitamin D testing; most often prescribing calcium, vitamin D, and denosumab as first-line treatments.
  • - The findings emphasized the importance of orthopedic surgeons' involvement in osteoporosis management, indicating that most participants aligned with current treatment strategies to reduce fracture risk.
View Article and Find Full Text PDF
Article Synopsis
  • - The study aimed to assess the accuracy of a method for positioning hip replacement cups and to measure the dislocation rate after total hip arthroplasty (THA).
  • - The researchers positioned patients laterally, took X-rays to measure pelvic pitch, and calculated the ideal cup positioning using adjustments for pitch and anteversion; they evaluated 478 THA procedures.
  • - Results showed the cup positioning was mostly accurate, with 82.4% falling within the "safe zone," and no dislocations occurred during the follow-up period of 2 to 5 years, suggesting the method's reliability.
View Article and Find Full Text PDF
Article Synopsis
  • A study aimed to create a deep learning model to predict the risk of subsequent fractures in patients who recently experienced a hip fracture, by using digitally reconstructed radiographs from hip CT scans.
  • The research analyzed data from 1,012 patients for model development and validated it on another 468 patients, finding that the ensemble model significantly outperformed other existing prediction models in terms of accuracy over 2, 3, and 5 years.
  • Results indicated that the new model had higher probabilities of predicting fractures compared to both image-based models and a clinical model that considered established risk factors, showcasing its potential for improving patient care.
View Article and Find Full Text PDF

The oral colonization of periodontal pathogens onto gingival tissues establishes hypoxic microenvironment, often disrupting periodontal homeostasis in conjunction with oxidative stress. The association between reactive oxygen species (ROS) and osteolytic periodontitis have been suggested by recent studies. PTEN-induced kinase 1 (PINK1), a mitochondrial serine/threonine kinase, is an essential protein for mitochondrial quality control as it protects cells from oxidative stress by promoting degradation of damaged mitochondria through mitophagy.

View Article and Find Full Text PDF

Lipid biosynthesis is recently studied its functions in a range of cellular physiology including differentiation and regeneration. However, it still remains to be elucidated in its precise function. To reveal this, we evaluated the roles of lysophosphatidic acid (LPA) signaling in alveolar bone formation using the LPA type 2 receptor (LPAR2) antagonist AMG-35 (Amgen Compound 35) using tooth loss without periodontal disease model which would be caused by trauma and usually requires a dental implant to restore masticatory function.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigated bone turnover markers (BTMs) - CTX, P1NP, and osteocalcin - in Korean patients with osteoporosis through a multicenter clinical analysis.
  • It focused on pre- and post-menopausal women and men, collecting demographic data and measuring BTM levels, while excluding patients without sufficient test results.
  • Results showed significant BTM levels in both genders, with teriparatide increasing P1NP and denosumab decreasing CTX, providing valuable data for future bone health assessments in Koreans.
View Article and Find Full Text PDF

Classifying patients with osteoporosis according to fracture risk and establishing adequate treatment strategies is crucial to effectively treat osteoporosis. The Korean Society for Bone and Mineral Research has issued a position statement regarding appropriate treatment strategies for postmenopausal osteoporosis. According to previous fragility fracture history, bone mineral density (BMD) test results, fracture risk assessment tool, and several clinical risk factors, fracture risk groups are classified into low, moderate, high, and very-high-risk groups.

View Article and Find Full Text PDF