Synthesis and micellar characteristics of dendron-PEG conjugates.

Urethane-amide dendrons of up to the third generation were synthesized via a convergent route. These dendrons were coupled with MeO-PEG (Mn = 2000), and the micellar characteristics of dendron-PEG conjugates in water were investigated. The conjugates with the second or third generation dendron (PEG-2GOc and PEG-30c) formed micellar aggregates in an aqueous phase.

Synthesis and self-association behavior of biodegradable amphiphilic poly[bis(ethyl glycinat-N-yl)phosphazene]- poly(ethylene oxide) block copolymers.

Amphiphilic diblock copolymers with varying compositions of hydrophilic poly(ethylene oxide) (PEO) and hydrophobic poly[bis(ethyl glycinat-N-yl)phosphazene] (PNgly) were synthesized via the controlled cationic-induced polymerization of a phosphoranimine (Cl(3)P=NSiMe(3)) at ambient temperature using a PEO-phosphoranimine macroinitiator. The aqueous-phase transition behavior of PEO-PNgly-3 (M(n) = 10,000) and micelle formation of both PEO-PNgly-3 and PEO-PNgly-4 (M(n) = 8,500) were investigated using fluorescence techniques and dynamic light scattering. The critical micelle concentrations (cmc's) of PEO-PNgly-3 and PEO-PNgly-4 were determined to be 3 and 12 mg/L with the mean diameters of micelles being 120 and 130 nm, respectively.